Martin Purpura, Ralf Jäger, Ashok Godavarthi, Dhananjaya Bhaskarachar, Grant M Tinsley
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Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.</p><p><strong>Results: </strong>VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC<sub>0 - 24</sub> in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC<sub>0 - 24</sub> (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.</p><p><strong>Conclusion: </strong>Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.</p><p><strong>Trial registration: </strong>Clinical Trials Registry - India (CTRI/2023/04/051789).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3037-3046"},"PeriodicalIF":4.1000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519160/pdf/","citationCount":"0","resultStr":"{\"title\":\"Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial.\",\"authors\":\"Martin Purpura, Ralf Jäger, Ashok Godavarthi, Dhananjaya Bhaskarachar, Grant M Tinsley\",\"doi\":\"10.1007/s00394-024-03487-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n = 27; 36.0 ± 5.1 years, 165.0 ± 6.9 cm, 70.6 ± 7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage<sup>®</sup>, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.</p><p><strong>Results: </strong>VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC<sub>0 - 24</sub> in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC<sub>0 - 24</sub> (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.</p><p><strong>Conclusion: </strong>Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.</p><p><strong>Trial registration: </strong>Clinical Trials Registry - India (CTRI/2023/04/051789).</p>\",\"PeriodicalId\":12030,\"journal\":{\"name\":\"European Journal of Nutrition\",\"volume\":\" \",\"pages\":\"3037-3046\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519160/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00394-024-03487-8\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00394-024-03487-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
目的：左旋抗坏血酸（维生素 C）是一种必需的水溶性维生素，在包括免疫健康在内的各种生理功能中发挥着重要作用。维生素 C 在胃肠道中的稳定性限制了其生物利用度。本研究旨在探讨与标准维生素 C 相比，脂质体形式的维生素 C 能否提高吸收率：在一项随机、双盲、安慰剂对照、交叉研究中，19 名男性和 8 名女性（n = 27；36.0 ± 5.1 岁，165.0 ± 6.9 厘米，70.6 ± 7.1 千克）分别服用了单剂量的安慰剂（PLA）、500 毫克维生素 C（VIT C）和 500 毫克脂质体维生素 C（LV-VIT C，LipoVantage®，Specnova, LLC，美国弗吉尼亚州泰森角）。摄入后 0、0.5、1、1.5、2、3、4、6、8、12 和 24 小时采集静脉血样本，分析血浆和白细胞维生素 C 浓度：结果：与安慰剂相比，VIT C 和 LV-VIT C 在血浆和白细胞中的 Cmax 和 AUC0 - 24 明显更高（p 0 - 24（血浆 + 21%，白细胞 + 8%，p 结论：VIT C 和 LV-VIT C 在血浆和白细胞中的 Cmax 和 AUC0 - 24 明显更高（p 0 - 24（血浆 + 21%，白细胞 + 8%，p 0 - 24））：维生素 C 脂质体制剂可增加血浆和白细胞对维生素 C 的吸收：试验登记：印度临床试验登记处（CTRI/2023/04/051789）。
Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial.
Purpose: L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.
Methods: In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n = 27; 36.0 ± 5.1 years, 165.0 ± 6.9 cm, 70.6 ± 7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage®, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.
Results: VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC0 - 24 in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC0 - 24 (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.
Conclusion: Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.
Trial registration: Clinical Trials Registry - India (CTRI/2023/04/051789).
期刊介绍：
The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on
immunology and inflammation,
gene expression,
metabolism,
chronic diseases, or
carcinogenesis,
or a major focus on
epidemiology, including intervention studies with healthy subjects and with patients,
biofunctionality of food and food components, or
the impact of diet on the environment.
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