{"title":"用于脑成像的 BLUsH","authors":"","doi":"10.1016/j.matt.2024.07.008","DOIUrl":null,"url":null,"abstract":"<div><p>Bioluminescent reporters are widely used in fundamental and preclinical biological research. However, light absorption and scattering by tissues interferes with precise mapping of bioluminescent sources in deep locations, such as the brain, where the skull significantly blocks optical signal transmission. This preview highlights an ingenious approach that employs a cellular near-field camera to convert optical signals into hemodynamic changes detectable by magnetic resonance imaging. This transformation overcomes the optical limitations of tissue penetration depth and enables more precise mapping of bioluminescence sources in the brain.</p></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":null,"pages":null},"PeriodicalIF":17.3000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"BLUsH for brain imaging\",\"authors\":\"\",\"doi\":\"10.1016/j.matt.2024.07.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bioluminescent reporters are widely used in fundamental and preclinical biological research. However, light absorption and scattering by tissues interferes with precise mapping of bioluminescent sources in deep locations, such as the brain, where the skull significantly blocks optical signal transmission. This preview highlights an ingenious approach that employs a cellular near-field camera to convert optical signals into hemodynamic changes detectable by magnetic resonance imaging. This transformation overcomes the optical limitations of tissue penetration depth and enables more precise mapping of bioluminescence sources in the brain.</p></div>\",\"PeriodicalId\":388,\"journal\":{\"name\":\"Matter\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.3000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Matter\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590238524004016\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Matter","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590238524004016","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Bioluminescent reporters are widely used in fundamental and preclinical biological research. However, light absorption and scattering by tissues interferes with precise mapping of bioluminescent sources in deep locations, such as the brain, where the skull significantly blocks optical signal transmission. This preview highlights an ingenious approach that employs a cellular near-field camera to convert optical signals into hemodynamic changes detectable by magnetic resonance imaging. This transformation overcomes the optical limitations of tissue penetration depth and enables more precise mapping of bioluminescence sources in the brain.
期刊介绍：
Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content.
Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.
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