高龄产妇对老年大鼠缺血性中风易感性的影响血脑屏障通透性和基因表达研究

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2024-01-01 DOI:10.1016/j.nbas.2024.100125
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引用次数: 0

摘要

背景高龄产妇(AMA),通常指 35 岁或 35 岁以上怀孕。根据证据,这一趋势引起了人们对母亲潜在健康后果的关注,尤其是与缺血性中风有关的健康后果。研究表明,AMA 可能与女性缺血性中风的风险较高有关,这是因为生理变化会影响血管健康并增加心血管风险因素。本研究的目的是调查 AMA 对老年大鼠缺血性中风后损伤程度的影响。方法分别对高龄(10 个月)和低龄(4 个月)分娩的雌性大鼠进行老年(20 个月)缺血性中风试验,然后进行比较。我们评估了缺血性脑卒中后的神经功能缺损、梗死体积、血脑屏障(BBB)通透性、TNF-α水平、总氧化能力以及在BBB完整性中发挥作用的基因表达(血管内皮生长因子、闭塞素和MMP-9)。此外,AMA 大鼠在经历缺血性中风后,TNF-α 和总氧化能力水平明显升高。讨论 与妊娠相关的生理变化、衰老、血管基因表达和炎症因子之间的复杂关系可能是导致高龄妊娠大鼠脆弱性增加的原因之一。妊娠相关改变与衰老之间的相似性突显了高龄孕妇对缺血性中风易感性的影响。
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Effect of advanced maternal age on ischemic stroke vulnerability in aged rats: Investigating on blood-brain barrier permeability and gene expression

Background

Advanced maternal age (AMA), commonly defined as pregnancy at or above 35 years old. Based on the evidence, this trend has raised concerns about potential health consequences for mothers, particularly in relation to ischemic stroke. Studies suggest that AMA may be associated with a higher risk of ischemic stroke in women due to physiological changes that impact vascular health and increase cardiovascular risk factors. The aim of this study was to investigate the effect of AMA on the extent of damage after ischemic stroke in aged rats.

Methods

Female rats that gave birth at an old age (10 months) and at a young age (4 months) were subjected to ischemic stroke in old age (20 months) and subsequently compared.

We assessed neurological deficits, infarct volume, blood–brain barrier (BBB) permeability, TNF-alpha levels, total oxidant capacity, and gene expressions that play a role in BBB integrity (VEGF, Occludin, and MMP-9) following ischemic stroke.

Results

There were significantly elevated levels of MMP-9 expression and reduced levels of occludin in AMA rats. Additionally, AMA rats had significantly higher levels of TNF-alpha and total oxidant capacity after experiencing an ischemic stroke. AMA rats showed significantly higher brain water content (BBB permeability), infarct volume, and neurological deficits compared to young-aged pregnancies.

Discussion

Complex relationship between pregnancy-related physiological changes, aging, vascular gene expression, and inflammatory factors may play a role in the increased vulnerability observed in older pregnant rats. The similarities between pregnancy-related alterations and aging highlight the influence of advanced maternal age on susceptibility to ischemic stroke.

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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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