接受瓣膜置换术的重度主动脉瓣狭窄患者的转甲状腺素淀粉样变性心肌病:一项多中心研究。

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI:10.1080/14796678.2024.2393031
Tamara Pereira, Raquel Menezes Fernandes, Emídio Mata, Olga Azevedo, Dina Bento, Ilídio Jesus, António Lourenço
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引用次数: 0

摘要

目的:评估TTR淀粉样心肌病(ATTR-CM)在重度主动脉瓣狭窄(SAS)患者中的患病率,并确定主要不良事件(MAE)的独立预测因素。患者和方法:91名年龄大于65岁、室间隔厚度≥12.5 mm的SAS患者被转诊接受主动脉瓣置换术(AVR)。在没有单克隆蛋白的情况下,应用 99mTc-DPD 闪烁扫描诊断 ATTR-CM:结果:11%的患者发现了 ATTR-CM。78%的患者接受了 AVR,但只有 2 人患有 ATTR-CM。所有死因和心血管住院治疗的综合结果无明显差异。左心室射血分数较低和未进行 AVR 是 MAE 的独立预测因素:结论:无论ATTR-CM诊断与否,未进行AVR都是MAE的独立预测因素。
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Transthyretin amyloid cardiomyopathy in severe aortic stenosis submitted to valve replacement: a multicenter study.

Aim: To evaluate the prevalence of TTR amyloid cardiomyopathy (ATTR-CM) in severe aortic stenosis (SAS) patients, and to determine the independent predictors of major adverse events (MAE).Patients & methods: 91 SAS patients >65 years with an interventricular septum thickness ≥12.5 mm were referred for aortic valve replacement (AVR). 99mTc-DPD scintigraphy was applied to diagnose ATTR-CM, in the absence of monoclonal protein.Results: ATTR-CM was found in 11%. 78% of patients underwent AVR, but only 2 had ATTR-CM. There were no significant differences in the composite of all cause-mortality or cardiovascular hospitalizations. Lower left ventricle ejection fraction and not performing AVR were independent predictors of MAE.Conclusion: Not performing AVR was an independent predictor of MAE, regardless the ATTR-CM diagnosis.

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来源期刊
Future cardiology
Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.80
自引率
5.90%
发文量
87
期刊介绍: Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.
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