治疗犬软组织肉瘤的手术和术后确定性放射治疗:一项针对 272 只犬(2010-2020 年)的多机构回顾性研究。

IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES Javma-journal of The American Veterinary Medical Association Pub Date : 2024-09-06 DOI:10.2460/javma.24.06.0363
Isabella M Hildebrandt, Owen T Skinner, Megan A Mickelson, Todd E Daniel, Hayley L Ashworth, Annie Kim, Brandan G Wustefeld-Janssens, Tiffany W Martin, Charly McKenna, Michelle L Oblak, Valerie J Poirier, Karanbir Randhawa, Michelle M Turek, Jonathan F McAnulty, Maureen A Griffin, Lillian E Duda, Carlos R Mendez Valenzuela, Isabelle F Vanhaezebrouck, Allyson A Sterman, Christopher Bloom, Laura E Selmic, Dah-Renn Fu, Jishnu Rao Gutti, Koichi Nagata, Brian Thomsen, Arathi Vinayak, Beatrix Jenei, Charles A Maitz
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引用次数: 0

摘要

目的报告软组织肉瘤(STS)手术和术后确定性放疗(dRT)治疗后狗的局部进展和存活率,并评估局部进展和存活率的风险因素:方法:对9家转诊医院2010年1月1日至2020年1月1日期间因STS手术而接受术后dRT治疗的犬只的记录进行回顾性审查。摘录了与发病、手术、dRT、系统治疗和结果相关的数据。结果:共纳入 272 只犬。249只狗报告了组织学分级:102只为1级(40.9%),120只为2级(48.2%),27只为3级(10.8%)。有 56 只狗疑似或确诊为局部进展。1级肿瘤(89只中有24只[26.7%])、2级肿瘤(111只中有23只[20.7%])和3级肿瘤(22只中有6只[27.3%])的局部进展率相似。既往复发(P = .010)和随后的远处转移(P = .014)与更频繁的局部进展有关;与其他形式的放疗相比,调强放疗与局部进展的减少有关(P = .025)。年龄(P = .049)、等级(P = .009)、既往复发(P = .009)和手术机构类型(P = .043)与总生存率有关:结论:大多数患犬的疗效良好;然而,局部进展的频率表明,仍有必要对局部治疗策略进行严格评估,尤其是针对低分级 STS。调强放疗与较低的局部进展率相关,可能比不那么精确的放疗方式更受欢迎:临床相关性:这些数据可为临床医生在决定采用dRT治疗STS时提供指导。
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Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010-2020).

Objective: To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.

Methods: Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted. Selected variables were assessed for association with local progression and overall survival.

Results: 272 dogs were included. Histologic grade was reported in 249 dogs: 102 were grade 1 (40.9%), 120 were grade 2 (48.2%), and 27 were grade 3 (10.8%). Local progression was suspected or confirmed in 56 dogs. Local progression rates were similar for grade 1 (24 of 89 [26.7%]), grade 2 (23 of 111 [20.7%]), and grade 3 tumors (6 of 22 [27.3%]). Previous recurrence (P = .010) and subsequent distant metastasis (P = .014) were associated with more frequent local progression; intensity-modulated radiotherapy was associated with decreased local progression (P = .025) compared to other forms of delivery. Age (P = .049), grade (P = .009), previous recurrence (P = .009), and institution type for surgery (P = .043) were associated with overall survival.

Conclusions: Outcomes for most dogs were good; however, the frequency of local progression indicates an ongoing need to critically appraise local management strategies, particularly for low-grade STS. Intensity-modulated radiotherapy was associated with lower rates of local progression and may be preferred to less precise forms of delivery.

Clinical relevance: These data may guide clinicians when making decisions regarding dRT for management of STS.

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来源期刊
CiteScore
1.60
自引率
15.80%
发文量
539
审稿时长
6-16 weeks
期刊介绍: Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.
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