老年人 FTO 多态性与 COVID-19 死亡率之间的关系：一项基于人群的队列研究。

IF 4.6 2区医学 Q1 INFECTIOUS DISEASES International Journal of Infectious Diseases Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI:10.1016/j.ijid.2024.107232

Jaroslav A. Hubacek , Nadezda Capkova , Martin Bobak , Hynek Pikhart

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引用次数: 0

摘要

目的：m6A RNA去甲基化酶（FTO）及其功能性rs17817449多态性可能会影响与COVID-19相关的死亡率，因为病毒核酸的甲基化状态是影响病毒生存能力的重要因素：我们对一个由 5180 名受试者（2020 年年龄为 63-87 岁）组成的人群队列进行了测试，在大流行期间，有 70 人死于 COVID-19，341 人死于其他原因：死于 COVID-19 的人群（34%）中的 GG 同源基因频率高于幸存者（19%）或死于其他原因的人群（20%），P < 0.005。经多重调整后，与至少一个T等位基因携带者相比，GG同源基因携带者死于COVID-19的风险更高，OR = 2.01 (95% CI; 1.19 - 3.41, p < 0.01)。FTO多态性与其他原因导致的死亡率无关：我们的研究结果表明，FTO变异是白种人COVID-19相关死亡率的重要预测因素。

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Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study

Objectives

COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m⁶A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability.

Methods

We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period.

Results

The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes.

Conclusions

Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.