用于脑成像的 BLUsH

IF 17.5 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Matter Pub Date : 2024-09-04 DOI:10.1016/j.matt.2024.07.008

Yuxia Liu , Mingyu Sui , Xiaogang Liu

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引用次数: 0

摘要

生物发光报告广泛应用于基础和临床前生物研究。然而，组织对光的吸收和散射会干扰生物发光源在大脑等深部位置的精确绘图，因为头骨会严重阻碍光信号的传输。本预览重点介绍一种巧妙的方法，它利用细胞近场相机将光信号转换为磁共振成像可检测到的血液动力学变化。这种转换克服了组织穿透深度的光学限制，能够更精确地绘制大脑中的生物发光源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BLUsH for brain imaging

Bioluminescent reporters are widely used in fundamental and preclinical biological research. However, light absorption and scattering by tissues interferes with precise mapping of bioluminescent sources in deep locations, such as the brain, where the skull significantly blocks optical signal transmission. This preview highlights an ingenious approach that employs a cellular near-field camera to convert optical signals into hemodynamic changes detectable by magnetic resonance imaging. This transformation overcomes the optical limitations of tissue penetration depth and enables more precise mapping of bioluminescence sources in the brain.

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来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.