Pub Date : 2025-01-01Epub Date: 2025-01-16DOI: 10.1038/s44328-024-00018-7
Annie Yang-Schulz, Maria Zacharopoulou, Sema Zeynep Yilmaz, Anupam Banerjee, Satyaki Saha, Daniel Nietlispach, Michael Ohlmeyer, Mert Gur, Laura S Itzhaki, Ivet Bahar, Reuven Gordon
The reactivation of heterotrimeric protein phosphatase 2A (PP2A) through small molecule activators is of interest to therapeutic intervention due to its dysregulation, which is linked to chronic conditions. This study focuses on the PP2A scaffold subunit PR65 and a small molecule activator, ATUX-8385, designed to bind directly to this subunit. Using a label-free single-molecule approach with nanoaperture optical tweezers (NOT), we quantify its binding, obtaining a dissociation constant of 13.6 ± 2.5 μM, consistent with ensemble fluorescence anisotropy results but challenging to achieve with other methods due to low affinity. Single-molecule NOT measurements reveal that binding increases optical scattering, indicating PR65 elongation. This interpretation is supported by all-atom molecular dynamics simulations showing PR65 adopts more extended conformations upon binding. This work highlights NOT's utility in quantifying binding kinetics and structural impact, offering insights valuable for drug discovery.
{"title":"Direct observation of small molecule activator binding to single PR65 protein.","authors":"Annie Yang-Schulz, Maria Zacharopoulou, Sema Zeynep Yilmaz, Anupam Banerjee, Satyaki Saha, Daniel Nietlispach, Michael Ohlmeyer, Mert Gur, Laura S Itzhaki, Ivet Bahar, Reuven Gordon","doi":"10.1038/s44328-024-00018-7","DOIUrl":"10.1038/s44328-024-00018-7","url":null,"abstract":"<p><p>The reactivation of heterotrimeric protein phosphatase 2A (PP2A) through small molecule activators is of interest to therapeutic intervention due to its dysregulation, which is linked to chronic conditions. This study focuses on the PP2A scaffold subunit PR65 and a small molecule activator, ATUX-8385, designed to bind directly to this subunit. Using a label-free single-molecule approach with nanoaperture optical tweezers (NOT), we quantify its binding, obtaining a dissociation constant of 13.6 ± 2.5 μM, consistent with ensemble fluorescence anisotropy results but challenging to achieve with other methods due to low affinity. Single-molecule NOT measurements reveal that binding increases optical scattering, indicating PR65 elongation. This interpretation is supported by all-atom molecular dynamics simulations showing PR65 adopts more extended conformations upon binding. This work highlights NOT's utility in quantifying binding kinetics and structural impact, offering insights valuable for drug discovery.</p>","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":"2 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-01-31DOI: 10.1038/s44328-024-00021-y
David A M Colburn, Terry L Chern, Vincent E Guo, Kennedy A Salamat, Daniel N Pugliese, Corey K Bradley, Daichi Shimbo, Samuel K Sia
Cuffless noninvasive blood pressure (BP) measurement could enable early unobtrusive detection of abnormal BP patterns, but when the sensor is placed on a location away from heart level (such as the arm), its accuracy is compromised by variations in the position of the sensor relative to heart level; such positional variations produce hydrostatic pressure changes that can cause swings in tens of mmHg in the measured BP if uncorrected. A standard method to correct for changes in hydrostatic pressure makes use of a bulky fluid-filled tube connecting heart level to the sensor. Here, we present an alternative method to correct for variations in hydrostatic pressure using unobtrusive wearable inertial sensors. This method, called IMU-Track, analyzes motion information with a deep learning model; for sensors placed on the arm, IMU-Track calculates parameterized arm-pose coordinates, which are then used to correct the measured BP. We demonstrated IMU-Track for BP measurements derived from pulse transit time, acquired using electrocardiography and finger photoplethysmography, with validation data collected across 20 participants. Across these participants, for the hand heights of 25 cm below or above the heart, mean absolute errors were reduced for systolic BP from 13.5 ± 1.1 and 9.6 ± 1.1 to 5.9 ± 0.7 and 5.9 ± 0.5 mmHg, respectively, and were reduced for diastolic BP from 15.0 ± 1.0 and 11.5 ± 1.5 to 6.8 ± 0.5 and 7.8 ± 0.8, respectively. On a commercial smartphone, the arm-tracking inference time was ~134 ms, sufficiently fast for real-time hydrostatic pressure correction. This method for correcting hydrostatic pressure may enable accurate passive cuffless BP monitors placed at positions away from heart level that accommodate everyday movements.
