优势循环:植物中 microRNA 与其目标转录因子之间的基因调控回路。

IF 6.5 1区 生物学 Q1 PLANT SCIENCES Plant Physiology Pub Date : 2024-09-04 DOI:10.1093/plphys/kiae462
Naveen Shankar, Utpal Nath
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引用次数: 0

摘要

20-24 个核苷酸的微小核糖核酸(miRNA)及其目标转录因子(TF)已成为植物多种过程(包括器官发育和环境适应能力)的关键调控因子。在一些情况下,成熟的 miRNA 会降解 TF 编码的转录本,而它们的蛋白产物反过来又会与相应的 miRNA 编码基因的启动子结合并调节其表达,从而形成反馈回路(FBL)或前馈回路(FFL)。计算分析表明,这种 miRNA-TF 循环是植物和动物基因调控网络(GRN)中经常出现的模式。近年来,建模和实验研究表明,植物基因调控网络中的 miRNA-TF 环路在驱动器官发育和非生物胁迫响应方面发挥着关键作用。在此,我们讨论了过去十年中在植物中发现和研究的 miRNA-TF FBLs 和 FFLs。然后,我们将深入探讨这些基序在 GRN 中可能发挥的作用。最后,我们展望了剖析植物中以 miRNA 为中心的 GRN 功能的未来方向。
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Advantage looping: Gene regulatory circuits between microRNAs and their target transcription factors in plants.

The 20-24 nucleotide microRNAs (miRNAs) and their target transcription factors (TF) have emerged as key regulators of diverse processes in plants, including organ development and environmental resilience. In several instances, the mature miRNAs degrade the TF-encoding transcripts, while their protein products in turn bind to the promoters of the respective miRNA-encoding genes and regulate their expression, thus forming feedback loops (FBLs) or feedforward loops (FFLs). Computational analysis suggested that such miRNA-TF loops are recurrent motifs in gene regulatory networks (GRNs) in plants as well as animals. In recent years, modeling and experimental studies have suggested that plant miRNA-TF loops in GRNs play critical roles in driving organ development and abiotic stress responses. Here, we discuss the miRNA-TF FBLs and FFLs that have been identified and studied in plants over the past decade. We then provide some insights into the possible roles of such motifs within GRNs. Lastly, we provide perspectives on future directions for dissecting the functions of miRNA-centric GRNs in plants.

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来源期刊
Plant Physiology
Plant Physiology 生物-植物科学
CiteScore
12.20
自引率
5.40%
发文量
535
审稿时长
2.3 months
期刊介绍: Plant Physiology® is a distinguished and highly respected journal with a rich history dating back to its establishment in 1926. It stands as a leading international publication in the field of plant biology, covering a comprehensive range of topics from the molecular and structural aspects of plant life to systems biology and ecophysiology. Recognized as the most highly cited journal in plant sciences, Plant Physiology® is a testament to its commitment to excellence and the dissemination of groundbreaking research. As the official publication of the American Society of Plant Biologists, Plant Physiology® upholds rigorous peer-review standards, ensuring that the scientific community receives the highest quality research. The journal releases 12 issues annually, providing a steady stream of new findings and insights to its readership.
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