通过实时 fMRI 训练精神分裂症患者获得对心智理论网络的意志控制:试点研究

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2024-09-07 DOI:10.1016/j.scog.2024.100329
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引用次数: 0

摘要

被诊断为精神分裂症谱系障碍(SSD)的患者通常会表现出思维理论网络(ToM-N)的改变。在这项概念验证、单臂试验研究中,我们调查了患有精神分裂症谱系障碍的参与者(N = 7)是否能够学会自愿控制 ToM-N 的区域(左/中/外侧前额叶皮层 [D/M/VMPFC]、左颞顶交界处 [LTPJ]、楔前区 [PC]、右颞上沟 [RSTS] 和右颞顶交界处 [RTPJ])。兴趣区分析表明,经过神经反馈训练后,参与者能够在没有主动反馈的转移任务中获得以下 ToM-N 脑区的意志控制:右颞顶交界区、楔前区和背/内侧前额叶皮层(神经反馈效应 Fs > 6.17, ps <.05)。这些研究结果表明,通过rtfMRI神经反馈,训练对ToM-N的意志控制在SSD中是初步可行的,尽管研究结果还需要通过更稳健的设计(包括对照组和更大的样本)来重复。
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Training individuals with schizophrenia to gain volitional control of the theory of mind network with real-time fMRI: A pilot study

Individuals diagnosed with schizophrenia spectrum disorders (SSDs) often demonstrate alterations in the Theory of Mind Network (ToM-N). Here, in this proof-of-concept, single-arm pilot study, we investigate whether participants with an SSD (N = 7) were able to learn to volitionally control regions of the ToM-N (dorso/middle/ventromedial prefrontal cortex [D/M/VMPFC], left temporoparietal junction [LTPJ], precuneus [PC], right superior temporal sulcus [RSTS], and right temporoparietal junction [RTPJ]) using real-time fMRI neurofeedback (rtfMRI-NF). Region-of-interest analyses demonstrate that after neurofeedback training, participants were able to gain volitional control in the following ToM-N brain regions during the transfer task, where no active feedback was given: right temporoparietal junction, precuneus, and dorso/ventromedial prefrontal cortex (neurofeedback effect Fs > 6.17, ps < .05). These findings suggest that trained volitional control over the ToM-N is tentatively feasible with rtfMRI neurofeedback in SSD, although findings need to be replicated with more robust designs that include a control group and larger samples.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
期刊最新文献
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