老年人偏头痛与大脑结构:鹿特丹研究

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Cephalalgia Pub Date : 2024-09-01 DOI:10.1177/03331024241266951
Cevdet Acarsoy, Mohammad Kamran Ikram, Mohammad Arfan Ikram, Meike W Vernooij, Daniel Bos
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引用次数: 0

摘要

背景:最近的研究表明,偏头痛患者发生脑结构变化(包括脑小血管疾病和脑萎缩)的风险可能较高。然而,文献中的研究结果并不一致,在所报道的影响方向、程度和人群特征方面都存在差异,而且大规模的人群证据仍然很少。因此,我们在中老年人群中调查了偏头痛与脑结构变化的关系:方法:在以人群为基础的鹿特丹研究中,使用经过验证的问卷对2006年至2011年间的偏头痛终生病史进行了评估。对 4920 名参与者(中位年龄 61.7 [IQR 45.5, 97.5] 岁,55.4% 为女性)进行了脑部磁共振成像,以评估脑小血管疾病和脑萎缩的成像标记物。我们使用线性回归和逻辑回归模型来检验偏头痛与脑容量(灰质和白质总容量,以毫升为单位)和脑小血管疾病标志物(白质高密度容量,以毫升为单位,有无裂隙和脑微出血)之间的横断面关联。对年龄、性别、颅内容积和心血管变量进行了调整。还根据性别和是否有先兆进行了分层分析:结果:偏头痛的终生患病率为15.3%(752/4920)。在多变量调整回归模型中,我们发现偏头痛患者与非偏头痛患者在脑总量(平均差异 [MD]:2.21 mL,95% 置信区间 [CI]:-0.38 ; 4.81)、灰质体积(MD:0.38 mL,95% 置信区间 [CI]:-1.98;2.74)、白质体积(MD:2.19 mL,95% CI:-0.56;4.93)、对数白质高密度体积(MD:-0.04 mL,95% CI:-0.10;0.02)、有无裂隙(几率比 [OR]:0.82,95% CI:0.58-1.15)和有无脑微小出血(OR:0.95,95% CI:0.76-1.18):在这项研究中,我们发现中老年偏头痛患者在磁共振成像中出现脑结构变化的可能性并不大。
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Migraine and brain structure in the elderly: The Rotterdam Study.

Background: Recent studies suggested that persons with migraine might be at higher risk of structural brain changes, including cerebral small vessel disease and atrophy. However, findings in the literature are inconsistent, with variations observed in the direction, magnitude, and population characteristics of reported effects, and large-scale population-based evidence remains scarce. Hence, we investigated the association of migraine with structural brain changes in a middle-aged and elderly population.

Methods: Within the population-based Rotterdam Study, lifetime history of migraine was assessed using a validated questionnaire between 2006 and 2011. Magnetic resonance imaging of the brain was performed in 4920 participants (median age 61.7 [IQR 45.5, 97.5] years, 55.4% female) to assess imaging markers of cerebral small vessel disease and brain atrophy. We used linear and logistic regression models to examine the cross-sectional association of migraine with brain volumes (total grey and white matter volumes in mL) and cerebral small vessel disease markers (white matter hyperintensity volume in mL, presence of lacunes and cerebral microbleeds). Adjustments were made for age, sex, intracranial volume and cardiovascular variables. Analyses were also stratified by sex and presence of aura.

Results: The lifetime prevalence of migraine was 15.3% (752/4920). In multivariable adjusted regression models, we found no statistically significant differences between participants with and without migraine in terms of total brain volume (mean difference [MD]: 2.21 mL, 95% confidence interval [CI]: -0.38 ; 4.81), grey matter volume (MD: 0.38 mL, 95% CI: -1.98 ; 2.74), white matter volume (MD: 2.19 mL, 95% CI: -0.56 ; 4.93), log white matter hyperintensity volume (MD: -0.04 mL, 95% CI: -0.10 ; 0.02), presence of lacunes (odds ratio [OR]: 0.82, 95% CI: 0.58-1.15), and presence of cerebral microbleeds (OR: 0.95, 95% CI: 0.76-1.18).

Conclusion: In this study, we found that middle-aged and elderly participants with migraine were not more likely to have structural brain changes on magnetic resonance imaging.

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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
期刊最新文献
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