患有重性精神病的多重受影响家庭中未受影响的兄弟姐妹在教育、婚姻和职业功能方面的共同缺陷。

IF 3.8 4区 医学 Q1 PSYCHIATRY Asian journal of psychiatry Pub Date : 2024-08-30 DOI:10.1016/j.ajp.2024.104216
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引用次数: 0

摘要

背景:重大精神疾病往往在家庭中聚集,其对家庭中受影响和未受影响成员的影响可能反映了遗传和社会责任的后果:数据来自 202 个有多名患者的家庭。受影响的个体(N = 259)被诊断为精神分裂症、躁郁症、强迫症或药物使用障碍。为了进行比较,我们使用了同一家庭中未受影响的兄弟姐妹(N = 229)和来自 2016 年印度全国心理健康调查(NMHS)的健康对照(HC)数据的匹配随机子集(N = 229)。我们比较了三组人的受教育程度、功能性婚姻状况和职业状况:各组之间的最高教育程度存在明显差异。与 HC 相比,受影响和未受影响的兄弟姐妹受教育程度较低。同样,与 HC 相比,受影响和未受影响的兄弟姐妹更多地保持单身。此外,未受影响的兄弟姐妹的就业率明显较高,尤其是女性兄弟姐妹。总体而言,与男性相比,女性在三个群体中的就学年数较少,主要是已婚,而且大多数是家庭主妇:讨论:受影响和未受影响的兄弟姐妹的受教育率和结婚率均低于 HC。未受影响的兄弟姐妹比 HC 更有可能就业。未受影响的兄弟姐妹受教育程度低和结婚率低是共同内表型的生物学标志,还是受影响家庭成员的社会负担的影响,这需要进一步的系统评估。
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Shared deficits of education, marital and occupational functioning in unaffected siblings of multiple affected families with major psychiatric illness

Background

Major psychiatric illnesses often cluster in families, and their impact on affected and unaffected members within families may reflect the consequence of both genetic and social liability.

Methods

Data was derived from 202 families with multiple affected individuals. Affected individuals (N = 259) had a diagnosis of schizophrenia, bipolar disorder, obsessive-compulsive disorder or substance use disorder. For comparison, we used the unaffected siblings from the same families (N = 229) and a matched random subset of healthy control (HC) data (N = 229) from India’s National Mental Health Survey, 2016 (NMHS). We compared the three groups' educational attainment, functional marital status, and occupational status.

Results

The highest educational attainment was significantly different between the groups. The affected and unaffected siblings had poorer educational attainment compared to HC. Similarly, the affected and unaffected siblings more often remained single, in contrast to HC. Moreover, employment rates were significantly higher in the unaffected siblings, especially female siblings. Overall, females had spent fewer years at school, were primarily married, and were majority homemakers across the three groups compared to males.

Discussion

Affected and unaffected siblings had lower education and marriage rates than HC. The unaffected siblings were more likely to be employed than HC. Whether the poor educational attainment and lower marriage rates in unaffected siblings is a biological marker of shared endophenotype or the effect of the social burden of having an affected family member requires further systematic evaluation.

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来源期刊
Asian journal of psychiatry
Asian journal of psychiatry Medicine-Psychiatry and Mental Health
CiteScore
12.70
自引率
5.30%
发文量
297
审稿时长
35 days
期刊介绍: The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.
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