{"title":"A method for blood pressure hydrostatic pressure correction using wearable inertial sensors and deep learning.","authors":"David A M Colburn, Terry L Chern, Vincent E Guo, Kennedy A Salamat, Daniel N Pugliese, Corey K Bradley, Daichi Shimbo, Samuel K Sia","doi":"10.1038/s44328-024-00021-y","DOIUrl":"10.1038/s44328-024-00021-y","url":null,"abstract":"<p><p>Cuffless noninvasive blood pressure (BP) measurement could enable early unobtrusive detection of abnormal BP patterns, but when the sensor is placed on a location away from heart level (such as the arm), its accuracy is compromised by variations in the position of the sensor relative to heart level; such positional variations produce hydrostatic pressure changes that can cause swings in tens of mmHg in the measured BP if uncorrected. A standard method to correct for changes in hydrostatic pressure makes use of a bulky fluid-filled tube connecting heart level to the sensor. Here, we present an alternative method to correct for variations in hydrostatic pressure using unobtrusive wearable inertial sensors. This method, called IMU-Track, analyzes motion information with a deep learning model; for sensors placed on the arm, IMU-Track calculates parameterized arm-pose coordinates, which are then used to correct the measured BP. We demonstrated IMU-Track for BP measurements derived from pulse transit time, acquired using electrocardiography and finger photoplethysmography, with validation data collected across 20 participants. Across these participants, for the hand heights of 25 cm below or above the heart, mean absolute errors were reduced for systolic BP from 13.5 ± 1.1 and 9.6 ± 1.1 to 5.9 ± 0.7 and 5.9 ± 0.5 mmHg, respectively, and were reduced for diastolic BP from 15.0 ± 1.0 and 11.5 ± 1.5 to 6.8 ± 0.5 and 7.8 ± 0.8, respectively. On a commercial smartphone, the arm-tracking inference time was ~134 ms, sufficiently fast for real-time hydrostatic pressure correction. This method for correcting hydrostatic pressure may enable accurate passive cuffless BP monitors placed at positions away from heart level that accommodate everyday movements.</p>","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":"2 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1038/s44328-024-00022-x
Vaibhav B. Yadav, Enosh Lim, Alison H. Skalet, Mohammad J. Moghimi
Uveal melanoma is the most common primary intraocular cancer in adults and is an aggressive malignancy with risk to vision and survival. Early detection and timely management of tumors may help preserve vision and reduce mortality rate but is challenging as many tumors are asymptomatic until they become large. Here, we studied the electrical properties of eyes to investigate a novel method for potentially detecting small intraocular tumors. We used finite element analysis to simulate the impact of uveal melanoma tumors on electrical impedance and current density in eye models. We also measured the impedance and current flow in the presence of inserted tissue simulating an intraocular tumor in enucleated bovine eyes and eyes in bovine head ex vivo. Our results showed that a 5 mm-diameter mass was detected inside a 32-mm diameter bovine eye by the impedance analyzer.
{"title":"Evaluation of electrical impedance spectroscopy of bovine eyes for early detection of uveal melanoma","authors":"Vaibhav B. Yadav, Enosh Lim, Alison H. Skalet, Mohammad J. Moghimi","doi":"10.1038/s44328-024-00022-x","DOIUrl":"10.1038/s44328-024-00022-x","url":null,"abstract":"Uveal melanoma is the most common primary intraocular cancer in adults and is an aggressive malignancy with risk to vision and survival. Early detection and timely management of tumors may help preserve vision and reduce mortality rate but is challenging as many tumors are asymptomatic until they become large. Here, we studied the electrical properties of eyes to investigate a novel method for potentially detecting small intraocular tumors. We used finite element analysis to simulate the impact of uveal melanoma tumors on electrical impedance and current density in eye models. We also measured the impedance and current flow in the presence of inserted tissue simulating an intraocular tumor in enucleated bovine eyes and eyes in bovine head ex vivo. Our results showed that a 5 mm-diameter mass was detected inside a 32-mm diameter bovine eye by the impedance analyzer.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00022-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-26DOI: 10.1038/s44328-024-00019-6
Simão Monteiro Belo dos Santos, Celine Wegsteen, Dries Vloemans, Matthias Corion, Bart De Ketelaere, Dragana Spasic, Jeroen Lammertyn
Several European countries have implemented legislations to eliminate day-old male chicks killing. Although embryo sexing (in ovo sexing) is the most promising alternative, no current solution can handle all egg colors with >98% sexing accuracy, low cost and minimal embryo disturbance before day 13 of incubation and processing >20,000 eggs/hour. Recombinase polymerase amplification (RPA) presents a promising alternative to PCR that can be integrated into microfluidic platforms. In this work, we developed fully autonomous microfluidic cartridge (SIMPLE-RPA chip) for female chick-specific synthetic HINTW gene detection in 30 min at 37.7 °C inside an egg incubator. We first optimized off-chip RPA, allowing for highly sensitive DNA detection (1.6 × 10–5 ng/µL). The SIMPLE-RPA chip was developed to automate the RPA bioassay on-chip, reducing user errors, and contamination risks and maintaining the off-chip LOD while offering low price, small footprint, upscaling compatibility, and easy transfer to other point-of-care applications.
