{"title":"AuxSynBio:了解和设计辅助素的合成生物学工具","authors":"","doi":"10.1016/j.copbio.2024.103194","DOIUrl":null,"url":null,"abstract":"<div><p>The plant hormone auxin is a crucial coordinator of nearly all plant growth and development processes. Because of its centrality to plant physiology and the modular nature of the signaling pathway, auxin has played a critical role at the forefront of plant synthetic biology. This review will highlight how auxin is both a subject and an object of synthetic biology. Engineering biology approaches are deepening our understanding of how auxin pathways are wired and tuned, particularly through the creative use of signaling pathway recapitulation in yeast and engineered orthogonal auxin-receptor pairs. Auxin biology has also been mined for parts by synthetic biologists, with components being used for inducible protein degradation systems (auxin-inducible degron), auxin biosensors, synthetic cell–cell communication, and plant engineering.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924001307/pdfft?md5=6774458c5a1f23b51d0cb75c92deb9b5&pid=1-s2.0-S0958166924001307-main.pdf","citationCount":"0","resultStr":"{\"title\":\"AuxSynBio: synthetic biology tools to understand and engineer auxin\",\"authors\":\"\",\"doi\":\"10.1016/j.copbio.2024.103194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The plant hormone auxin is a crucial coordinator of nearly all plant growth and development processes. Because of its centrality to plant physiology and the modular nature of the signaling pathway, auxin has played a critical role at the forefront of plant synthetic biology. This review will highlight how auxin is both a subject and an object of synthetic biology. Engineering biology approaches are deepening our understanding of how auxin pathways are wired and tuned, particularly through the creative use of signaling pathway recapitulation in yeast and engineered orthogonal auxin-receptor pairs. Auxin biology has also been mined for parts by synthetic biologists, with components being used for inducible protein degradation systems (auxin-inducible degron), auxin biosensors, synthetic cell–cell communication, and plant engineering.</p></div>\",\"PeriodicalId\":10833,\"journal\":{\"name\":\"Current opinion in biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.1000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0958166924001307/pdfft?md5=6774458c5a1f23b51d0cb75c92deb9b5&pid=1-s2.0-S0958166924001307-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0958166924001307\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0958166924001307","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
AuxSynBio: synthetic biology tools to understand and engineer auxin
The plant hormone auxin is a crucial coordinator of nearly all plant growth and development processes. Because of its centrality to plant physiology and the modular nature of the signaling pathway, auxin has played a critical role at the forefront of plant synthetic biology. This review will highlight how auxin is both a subject and an object of synthetic biology. Engineering biology approaches are deepening our understanding of how auxin pathways are wired and tuned, particularly through the creative use of signaling pathway recapitulation in yeast and engineered orthogonal auxin-receptor pairs. Auxin biology has also been mined for parts by synthetic biologists, with components being used for inducible protein degradation systems (auxin-inducible degron), auxin biosensors, synthetic cell–cell communication, and plant engineering.
期刊介绍:
Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time.
As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows.
COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.