{"title":"基于沸石咪唑框架的抗癌药物输送系统与表面电荷和路易斯碱配体的双重作用有关（Adv.）","authors":"Wenjuan Yang, Lingling Tian, Ning Zhao, Lingyan Feng, Bingpu Zhou, Yongheng Zhu, Xinghua Gao, Yuan Zhang","doi":"10.1002/adtp.202470017","DOIUrl":null,"url":null,"abstract":"<p>Zeolitic imidazolate frameworks (ZIFs) are emerging as a promising nanocarrier platform for drug delivery. In article 2300447, Yongheng Zhu, Xinghua Gao, Yuan Zhang, and co-workers elucidate the crucial role of surface charge and Lewis-base ligand in determining cytotoxicity, cellular uptake, and intracellular release. These findings offer valuable insights for the screening of ZIF-based nanocarriers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470017","citationCount":"0","resultStr":"{\"title\":\"Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand (Adv. Therap. 9/2024)\",\"authors\":\"Wenjuan Yang, Lingling Tian, Ning Zhao, Lingyan Feng, Bingpu Zhou, Yongheng Zhu, Xinghua Gao, Yuan Zhang\",\"doi\":\"10.1002/adtp.202470017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Zeolitic imidazolate frameworks (ZIFs) are emerging as a promising nanocarrier platform for drug delivery. In article 2300447, Yongheng Zhu, Xinghua Gao, Yuan Zhang, and co-workers elucidate the crucial role of surface charge and Lewis-base ligand in determining cytotoxicity, cellular uptake, and intracellular release. These findings offer valuable insights for the screening of ZIF-based nanocarriers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":7284,\"journal\":{\"name\":\"Advanced Therapeutics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470017\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Therapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adtp.202470017\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adtp.202470017","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
沸石咪唑啉框架（ZIFs）正在成为一种前景广阔的纳米载体药物递送平台。在第 2300447 号文章中，朱永恒、高兴华、张远及其合作者阐明了表面电荷和路易斯碱配体在决定细胞毒性、细胞摄取和细胞内释放方面的关键作用。这些发现为筛选基于 ZIF 的纳米载体提供了宝贵的见解。
Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand (Adv. Therap. 9/2024)
Zeolitic imidazolate frameworks (ZIFs) are emerging as a promising nanocarrier platform for drug delivery. In article 2300447, Yongheng Zhu, Xinghua Gao, Yuan Zhang, and co-workers elucidate the crucial role of surface charge and Lewis-base ligand in determining cytotoxicity, cellular uptake, and intracellular release. These findings offer valuable insights for the screening of ZIF-based nanocarriers.
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