产前和生命早期接触细颗粒物与幼儿期端粒长度的关系

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-09-11 DOI:10.1016/j.ijheh.2024.114447
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引用次数: 0

摘要

背景端粒长度是分子衰老的生物标志物,可能会受到从子宫内开始的空气污染暴露的影响。我们旨在研究产前和生命早期暴露于细颗粒物(PM2.5)与儿童白细胞端粒长度(LTL)之间的关系,并探讨性别差异。使用基于卫星的时空分辨预测模型估算了住宅水平的 PM2.5 暴露情况。使用定量实时聚合酶链反应法测量了从 4-6 岁时采集的血液中分离的 DNA 中的平均相对低密度脂蛋白。线性回归模型用于检验整个孕期、各个孕期、产后第一年的平均PM2.5与LTL之间的关系。模型根据母亲年龄和入学时的受教育程度、产前环境烟草烟雾暴露、儿童性别、年龄以及LTL测量时的体重指数z-分数进行了调整。结果在特定孕期模型中,我们发现孕期后三个月的 PM2.5 与 LTL 延长之间存在关联(β:4.34,95%CI [0.42,8.42],每增加 5 μg/m3)。性别对怀孕后三个月 PM2.5 平均值的影响具有提示性,每增加 5 微克/立方米,女性与男性的关联性更强(β:7.12 [95%CI: 0.98, 13.6] 和 β:1.43 [95%CI: -3.46, 6.57])。了解PM2.5暴露的时间和性别差异可能有助于了解生命早期端粒的动态变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prenatal and early life exposure to fine particulate matter and telomere length in early childhood

Background

Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM2.5) and leukocyte telomere length (LTL) in children and explore sex differences.

Methods

Analyses included 384 mother–child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City. Exposure to PM2.5 was estimated at the residential level using a satellite based spatio-temporally resolved prediction model. Average relative LTL was measured in DNA isolated from blood collected at age 4–6 years using quantitative real-time polymerase chain reaction. Linear regression models were used to examine the association between average PM2.5 across pregnancy, individual trimesters, first postnatal year, and LTL. Models were adjusted for maternal age and education at enrollment, prenatal environmental tobacco smoke exposure, child sex, age, and body mass index z-score at LTL measurement. Effect modification by sex was investigated with interaction terms and stratification.

Results

In trimester specific models, we found an association between 2nd trimester PM2.5 and elongated LTL (β: 4.34, 95%CI [0.42, 8.42], per 5 μg/m3 increase). There was suggestive effect modification by sex on average 2nd trimester PM2.5 with stronger associations seen in females compared to males (β: 7.12, [95%CI: 0.98, 13.6] and β: 1.43 [95%CI: −3.46, 6.57]) per 5 μg/m3 increase respectively.

Conclusion

Second trimester PM2.5 levels were associated with changes in LTL in early childhood. Understanding temporal and sex differences in PM2.5 exposure may provide insights into telomere dynamics over early life.

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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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