皮层表面迷走神经刺激诱发电位的无标记功能成像

Laura RoaFiore, Trevor Meyer, Thaissa Peixoto, Pedro Irazoqui
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摘要

迷走神经刺激(VNS)是美国食品与药物管理局(FDA)批准的一种刺激疗法,用于治疗难治性癫痫患者。在这项工作中,我们使用相干全息成像系统来描述大脑皮层中迷走神经诱发电位(VEP)对 VNS 刺激范式的反应,而无需放置电极或任何遗传、结构或功能标签。我们分析了高达饱和的刺激幅度、高达 800 μs 的脉冲宽度以及从 10 Hz 到 30 Hz 的频率,发现刺激幅度对 VEPs 反应幅度有强烈的调节作用(效应大小为 0.401),而脉冲宽度对诱发电位幅度有适度的调节作用(效应大小为 0.127),频率几乎没有调节作用(效应大小为 0.009)。我们发现脉冲宽度和频率之间存在轻微的相互作用。这种非接触式无标记功能成像技术可作为一种无创快速反馈工具来描述 VEPs,并可提高 VNS 对难治性癫痫患者的疗效。
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Label-free functional imaging of vagus nerve stimulation-evoked potentials at the cortical surface
Vagus nerve stimulation (VNS) is an FDA-approved stimulation therapy to treat patients with refractory epilepsy. In this work, we use a coherent holographic imaging system to characterize vagus nerve-evoked potentials (VEPs) in the cortex in response to VNS stimulation paradigms without electrode placement or any genetic, structural, or functional labels. We analyze stimulation amplitude up to saturation, pulse width up to 800 μs, and frequency from 10 Hz to 30 Hz, finding that stimulation amplitude strongly modulates VEPs response magnitude (effect size 0.401), while pulse width has a moderate modulatory effect (effect size 0.127) and frequency has almost no modulatory effect (effect size 0.009) on the evoked potential magnitude. We find mild interactions between pulse width and frequency. This non-contact label-free functional imaging technique may serve as a non-invasive rapid-feedback tool to characterize VEPs and may increase the efficacy of VNS in patients with refractory epilepsy.
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