{"title":"Fully automated sample to result SIMPLE RPA microfluidic chip towards in ovo sexing application","authors":"Simão Monteiro Belo dos Santos, Celine Wegsteen, Dries Vloemans, Matthias Corion, Bart De Ketelaere, Dragana Spasic, Jeroen Lammertyn","doi":"10.1038/s44328-024-00019-6","DOIUrl":"10.1038/s44328-024-00019-6","url":null,"abstract":"Several European countries have implemented legislations to eliminate day-old male chicks killing. Although embryo sexing (in ovo sexing) is the most promising alternative, no current solution can handle all egg colors with >98% sexing accuracy, low cost and minimal embryo disturbance before day 13 of incubation and processing >20,000 eggs/hour. Recombinase polymerase amplification (RPA) presents a promising alternative to PCR that can be integrated into microfluidic platforms. In this work, we developed fully autonomous microfluidic cartridge (SIMPLE-RPA chip) for female chick-specific synthetic HINTW gene detection in 30 min at 37.7 °C inside an egg incubator. We first optimized off-chip RPA, allowing for highly sensitive DNA detection (1.6 × 10–5 ng/µL). The SIMPLE-RPA chip was developed to automate the RPA bioassay on-chip, reducing user errors, and contamination risks and maintaining the off-chip LOD while offering low price, small footprint, upscaling compatibility, and easy transfer to other point-of-care applications.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00019-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-13DOI: 10.1038/s44328-024-00016-9
Aayushi Laliwala, Ashruti Pant, Denis Svechkarev, Marat R. Sadykov, Aaron M. Mohs
Evolution of antimicrobial-resistant bacterial species is on a rise. This review aims to explore the diverse range of paper-based platforms designed to identify antimicrobial-resistant bacterial species. It highlights the most important targets used for sensor development and examines the applications of nanosized particles used in paper-based sensors. This review also discusses the advantages, limitations, and applicability of various targets and detection techniques for sensing drug-resistant bacterial species using paper-based platforms.
{"title":"Advancements of paper-based sensors for antibiotic-resistant bacterial species identification","authors":"Aayushi Laliwala, Ashruti Pant, Denis Svechkarev, Marat R. Sadykov, Aaron M. Mohs","doi":"10.1038/s44328-024-00016-9","DOIUrl":"10.1038/s44328-024-00016-9","url":null,"abstract":"Evolution of antimicrobial-resistant bacterial species is on a rise. This review aims to explore the diverse range of paper-based platforms designed to identify antimicrobial-resistant bacterial species. It highlights the most important targets used for sensor development and examines the applications of nanosized particles used in paper-based sensors. This review also discusses the advantages, limitations, and applicability of various targets and detection techniques for sensing drug-resistant bacterial species using paper-based platforms.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00016-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1038/s44328-024-00017-8
Ana Lopez-Campistrous, Hillary Sweet, Ciaran Terry, Craig Garen, Yu Wan, Robert E. Burrell, Kyle Moxham, Matthew Nickel, Michael Serpe, Michael Joyce, Lorne Tyrrell, Todd P. W. McMullen
The vast array of immunoassay technologies used to assess protein interactions is costly or platform-specific. We present a label-free visual interference colour assay (VICA) that quantifies peptide and protein interactions by creating an iridescent surface allowing direct visualisation without spectrophotometric optics or microfluidics. A nanoporous aluminium oxide surface is tuned to match the refractive indices of the overlying protein layers to generate visual interference colours. To functionalise the surface, we created an affinity-capture system using a protein A-carboxyglutamic (GLA) construct that orients antibodies to enhance the signal. Using off-the-shelf antibodies, the platform can isolate analytes in buffer, whole blood, or serum. This surface generates a discernible colour change at concentrations as low as 50 femtomoles/mm2 and can monitor oligomer formation in sequential steps on the same slide. VICA provides comparable kinetic parameters to biolayer interferometry and traditional immunoassays while also allowing characterisation of proteins in large macromolecular complexes.
