Javma-journal of The American Veterinary Medical Association最新文献

Objective: To determine whether Miniature Horse mares are predisposed to hemoperitoneum from nonneoplastic ovarian hemorrhage and report the clinical characteristics of this disorder.

Animals: 51 equines with hemoperitoneum, including 22 nonminiature mares and 9 Miniature Horse mares, identified by searching medical records of a tertiary large animal hospital for confirmed hemoperitoneum cases between 2012 and 2023.

Clinical presentation: Signs of hemoperitoneum in miniature mares included lethargy, inappetence, colic, tachycardia, and moderate to severe anemia (PCV ranging from 11% to 19%). Five miniature mares did not survive and were necropsied.

Results: Miniature Horse mares were markedly overrepresented at 29% of hemoperitoneum mares, and no miniature stallions or geldings with hemoperitoneum were identified. In nonminiature mares, hemoperitoneum was attributed to intestinal strangulation (n = 4), suspected or confirmed neoplasia (11), peripartum uterine artery rupture (2), splenic trauma (3), ovarian hematoma (1), and spontaneous broad ligament hematoma (1). In miniature mares, ruptured corpus hemorrhagicum (n = 4) and ovarian hemorrhage (1) were confirmed at necropsy. The other 4 miniature mares survived with no definitive cause of hemoperitoneum identified on extensive diagnostics; 1 was treated for hemoperitoneum again 6 years later, at which time a corpus hemorrhagicum was suspected on ovarian ultrasound. Two miniature mares in first-trimester gestation during treatment for hemoperitoneum subsequently produced normal foals.

Clinical relevance: Ovarian hemorrhage is an uncommon cause of hemoperitoneum in equines; however, it should be considered a likely differential diagnosis for hemoperitoneum in miniature mares, including during pregnancy. Reproductive tract assessment should be performed in equine hemoperitoneum cases, particularly for miniature mares.

Objective: To assess the clinical and immunological effectiveness of resveratrol alone or combined with allopurinol for treating canine visceral leishmaniasis (CVL).

Methods: This study included 50 dogs, 30 diagnosed with CVL and 20 healthy controls. Dogs were classified based on their treatment regime (receiving resveratrol [200 mg/dog/d] and/or allopurinol [10 mg/kg/d]). Clinical scores, anti-leishmanial antibody titers, and routine blood parameters were evaluated on days 0, 15, and 30 after treatment.

Results: Dogs treated with the combination therapy showed the most substantial improvements, with a 75.77% reduction in clinical scores and an 81.25% reduction in antibody titers. Dogs receiving allopurinol exhibited a 56.25% reduction in clinical scores, while those treated with resveratrol showed a 42.82% reduction. Antibody titers were less significantly reduced in the resveratrol group (67.5%) compared to the allopurinol group (45%).

Conclusions: Combining resveratrol with allopurinol enhances the therapeutic efficacy for CVL, leading to significant clinical improvements and reductions in antibody titers. Resveratrol alone also demonstrates promising anti-leishmanial effects.

Clinical relevance: Resveratrol, either alone or in combination with allopurinol, offers a feasible and effective alternative for improving clinical outcomes in CVL. Its incorporation into standard protocols may enhance treatment strategies in veterinary medicine.

Objective: Egg binding is a common and potentially life-threatening disorder in avian species. The aim of this study was to analyze the success rate and associated complications of different treatment approaches for egg binding in parrots.

Methods: All parrots treated in an avian-exclusive veterinary practice for egg binding during an 11-year period (2009 to 2020) were eligible for inclusion in this retrospective study. The primary outcome of the study was resolution of egg binding, defined as removal or laying of the egg and survival at 7 days from presentation.

Results: Of the 150 events that had complete follow-up, 109 (72.7%) resulted in a successful outcome. A successful outcome was observed in 44 of 133 events (33.1%) that were initially managed medically without resorting to additional treatment strategies, in 31 events (86.1%) managed with mechanical assistance, in 20 events (60.6%) managed surgically, and in 12 events (85.7%) managed with ovocentesis. Time from presentation to resolution was a median of 36 hours (range, 1 to 240 hours; n = 119). Multivariable logistic regression demonstrated associations between higher body weight, administration of medical treatment and mechanical assistance, absence of administration of sedation or anesthesia, and absence of obtundation or stupor on presentation with a positive outcome.

Conclusions: Overall, egg binding has a favorable outcome if multiple treatment strategies in addition to medical management are considered.

