DCSGMDA: A dual-channel convolutional model based on stacked deep learning collaborative gradient decomposition for predicting miRNA-disease associations

Numerous studies have shown that microRNAs (miRNAs) play a key role in human diseases as critical biomarkers. Its abnormal expression is often accompanied by the emergence of specific diseases. Therefore, studying the relationship between miRNAs and diseases can deepen the insights of their pathogenesis, grasp the process of disease onset and development, and promote drug research of specific diseases. However, many undiscovered relationships between miRNAs and diseases remain, significantly limiting research on miRNA-disease correlations. To explore more potential correlations, we propose a dual-channel convolutional model based on stacked deep learning collaborative gradient decomposition for predicting miRNA-disease associations (DCSGMDA). Firstly, we constructed similarity networks for miRNAs and diseases, as well as an association relationship network. Secondly, potential features were fully mined using stacked deep learning and gradient decomposition networks, along with dual-channel convolutional neural networks. Finally, correlations were scored by a multilayer perceptron. We performed 5-fold and 10-fold cross-validation experiments on DCSGMDA using two datasets based on the Human MicroRNA Disease Database (HMDD). Additionally, parametric, ablation, and comparative experiments, along with case studies, were conducted. The experimental results demonstrate that DCSGMDA performs well in predicting miRNA-disease associations.