{"title":"A quantitative, label-free visual interference colour assay platform for protein targeting and binding assays","authors":"Ana Lopez-Campistrous, Hillary Sweet, Ciaran Terry, Craig Garen, Yu Wan, Robert E. Burrell, Kyle Moxham, Matthew Nickel, Michael Serpe, Michael Joyce, Lorne Tyrrell, Todd P. W. McMullen","doi":"10.1038/s44328-024-00017-8","DOIUrl":"10.1038/s44328-024-00017-8","url":null,"abstract":"The vast array of immunoassay technologies used to assess protein interactions is costly or platform-specific. We present a label-free visual interference colour assay (VICA) that quantifies peptide and protein interactions by creating an iridescent surface allowing direct visualisation without spectrophotometric optics or microfluidics. A nanoporous aluminium oxide surface is tuned to match the refractive indices of the overlying protein layers to generate visual interference colours. To functionalise the surface, we created an affinity-capture system using a protein A-carboxyglutamic (GLA) construct that orients antibodies to enhance the signal. Using off-the-shelf antibodies, the platform can isolate analytes in buffer, whole blood, or serum. This surface generates a discernible colour change at concentrations as low as 50 femtomoles/mm2 and can monitor oligomer formation in sequential steps on the same slide. VICA provides comparable kinetic parameters to biolayer interferometry and traditional immunoassays while also allowing characterisation of proteins in large macromolecular complexes.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00017-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-21DOI: 10.1038/s44328-024-00015-w
Ebin Joseph, Manuela Ciocca, Haodong Wu, Serena Marcozzi, Maria Assunta Ucci, Kavya Keremane, Luyao Zheng, Bed Poudel, Congcong Wu, Antonella Camaioni, Kai Wang, Shashank Priya, Thomas M. Brown
This review covers advancements in biosensing, biophotovoltaics, and photobiomodulation, focusing on the synergistic use of light, biomaterials, cells or tissues, interfaced with photosensitive dye-sensitized, perovskite, and conjugated polymer organic semiconductors or nanoparticles. Integration of semiconductor and biological systems, using non-invasive light-probes or -stimuli for both sensing and controlling biological behavior, has led to groundbreaking applications like artificial retinas. From fusion of photovoltaics and biology, a new research field emerges: photovoltaic bioelectronics.
{"title":"Photovoltaic bioelectronics merging biology with new generation semiconductors and light in biophotovoltaics photobiomodulation and biosensing","authors":"Ebin Joseph, Manuela Ciocca, Haodong Wu, Serena Marcozzi, Maria Assunta Ucci, Kavya Keremane, Luyao Zheng, Bed Poudel, Congcong Wu, Antonella Camaioni, Kai Wang, Shashank Priya, Thomas M. Brown","doi":"10.1038/s44328-024-00015-w","DOIUrl":"10.1038/s44328-024-00015-w","url":null,"abstract":"This review covers advancements in biosensing, biophotovoltaics, and photobiomodulation, focusing on the synergistic use of light, biomaterials, cells or tissues, interfaced with photosensitive dye-sensitized, perovskite, and conjugated polymer organic semiconductors or nanoparticles. Integration of semiconductor and biological systems, using non-invasive light-probes or -stimuli for both sensing and controlling biological behavior, has led to groundbreaking applications like artificial retinas. From fusion of photovoltaics and biology, a new research field emerges: photovoltaic bioelectronics.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-44"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00015-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-06DOI: 10.1038/s44328-024-00014-x
Matthew Peters, Tianyu Zhao, Sherin George, Viet Giang Truong, Síle Nic Chormaic, Cuifeng Ying, René A. Nome, Reuven Gordon
Resolving the free energy landscapes that govern protein biophysics has been obscured by ensemble averaging. While the folding dynamics of single proteins have been observed using fluorescent labels and/or tethers, a simpler and more direct measurement of the conformational changes would not require modifications to the protein. We use nanoaperture optical tweezers to resolve the energy landscape of a single unmodified protein, Bovine Serum Albumin (BSA), and quantify changes in the three-state conformation dynamics with temperature. A Markov model with Kramers’ theory transition rates is used to model the dynamics, showing good agreement with the observed state transitions. This first look at the intrinsic energy landscape of proteins provides a transformative tool for protein biophysics and may be applied broadly, including mapping out the energy landscape of particularly challenging intrinsically disordered proteins.
