在多通道阴道圆筒脉冲剂量率近距离放射治疗中使用无机闪烁探测器进行体内剂量测定：脉冲剂量率近距离放射治疗的剂量测定

IF 3.4 Q2 ONCOLOGY Physics and Imaging in Radiation Oncology Pub Date : 2024-08-25 DOI:10.1016/j.phro.2024.100638

Peter D. Georgi , Søren K. Nielsen , Anders T. Hansen , Harald Spejlborg , Susanne Rylander , Jacob Lindegaard , Simon Buus , Christian Wulff , Primoz Petric , Kari Tanderup , Jacob G. Johansen

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引用次数: 0

摘要

背景和目的体内剂量测定并非近距离放射治疗的标准，有些误差会被忽视。本研究旨在利用体内剂量测定评估多通道阴道圆筒脉冲剂量率近距离放射治疗的准确性。材料和方法在2019-2022年间收集了22名接受多通道圆筒脉冲剂量率近距离放射治疗的患者（32个分次）的体内剂量测定数据。无机闪烁探测器安装在圆柱体通道中。每个部分都作为独立的数据集进行分析。使用基于体内剂量测定的放射源跟踪来确定放射源到探测器的相对位置。将测量到的剂量与计划剂量和基于源追踪重新计算的剂量进行比较。假设在整个治疗过程中器官和涂抹器的几何形状没有变化，则通过γ指数分析和剂量-体积-柱状图对选定体积中的计划剂量和基于源追踪的剂量分布进行比较。在 31/32 个馏分中，偏差在体内剂量测定不确定性（平均 9.7%，k = 2）和计划剂量计算不确定性（1.6%，k = 2）的综合范围内。88%的通道的停留位置偏差为 2 毫米，最大为 5.1 毫米（不确定性为 4.0 毫米，k = 2）。3 %/2 mm γ 通过率平均为 97.0 %（临床目标容积 (CTV)）、100.0 %（直肠）和 99.9 %（膀胱）。CTV D98 的平均偏差（± SD）为-1.1 ± 2.9 %，膀胱和直肠 D2cm3 的平均偏差（± SD）分别为-0.2 ± 0.9 %和-1.2 ± 2.5 %，这表明预期剂量与输送剂量之间存在良好的一致性。

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In vivo dosimetry with an inorganic scintillation detector during multi-channel vaginal cylinder pulsed dose-rate brachytherapy: Dosimetry for pulsed dose-rate brachytherapy

Background and purpose

In vivo dosimetry is not standard in brachytherapy and some errors go undetected. The aim of this study was to evaluate the accuracy of multi-channel vaginal cylinder pulsed dose-rate brachytherapy using in vivo dosimetry.

Materials and methods

In vivo dosimetry data was collected during the years 2019–2022 for 22 patients (32 fractions) receiving multi-channel cylinder pulsed dose-rate brachytherapy. An inorganic scintillation detector was inserted in a cylinder channel. Each fraction was analysed as independent data sets. In vivo dosimetry-based source-tracking was used to determine the relative source-to-detector position. Measured dose was compared to planned and re-calculated source-tracking based doses. Assuming no change in organ and applicator geometry throughout treatment, the planned and source-tracking based dose distributions were compared in select volumes via γ-index analysis and dose-volume-histograms.

Results

The mean ± SD planned vs. measured dose deviations in the first pulse were 0.8 $\pm$ 5.9 %. In 31/32 fractions the deviation was within the combined in vivo dosimetry uncertainty (averaging 9.7 %, k = 2) and planning dose calculation uncertainty (1.6 %, k = 2). The dwell-position offsets were < 2 mm for 88 % of channels, with the largest being 5.1 mm (4.0 mm uncertainty, k = 2). 3 %/2 mm γ pass-rates averaged 97.0 % (clinical target volume (CTV)), 100.0 % (rectum), 99.9 % (bladder). The mean ± SD deviation was −1. $1$ ± 2.9 % for CTV D98, and −0.2 ± 0.9 % and −1.2 ± 2.5 %, for bladder and rectum D2cm³ respectively, indicating good agreement between intended and delivered dose.