Clinical relevance: We identified factors associated with resolution and outlined complications of egg binding in parrots, laying the foundation for additional prospective research on this complex condition.

Objective: To investigate the prevalence, risk factors, and economic impact of multidrug-resistant (MDR) infections in dogs at a tertiary referral hospital.

Methods: This was a retrospective cohort study including dogs with positive aerobic culture associated with a traumatic wound or surgical site infection between July 2018 and November 2023. Data collected from medical records included signalment, wound type, culture results, medications (antibiotics, NSAIDs, steroids, immunosuppressives), wound care, hospitalization duration, concurrent illnesses, surgical variables, and cost. Multivariable logistic regression analysis was performed to identify factors associated with MDR development.

Results: 80 dogs met the inclusion criteria, and 19 had MDR infections. Multidrug resistance increased the odds of longer hospitalization duration by 2.98 times (95% CI, 1.09 to 8.19), mortality rates by 11.8 times (95% CI, 1.24 to 112.08), and total costs by 3.57 times (95% CI, 1.3 to 9.83). Steroid use within the past year, NSAID or steroid use within 1 week before culture, and initial preculture use of either penicillin or clindamycin in the past 3 months increased the risk of MDR development by 4.51 to 7.4 times (95% CI, 1.71 to 32.09).

Conclusions: Multidrug-resistant infections were associated with greater mortality, larger costs, and longer hospitalizations. Risk factors for MDR infections included steroid use within the past year, NSAID or steroid use within 1 week before culture, and either penicillin or clindamycin within 3 months before culture.

Clinical relevance: Multidrug-resistant pathogens have clinical and economic impacts on veterinary healthcare, and there is a need to implement standardized surveillance and prevention programs in veterinary hospitals.

Objective: To describe whether infiltration of liposomal bupivacaine (LB) is a risk factor for the development of surgical site infection (SSI) in anal sacculectomy (AS) and compare bacterial isolates from SSIs in animals that received LB and those that did not.

Methods: A medical record review was performed at Colorado State University for dogs undergoing AS between August 2019 and October 2024. Data retrieved included signalment, reason for AS, anesthesia time, additional procedure performed, perioperative and postoperative antibiotic administration, use of LB, development of SSI, and bacterial isolates.

Results: The study population included 105 dogs that underwent a total of 121 ASs. In 18 of 105 cases (17.1%), SSI was noted. For the cases where LB was infiltrated intraoperatively, the rate of SSI was 17.5% (11 of 63). In cases where LB was not used, the rate of SSI was 16.7% (7 of 42). The most common bacterial isolates were Escherichia coli and Enterococcus spp. Of the 10 cultures, 8 had resistance profiles and 2 of 8 (25%) were found to have multidrug-resistant bacteria present, with no difference between the groups.

Conclusions: This study did not show that LB was a significant risk factor for the development of SSI or multidrug-resistant infections.

Clinical relevance: Incisional infiltration of LB does not seem to be associated with a higher rate of SSI or higher rates of multidrug-resistant infections in dogs undergoing AS.

Objective: To determine whether the site of administration of xylazine alters its impact on lidocaine's duration of action when administered as a distal paravertebral block (DPV) in steers.

Methods: 6 healthy steers were used. Unilateral DPVs were performed at L1, L2, and L4. Each steer received 2 treatments in a blinded random crossover study. The local xylazine treatment group received 6 mg of lidocaine/kg mixed with 0.02 mg of xylazine/kg as a DPV, followed by an injection of 0.9% NaCl in the cervical musculature. The systemic xylazine treatment group received 6 mg of lidocaine/kg as a DPV and 0.02 mg of xylazine/kg in the cervical musculature. Sensation was assessed by response to needle pricks along the paralumbar fossa with a 22-gauge hypodermic needle. The time of onset, duration of action, sedation score, and heart rate were compared between treatments. Data are reported as mean ± SD. This study was completed over a 2-week period in May 2023.

Results: The duration of anesthesia was significantly prolonged after DPV in steers treated with local xylazine (186.7 ± 58.7 minutes) compared to systemic xylazine (95 ± 36.3 minutes). Both treatments were associated with mild decreases in heart rate and sedation but were not significantly different between groups.

Conclusions: The addition of xylazine to lidocaine when administered as a DPV provides a longer duration of anesthesia than when xylazine is administered at a distant site to local anesthetic solution deposition.

Clinical relevance: The combination of lidocaine and xylazine when administered as a DPV prolongs the duration of action of lidocaine and is a practical, inexpensive technique.