{"title":"Energy landscape of conformational changes for a single unmodified protein","authors":"Matthew Peters, Tianyu Zhao, Sherin George, Viet Giang Truong, Síle Nic Chormaic, Cuifeng Ying, René A. Nome, Reuven Gordon","doi":"10.1038/s44328-024-00014-x","DOIUrl":"10.1038/s44328-024-00014-x","url":null,"abstract":"Resolving the free energy landscapes that govern protein biophysics has been obscured by ensemble averaging. While the folding dynamics of single proteins have been observed using fluorescent labels and/or tethers, a simpler and more direct measurement of the conformational changes would not require modifications to the protein. We use nanoaperture optical tweezers to resolve the energy landscape of a single unmodified protein, Bovine Serum Albumin (BSA), and quantify changes in the three-state conformation dynamics with temperature. A Markov model with Kramers’ theory transition rates is used to model the dynamics, showing good agreement with the observed state transitions. This first look at the intrinsic energy landscape of proteins provides a transformative tool for protein biophysics and may be applied broadly, including mapping out the energy landscape of particularly challenging intrinsically disordered proteins.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00014-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-04DOI: 10.1038/s44328-024-00011-0
Kuldeep Kaswan, Meenakshi Ray, Arshad Khan, Yu-Lin Wang, Zong-Hong Lin
Solid-liquid triboelectric nanogenerators (SL-TENGs) exhibit significant potential in energy harvesting and sensing. This review explores SL-TENG development, focusing on chemical sensing and biosensing applications. Initially, the working mechanisms of various SL-TENG modes are described. Subsequently, an analysis of surface modifications of contact surfaces and liquids to functionalize chemical sensing and biosensing is explored, including their impact on surface properties and the corresponding effect on device performance related to sensing applications.
{"title":"Recent advances in solid-liquid triboelectric nanogenerators for self-powered chemical and biological sensing","authors":"Kuldeep Kaswan, Meenakshi Ray, Arshad Khan, Yu-Lin Wang, Zong-Hong Lin","doi":"10.1038/s44328-024-00011-0","DOIUrl":"10.1038/s44328-024-00011-0","url":null,"abstract":"Solid-liquid triboelectric nanogenerators (SL-TENGs) exhibit significant potential in energy harvesting and sensing. This review explores SL-TENG development, focusing on chemical sensing and biosensing applications. Initially, the working mechanisms of various SL-TENG modes are described. Subsequently, an analysis of surface modifications of contact surfaces and liquids to functionalize chemical sensing and biosensing is explored, including their impact on surface properties and the corresponding effect on device performance related to sensing applications.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00011-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1038/s44328-024-00013-y
Karmen Markov, Mohamed Elgendi, Carlo Menon
The rise of wearable technology has led to EEG-based sleep monitoring devices that use electrodes placed on the forehead, ear, or neck. These devices offer promising applications in clinical and healthy populations by comparing sleep patterns, monitoring intervention responses, and examining the relationship between sleep and lifestyle factors. Despite their potential, challenges like validation against polysomnography, regulatory hurdles, data privacy, and usability hinder clinical adoption. This review explores these devices, their applications, and integration challenges in clinical practice.
{"title":"EEG-based headset sleep wearable devices","authors":"Karmen Markov, Mohamed Elgendi, Carlo Menon","doi":"10.1038/s44328-024-00013-y","DOIUrl":"10.1038/s44328-024-00013-y","url":null,"abstract":"The rise of wearable technology has led to EEG-based sleep monitoring devices that use electrodes placed on the forehead, ear, or neck. These devices offer promising applications in clinical and healthy populations by comparing sleep patterns, monitoring intervention responses, and examining the relationship between sleep and lifestyle factors. Despite their potential, challenges like validation against polysomnography, regulatory hurdles, data privacy, and usability hinder clinical adoption. This review explores these devices, their applications, and integration challenges in clinical practice.","PeriodicalId":501705,"journal":{"name":"npj Biosensing","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44328-024-00013-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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