金属纳米粒子对血清白蛋白结构完整性影响的温度依赖性研究

IF 3.7 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Journal of King Saud University - Science Pub Date : 2024-09-02 DOI:10.1016/j.jksus.2024.103419
Ajamaluddin Malik , Abdulaziz Alamri , Javed Masood Khan , Nojood Altwaijry , Abir Alamro , Abdullah S. Alhomida , Hamza Odeibat , Mohammad Shamsul Ola
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引用次数: 0

摘要

纳米颗粒(NPs)因其尺寸小、表面积与体积比高而具有独特的特性。这些特性造就了散装材料所不具备的独特功能。金属、半导体和聚合物是纳米材料的众多种类之一。纳米材料广泛应用于各行各业,包括医疗、电子和环境清洁。然而,必须仔细考虑其潜在的环境和健康后果。金属纳米粒子(MNPs)因其出色的物理化学特性和在各行各业的广泛应用而备受关注。MNPs 可用于从电子到健康等不同领域。此前,人们研究了各种金属纳米粒子对代谢酶的结构、稳定性和功能性的影响。研究发现,铜(Cu)纳米粒子对这些酶有显著的负面影响。目前的研究重点转向血清白蛋白,这是一种含有氧化半胱氨酸残基的重要血浆蛋白。研究结果表明,NPs 对血清白蛋白的结构和稳定性影响较小,而对含有还原半胱氨酸的酶的影响则不同。
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A temperature-dependent investigation of the impact of metal nanoparticles on the structural integrity of serum albumin

Nanoparticles (NPs) have distinct properties due to their small size and high surface area-to-volume ratio. These characteristics result in unique features not seen in bulk materials. Metals, semiconductors, and polymers are among the many varieties. Nanomaterials are used in various industries, including medical, electronics, and environmental cleanup. However, their potential environmental and health consequences must be carefully considered. Metal nanoparticles (MNPs) have received significant attention due to their outstanding physicochemical features and diverse applications in various sectors. MNPs are utilized in different fields, from electronics to health. Previously, the effect of various metal nanoparticles on the structure, stability, and functionality of metabolic enzymes was investigated. Copper (Cu) NPs were found to have significant negative impacts on these enzymes. The focus of the current investigation turned to serum albumin, a vital plasma protein containing oxidized cysteine residues. The findings demonstrated that NPs had a minor impact on the structure and stability of serum albumin, in contrast to the effects observed on reduced cysteine-containing enzymes.

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来源期刊
Journal of King Saud University - Science
Journal of King Saud University - Science Multidisciplinary-Multidisciplinary
CiteScore
7.20
自引率
2.60%
发文量
642
审稿时长
49 days
期刊介绍: Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.
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