硒嘧啶杂环化学的最新进展:合成、反应性和生物活性

IF 2.1 3区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Journal of Organometallic Chemistry Pub Date : 2024-08-30 DOI:10.1016/j.jorganchem.2024.123343
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引用次数: 0

摘要

毫无疑问,嘧啶和硒吩是非常宝贵的杂环化合物,在新型药物开发中具有举足轻重的地位。将硒吩和嘧啶基团融合成杂环结构,开创了前景广阔的药理潜力领域。这种融合产生了硒吩嘧啶衍生物,如硒吩并[2,3-d]嘧啶、硒吩并[3,4-d]嘧啶和硒吩并[3,2-d]嘧啶,每种衍生物都具有引人入胜的特性。硒吩嘧啶的合成涉及多种化学途径,包括一锅多组分反应、Vilsmeier-Haack 反应、Gewald 反应和铃木交叉偶联法。
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Recent advances in the chemistry of selenophenopyrimidine heterocycles: Synthesis, reactivity, and biological activity

Undoubtedly, pyrimidine and selenophene stand as invaluable heterocyclic compounds pivotal in the quest for novel drug development. The fusion of selenophene and pyrimidine motifs into hybrid architectures has ushered in a realm of promising pharmacological potentialities. This amalgamation has given rise to selenophenopyrimidine derivatives, such as selenopheno[2,3-d]pyrimidine, selenopheno[3,4-d]pyrimidine, and selenopheno[3,2-d]pyrimidine, each boasting intriguing properties. Synthesizing selenophenopyrimidines encompasses diverse chemical pathways, including one-pot multi-component reactions, Vilsmeier-Haack reactions, Gewald reactions, and Suzuki cross-coupling methodologies.

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来源期刊
Journal of Organometallic Chemistry
Journal of Organometallic Chemistry 化学-无机化学与核化学
CiteScore
4.40
自引率
8.70%
发文量
221
审稿时长
36 days
期刊介绍: The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.
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