根据 COVID-19 严重程度和 COVID-19 急性后遗症对常见病毒的抗体反应。

IF 6.8 3区 医学 Q1 VIROLOGY Journal of Medical Virology Pub Date : 2024-09-09 DOI:10.1002/jmv.29862
Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia-Aymerich, Rafael de Cid, Carlota Dobaño, Gemma Moncunill, Manolis Kogevinas
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引用次数: 0

摘要

有限的研究表明,某些病毒会在重症急性呼吸综合征-冠状病毒 2 感染后重新活化,导致 COVID-19 急性后遗症 (PASC) 的发生。我们对人群队列中的 1083 名感染者进行了研究,并根据既往 COVID-19 和 PASC 病史的严重程度评估了血浆中针对 Epstein-Barr 病毒 (EBV)、巨细胞病毒、水痘带状疱疹病毒 (VZV)、BK 多瘤病毒、KI 多瘤病毒、WU 多瘤病毒 (WUPyV)、呼吸道合胞病毒和 Adv-36 的免疫球蛋白 (Ig)G 和免疫球蛋白 A 水平的差异。经历过严重 COVID-19 的人对潜伏病毒的抗体反应较高。即使在没有经历过严重 COVID-19 的个体中,曾经发生过 PASC、活动性持续 PASC 和伴有神经精神症状的 PASC 与 EBV 早期抗原弥漫型、VZV 和 WUPyV 较高的免疫球蛋白 G 相关。
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Antibody responses to common viruses according to COVID-19 severity and postacute sequelae of COVID-19

Limited research suggests that certain viruses reactivate in severe-acute-respiratory-syndrome-coronavirus 2 infection, contributing to the development of postacute sequelae of COVID-19 (PASC). We examined 1083 infected individuals from a population-based cohort, and assessed differences in plasma immunoglobulin (Ig)G and immunoglobulin A levels against Epstein-Barr virus (EBV), cytomegalovirus, varicella zoster virus (VZV), BK polyomavirus, KI polyomavirus, WU polyomavirus (WUPyV), respiratory syncytial virus, and Adv-36 according to the severity of previous COVID-19 and PASC history. Individuals who had experienced severe COVID-19 had higher antibody responses to latent viruses. Ever PASC, active persistent PASC, and PASC with neuropsychiatric symptoms were associated with higher immnoglobulin G to EBV early antigen-diffuse, VZV, and WUPyV even among individuals without previous severe COVID-19.

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来源期刊
Journal of Medical Virology
Journal of Medical Virology 医学-病毒学
CiteScore
23.20
自引率
2.40%
发文量
777
审稿时长
1 months
期刊介绍: The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.
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