食用蜂胶对成人肝脏酶和肥胖指数的影响:系统回顾与剂量反应荟萃分析

IF 3.8 Q2 NUTRITION & DIETETICS Current Developments in Nutrition Pub Date : 2024-09-01 DOI:10.1016/j.cdnut.2024.104438
Mohsen Aliakbarian , Mostafa Shahraki Jazinaki , Hossein Bahari , Mohammad Rashidmayvan , Haniyeh Golafrouz , Rozita Khodashahi , Naseh Pahlavani
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引用次数: 0

摘要

背景蜂胶是一种由蜜蜂生产的天然树脂,其对肝酶和肥胖指数的潜在影响已被研究过。然而,为了全面了解蜂胶对肥胖和肝功能的影响,有必要进行一项荟萃分析。方法在PubMed/Medline、Scopus和Web of Science上完成了一项截至2023年12月的系统文献检索,以确定符合条件的RCTs。使用 I2 统计量对所选试验进行异质性检验。结果 24项试验的汇总分析表明,服用蜂胶可显著降低丙氨酸氨基转移酶(ALT)(WMD:-2.58;95% CI:-4.64,-0.52;P = 0.01)、天门冬氨酸氨基转移酶(AST)(WMD:-1.84;95% CI:-3.01,-0.67;P = 0.002)和碱性磷酸酶(ALP)(WMD:-24.90;95% CI:-42.13,-7.67;P = 0.005)。然而,与对照组相比,蜂胶对γ-谷氨酰转移酶(GGT)、体重、体重指数(以千克/平方米为单位)、脂肪量、体脂百分比、无脂肪量、脂联素、腰围、臀围和腰臀比(以千克/平方米为单位)均无明显影响。然而,未来有必要进行设计良好的研究性试验,以大量参与者和较长的持续时间为基础,重点关注蜂胶的精确剂量和成分。
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Effects of Propolis Consumption on Liver Enzymes and Obesity Indices in Adults: A Systematic Review and Dose-Response Meta-Analysis

Background

Propolis, a natural resin produced by bees, has been studied for its potential effects on liver enzymes and obesity indices. However, a meta-analysis is necessary to comprehensively understand the impact of propolis on obesity and liver function.

Objectives

This meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of propolis consumption on liver enzymes and obesity indices in adults.

Methods

A systematic literature search up to December 2023 was completed in PubMed/Medline, Scopus, and Web of Science, to identify eligible RCTs. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random-effects models were assessed on the basis of the heterogeneity tests, and pooled data were determined as weighted mean differences (WMDs) with a 95% confidence interval (CI).

Results

A pooled analysis of 24 trials showed that propolis consumption led to a significant reduction in alanine aminotransferase (ALT) (WMD: −2.58; 95% CI: −4.64, −0.52; P = 0.01), aspartate aminotransferase (AST) (WMD: −1.84; 95% CI: −3.01, −0.67; P = 0.002), and alkaline phosphatase (ALP) (WMD: −24.90; 95% CI: −42.13, −7.67; P = 0.005) in comparison with the control group. However, there were no significant effects on gamma-glutamyl transferase (GGT), body weight, BMI (in kg/m2), fat mass, body fat percentage, fat-free mass, adiponectin, waist circumference, hip circumference, and waist–hip ratio in comparison with the control group.

Conclusions

We discovered that consuming propolis can lead to a significant decrease in ALT, AST, and ALP levels, without causing significant changes in GGT, anthropometric indices, and adiponectin levels. However, future well-designed RCTs with large numbers of participants and extended durations, focusing on precise propolis dosage and ingredients, are necessary.

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来源期刊
Current Developments in Nutrition
Current Developments in Nutrition NUTRITION & DIETETICS-
CiteScore
5.30
自引率
4.20%
发文量
1327
审稿时长
8 weeks
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