Bianca Bălaș-Maftei, Carmen-Elena Florea, Maria Obreja, Alexandra Rotaru, Larisa Miftode, Egidia Miftode, Erika-Raluca Irimie-Băluță, Carmen Manciuc
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引用次数: 0
摘要
梭状芽孢杆菌属包括超过 180 种革兰氏阳性厌氧芽孢杆菌。在特定条件下,这些细菌可引起人类多种侵袭性感染。副产气荚膜梭菌存在于肠道共生菌群中,相关的菌血症通常继发于肠粘膜损伤和存在胃肠道疾病、恶性肿瘤、糖尿病、艾滋病病毒感染或中性粒细胞减少症等易感病症。本研究中的病例是一名 70 岁的男性患者,他是一名生活贫困的农村居民,有饮酒史和心血管病史。通过连续的检查排除了几个初步诊断和后续诊断(如中风、脑膜炎、局部破伤风)。血液培养最终发现副猪梭状芽孢杆菌呈阳性,尽管使用甲硝唑和青霉素 G 进行治疗,患者还是出现了脓毒性休克。
Diagnosis and treatment challenges in a rare Clostridium infection: A case report.
The Clostridium genus includes >180 species of Gram-positive, anaerobic, sporulating bacteria. Under certain conditions, these can cause a wide range of invasive infections in humans. Clostridium paraputrificum occurs in the commensal intestinal flora and related bacteremia typically occurs secondary to an injury to the intestinal mucosa and in the presence of predisposing conditions, such as gastrointestinal disorders, malignancies, diabetes, HIV infection or neutropenia. The current study presents the case of a 70-year-old male patient, a rural resident living in poverty, with a history of alchohol consumption and cardiovascular pathology. Several initial and subsequent diagnoses were ruled out by successive investigations (e.g., stroke, meningitis, localized tetanus). Blood cultures were eventually found positive for Clostridium paraputrificum and the patient developed septic shock despite treatment with metronidazole and penicillin G. Once switched to carbapenem, the patient progressed favorably, suggesting that carbapenem could work as a first-line antibiotic treatment for Clostridium paraputrificum infections.
期刊介绍:
Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.