1 型糖尿病儿童和青少年的低碳水化合物饮食:交叉设计的随机对照试验。

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2024-09-03 DOI:10.1016/j.diabres.2024.111844
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引用次数: 0

摘要

目的:我们研究了短期严格控制低碳水化合物饮食(LCD)是否会在不增加相关风险的情况下延长儿童和青少年糖尿病患者(CYPwD)的服药时间:这项随机对照交叉研究招募了 35 名儿童和青少年糖尿病患者(20 名女性;20 名 CSII;年龄 14.5 ± 2.9 岁;HbA1c 48.9 ± 9.4 mmol/mol)。干预措施是按随机顺序分别提供五周和五周的现成盒装等热量饮食:LCD(94.5 ± 4.7 克/天)或推荐碳水化合物饮食(191 ± 19.2 克/天)。研究结果包括连续血糖监测参数、人体测量、实验室和生活质量(QoL)数据:结果:LCD 阶段在血糖范围内的时间明显高于 RCD 阶段(77.1% 对 73.8%,P=0.008)。LCD 的高血糖时间和平均血糖值明显低于 RCD。两种饮食在低血糖时间和血糖变异性方面没有差异。LCD期间,受试者的体重和体重指数明显降低。低密度脂蛋白胆固醇水平没有明显差异。在自我评估的 QoL 方面没有观察到明显差异:短期液晶显示可改善血糖参数,但不会增加低血糖时间,也不会扰乱血脂状况或对 CYPwD 的生活质量产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design

Aims

We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD).

Methods

Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female; 20 CSII; age 14.5 ± 2.9 years; HbA1c 48.9 ± 9.4 mmol/mol). The interventions were five and five weeks of ready-made food box deliveries of isocaloric diets in random order: either LCD (94.5 ± 4.7 g/day) or recommended carbohydrate diet (RCD) (191 ± 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data.

Results

Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, P=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects’ body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL.

Conclusions

Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.

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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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