Paolo Rosales, Daiana Vitale, Antonella Icardi, Ina Sevic, Laura Alaniz
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引用次数: 0
摘要
在过去的几十年里,科学家们已经认识到细胞外基质(ECM)的各种成分在维持同态免疫方面发挥着至关重要的作用。此外,这些成分的合成或降解水平失调会直接影响肿瘤过程造成组织损伤时的免疫反应机制,或组织本身受损时的再生机制。ECM 是由蛋白质化合物、蛋白聚糖和糖胺聚糖 (GAG) 组成的复杂网络。透明质酸(HA)是这一网络中的主要 GAGs 之一,其新陈代谢受到严格的生理调控,并在损伤过程中迅速改变,影响从干细胞到分化免疫细胞等不同细胞的行为。在本次修订中,我们将讨论原生或化学修饰的 HA 如何与其特定受体相互作用,并调节免疫细胞的细胞内和细胞间通信,重点关注癌症和组织再生情况。
Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration.
Over the last few decades, scientists have recognized the critical role that various components of the extracellular matrix (ECM) play in maintaining homeostatic immunity. Besides, dysregulation in the synthesis or degradation levels of these components directly impacts the mechanisms of immune response during tissue injury caused by tumor processes or the regeneration of the tissue itself in the event of damage. ECM is a complex network of protein compounds, proteoglycans and glycosaminoglycans (GAGs). Hyaluronic acid (HA) is one of the major GAGs of this network, whose metabolism is strictly physiologically regulated and quickly altered in injury processes, affecting the behavior of different cells, from stem cells to differentiated immune cells. In this revision we discuss how the native or chemically modified HA interacts with its specific receptors and modulates intra and intercellular communication of immune cells, focusing on cancer and tissue regeneration conditions.
期刊介绍:
The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.