改性壳聚糖的合成与表征--一种有前途的重金属离子肠道吸附材料

IF 2.4 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Carbohydrate Research Pub Date : 2024-08-31 DOI:10.1016/j.carres.2024.109255
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引用次数: 0

摘要

目前,一个重要的生态问题是环境污染及其对生物体的负面影响,其后果是整体健康恶化和各种疾病、中毒、内毒素中毒和外毒素中毒的表现。肠道吸附法是利用肠道吸附剂去除生物体内有毒物质的一种可行方法,肠道吸附剂可在胃肠道腔内吸附各种内源性和外源性有毒物质。有人建议使用含聚合物的肠吸附剂来清除生物体内的重金属。本研究的目的是合成壳聚糖的季铵化衍生物,特别是 N-(2-羟基苄基)-N-乙基-N-甲基壳聚糖氯化物(Q-CHS)。Q-CHS 的合成过程包括形成希夫碱,然后对壳聚糖(CHS)的氨基进行季铵化。为了确定纯 CHS 和季铵化 CHS 的结构并确认最终产品的形成,研究人员采用了各种物理化学方法,包括傅立叶变换红外光谱、核磁共振、XRD、扫描电镜、DSC 和热重分析。
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Synthesis and characterization of modified chitosan as a promising material for enterosorption of heavy metal ions

Currently, an important ecological problem is environmental pollution and its negative impact on living organisms, the consequences of which are deterioration in general health and the manifestation of various diseases, poisoning, endo- and exotoxicosis. Enterosorption method was proposed as a promising method for removing toxic substances from the living organisms using enterosorbents which can absorb various toxic substances of endogenous and exogenous nature in the lumen of the gastrointestinal tract. It has been proposed to use polymer-containing enterosorbents for eliminating of heavy metals from the organism. The purpose of this research was to synthesize a quaternized derivative of chitosan, specifically N-(2-hydroxybenzyl)-N-ethyl-N-methyl chitosan chloride (Q-CHS). The synthesis of Q-CHS involved the formation of a Schiff base, followed by the quaternization of the amino group of chitosan (CHS). The structures of both pure CHS and quaternized CHS were studied using various physico-chemical methods, including FTIR, NMR, XRD, SEM, DSC and TGA analyses in order to determine the structure and confirm the formation of the final product.

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来源期刊
Carbohydrate Research
Carbohydrate Research 化学-生化与分子生物学
CiteScore
5.00
自引率
3.20%
发文量
183
审稿时长
3.6 weeks
期刊介绍: Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".
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