Isabella M Hildebrandt, Owen T Skinner, Megan A Mickelson, Todd E Daniel, Hayley L Ashworth, Annie Kim, Brandan G Wustefeld-Janssens, Tiffany W Martin, Charly McKenna, Michelle L Oblak, Valerie J Poirier, Karanbir Randhawa, Michelle M Turek, Jonathan F McAnulty, Maureen A Griffin, Lillian E Duda, Carlos R Mendez Valenzuela, Isabelle F Vanhaezebrouck, Allyson A Sterman, Christopher Bloom, Laura E Selmic, Dah-Renn Fu, Jishnu Rao Gutti, Koichi Nagata, Brian Thomsen, Arathi Vinayak, Beatrix Jenei, Charles A Maitz
{"title":"治疗犬软组织肉瘤的手术和术后确定性放射治疗:一项针对 272 只犬(2010-2020 年)的多机构回顾性研究。","authors":"Isabella M Hildebrandt, Owen T Skinner, Megan A Mickelson, Todd E Daniel, Hayley L Ashworth, Annie Kim, Brandan G Wustefeld-Janssens, Tiffany W Martin, Charly McKenna, Michelle L Oblak, Valerie J Poirier, Karanbir Randhawa, Michelle M Turek, Jonathan F McAnulty, Maureen A Griffin, Lillian E Duda, Carlos R Mendez Valenzuela, Isabelle F Vanhaezebrouck, Allyson A Sterman, Christopher Bloom, Laura E Selmic, Dah-Renn Fu, Jishnu Rao Gutti, Koichi Nagata, Brian Thomsen, Arathi Vinayak, Beatrix Jenei, Charles A Maitz","doi":"10.2460/javma.24.06.0363","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.</p><p><strong>Methods: </strong>Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted. Selected variables were assessed for association with local progression and overall survival.</p><p><strong>Results: </strong>272 dogs were included. Histologic grade was reported in 249 dogs: 102 were grade 1 (40.9%), 120 were grade 2 (48.2%), and 27 were grade 3 (10.8%). Local progression was suspected or confirmed in 56 dogs. Local progression rates were similar for grade 1 (24 of 89 [26.7%]), grade 2 (23 of 111 [20.7%]), and grade 3 tumors (6 of 22 [27.3%]). Previous recurrence (P = .010) and subsequent distant metastasis (P = .014) were associated with more frequent local progression; intensity-modulated radiotherapy was associated with decreased local progression (P = .025) compared to other forms of delivery. Age (P = .049), grade (P = .009), previous recurrence (P = .009), and institution type for surgery (P = .043) were associated with overall survival.</p><p><strong>Conclusions: </strong>Outcomes for most dogs were good; however, the frequency of local progression indicates an ongoing need to critically appraise local management strategies, particularly for low-grade STS. Intensity-modulated radiotherapy was associated with lower rates of local progression and may be preferred to less precise forms of delivery.</p><p><strong>Clinical relevance: </strong>These data may guide clinicians when making decisions regarding dRT for management of STS.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010-2020).\",\"authors\":\"Isabella M Hildebrandt, Owen T Skinner, Megan A Mickelson, Todd E Daniel, Hayley L Ashworth, Annie Kim, Brandan G Wustefeld-Janssens, Tiffany W Martin, Charly McKenna, Michelle L Oblak, Valerie J Poirier, Karanbir Randhawa, Michelle M Turek, Jonathan F McAnulty, Maureen A Griffin, Lillian E Duda, Carlos R Mendez Valenzuela, Isabelle F Vanhaezebrouck, Allyson A Sterman, Christopher Bloom, Laura E Selmic, Dah-Renn Fu, Jishnu Rao Gutti, Koichi Nagata, Brian Thomsen, Arathi Vinayak, Beatrix Jenei, Charles A Maitz\",\"doi\":\"10.2460/javma.24.06.0363\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.</p><p><strong>Methods: </strong>Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted. Selected variables were assessed for association with local progression and overall survival.</p><p><strong>Results: </strong>272 dogs were included. Histologic grade was reported in 249 dogs: 102 were grade 1 (40.9%), 120 were grade 2 (48.2%), and 27 were grade 3 (10.8%). Local progression was suspected or confirmed in 56 dogs. Local progression rates were similar for grade 1 (24 of 89 [26.7%]), grade 2 (23 of 111 [20.7%]), and grade 3 tumors (6 of 22 [27.3%]). Previous recurrence (P = .010) and subsequent distant metastasis (P = .014) were associated with more frequent local progression; intensity-modulated radiotherapy was associated with decreased local progression (P = .025) compared to other forms of delivery. Age (P = .049), grade (P = .009), previous recurrence (P = .009), and institution type for surgery (P = .043) were associated with overall survival.</p><p><strong>Conclusions: </strong>Outcomes for most dogs were good; however, the frequency of local progression indicates an ongoing need to critically appraise local management strategies, particularly for low-grade STS. Intensity-modulated radiotherapy was associated with lower rates of local progression and may be preferred to less precise forms of delivery.</p><p><strong>Clinical relevance: </strong>These data may guide clinicians when making decisions regarding dRT for management of STS.</p>\",\"PeriodicalId\":14658,\"journal\":{\"name\":\"Javma-journal of The American Veterinary Medical Association\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Javma-journal of The American Veterinary Medical Association\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.2460/javma.24.06.0363\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Javma-journal of The American Veterinary Medical Association","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/javma.24.06.0363","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010-2020).
Objective: To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.
Methods: Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted. Selected variables were assessed for association with local progression and overall survival.
Results: 272 dogs were included. Histologic grade was reported in 249 dogs: 102 were grade 1 (40.9%), 120 were grade 2 (48.2%), and 27 were grade 3 (10.8%). Local progression was suspected or confirmed in 56 dogs. Local progression rates were similar for grade 1 (24 of 89 [26.7%]), grade 2 (23 of 111 [20.7%]), and grade 3 tumors (6 of 22 [27.3%]). Previous recurrence (P = .010) and subsequent distant metastasis (P = .014) were associated with more frequent local progression; intensity-modulated radiotherapy was associated with decreased local progression (P = .025) compared to other forms of delivery. Age (P = .049), grade (P = .009), previous recurrence (P = .009), and institution type for surgery (P = .043) were associated with overall survival.
Conclusions: Outcomes for most dogs were good; however, the frequency of local progression indicates an ongoing need to critically appraise local management strategies, particularly for low-grade STS. Intensity-modulated radiotherapy was associated with lower rates of local progression and may be preferred to less precise forms of delivery.
Clinical relevance: These data may guide clinicians when making decisions regarding dRT for management of STS.
期刊介绍:
Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.