与抗精神病药相关的乳腺癌

Y. W. Francis Lam Pharm.D., FCCP
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摘要

研究数据表明,抗精神病药物诱发的高泌乳素血症与较高的乳腺癌风险之间存在关联(Rahman 等人,2022 年;另见 "使用抗精神病药物的乳腺癌风险与泌乳素水平有关;"https://doi.org/10.1002/pu.30853)。这可能是由于抗精神病药物(尤其是第一代药物)具有抗多巴胺能的特性。
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Antipsychotic-associated breast cancer

Research data suggest an association between antipsychotic-induced hyperprolactinemia and higher risk of breast cancer (Rahman et al., 2022; also, see “Breast cancer risk with antipsychotic use linked to prolactin levels;” https://doi.org/10.1002/pu.30853). This is likely secondary to the anti-dopaminergic properties of antipsychotics, especially those of first-generation agents.

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