Ajamaluddin Malik , Abdulaziz Alamri , Javed Masood Khan , Nojood Altwaijry , Abir Alamro , Abdullah S. Alhomida , Hamza Odeibat , Mohammad Shamsul Ola
{"title":"金属纳米粒子对血清白蛋白结构完整性影响的温度依赖性研究","authors":"Ajamaluddin Malik , Abdulaziz Alamri , Javed Masood Khan , Nojood Altwaijry , Abir Alamro , Abdullah S. Alhomida , Hamza Odeibat , Mohammad Shamsul Ola","doi":"10.1016/j.jksus.2024.103419","DOIUrl":null,"url":null,"abstract":"<div><p>Nanoparticles (NPs) have distinct properties due to their small size and high surface area-to-volume ratio. These characteristics result in unique features not seen in bulk materials. Metals, semiconductors, and polymers are among the many varieties. Nanomaterials are used in various industries, including medical, electronics, and environmental cleanup. However, their potential environmental and health consequences must be carefully considered. Metal nanoparticles (MNPs) have received significant attention due to their outstanding physicochemical features and diverse applications in various sectors. MNPs are utilized in different fields, from electronics to health. Previously, the effect of various metal nanoparticles on the structure, stability, and functionality of metabolic enzymes was investigated. Copper (Cu) NPs were found to have significant negative impacts on these enzymes. The focus of the current investigation turned to serum albumin, a vital plasma protein containing oxidized cysteine residues. The findings demonstrated that NPs had a minor impact on the structure and stability of serum albumin, in contrast to the effects observed on reduced cysteine-containing enzymes.</p></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 9","pages":"Article 103419"},"PeriodicalIF":3.7000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1018364724003318/pdfft?md5=6d8f656608a97fa30650345a66e10e81&pid=1-s2.0-S1018364724003318-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A temperature-dependent investigation of the impact of metal nanoparticles on the structural integrity of serum albumin\",\"authors\":\"Ajamaluddin Malik , Abdulaziz Alamri , Javed Masood Khan , Nojood Altwaijry , Abir Alamro , Abdullah S. Alhomida , Hamza Odeibat , Mohammad Shamsul Ola\",\"doi\":\"10.1016/j.jksus.2024.103419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nanoparticles (NPs) have distinct properties due to their small size and high surface area-to-volume ratio. These characteristics result in unique features not seen in bulk materials. Metals, semiconductors, and polymers are among the many varieties. Nanomaterials are used in various industries, including medical, electronics, and environmental cleanup. However, their potential environmental and health consequences must be carefully considered. Metal nanoparticles (MNPs) have received significant attention due to their outstanding physicochemical features and diverse applications in various sectors. MNPs are utilized in different fields, from electronics to health. Previously, the effect of various metal nanoparticles on the structure, stability, and functionality of metabolic enzymes was investigated. Copper (Cu) NPs were found to have significant negative impacts on these enzymes. The focus of the current investigation turned to serum albumin, a vital plasma protein containing oxidized cysteine residues. The findings demonstrated that NPs had a minor impact on the structure and stability of serum albumin, in contrast to the effects observed on reduced cysteine-containing enzymes.</p></div>\",\"PeriodicalId\":16205,\"journal\":{\"name\":\"Journal of King Saud University - Science\",\"volume\":\"36 9\",\"pages\":\"Article 103419\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1018364724003318/pdfft?md5=6d8f656608a97fa30650345a66e10e81&pid=1-s2.0-S1018364724003318-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of King Saud University - Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1018364724003318\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of King Saud University - Science","FirstCategoryId":"103","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1018364724003318","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
A temperature-dependent investigation of the impact of metal nanoparticles on the structural integrity of serum albumin
Nanoparticles (NPs) have distinct properties due to their small size and high surface area-to-volume ratio. These characteristics result in unique features not seen in bulk materials. Metals, semiconductors, and polymers are among the many varieties. Nanomaterials are used in various industries, including medical, electronics, and environmental cleanup. However, their potential environmental and health consequences must be carefully considered. Metal nanoparticles (MNPs) have received significant attention due to their outstanding physicochemical features and diverse applications in various sectors. MNPs are utilized in different fields, from electronics to health. Previously, the effect of various metal nanoparticles on the structure, stability, and functionality of metabolic enzymes was investigated. Copper (Cu) NPs were found to have significant negative impacts on these enzymes. The focus of the current investigation turned to serum albumin, a vital plasma protein containing oxidized cysteine residues. The findings demonstrated that NPs had a minor impact on the structure and stability of serum albumin, in contrast to the effects observed on reduced cysteine-containing enzymes.
期刊介绍:
Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.