Jesephat Edzie , Cecilia Alcala , Tessa R. Bloomquist , Ivan Gutierrez-Avila , Allan C. Just , Vishal Midya , Martha María Téllez Rojo , Guadalupe Estrada-Gutierrez , Rosalind J. Wright , Robert O. Wright , Andrea A. Baccarelli , Maria José Rosa
{"title":"产前和生命早期接触细颗粒物与幼儿期端粒长度的关系","authors":"Jesephat Edzie , Cecilia Alcala , Tessa R. Bloomquist , Ivan Gutierrez-Avila , Allan C. Just , Vishal Midya , Martha María Téllez Rojo , Guadalupe Estrada-Gutierrez , Rosalind J. Wright , Robert O. Wright , Andrea A. Baccarelli , Maria José Rosa","doi":"10.1016/j.ijheh.2024.114447","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM<sub>2.5</sub>) and leukocyte telomere length (LTL) in children and explore sex differences.</p></div><div><h3>Methods</h3><p>Analyses included 384 mother–child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City. Exposure to PM<sub>2.5</sub> was estimated at the residential level using a satellite based spatio-temporally resolved prediction model. Average relative LTL was measured in DNA isolated from blood collected at age 4–6 years using quantitative real-time polymerase chain reaction. Linear regression models were used to examine the association between average PM<sub>2.5</sub> across pregnancy, individual trimesters, first postnatal year, and LTL. Models were adjusted for maternal age and education at enrollment, prenatal environmental tobacco smoke exposure, child sex, age, and body mass index z-score at LTL measurement. Effect modification by sex was investigated with interaction terms and stratification.</p></div><div><h3>Results</h3><p>In trimester specific models, we found an association between 2nd trimester PM<sub>2.5</sub> and elongated LTL (β: 4.34, 95%CI [0.42, 8.42], per 5 μg/m<sup>3</sup> increase). There was suggestive effect modification by sex on average 2nd trimester PM<sub>2.5</sub> with stronger associations seen in females compared to males (β: 7.12, [95%CI: 0.98, 13.6] and β: 1.43 [95%CI: −3.46, 6.57]) per 5 μg/m<sup>3</sup> increase respectively.</p></div><div><h3>Conclusion</h3><p>Second trimester PM<sub>2.5</sub> levels were associated with changes in LTL in early childhood. Understanding temporal and sex differences in PM<sub>2.5</sub> exposure may provide insights into telomere dynamics over early life.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114447"},"PeriodicalIF":4.5000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prenatal and early life exposure to fine particulate matter and telomere length in early childhood\",\"authors\":\"Jesephat Edzie , Cecilia Alcala , Tessa R. Bloomquist , Ivan Gutierrez-Avila , Allan C. Just , Vishal Midya , Martha María Téllez Rojo , Guadalupe Estrada-Gutierrez , Rosalind J. Wright , Robert O. Wright , Andrea A. Baccarelli , Maria José Rosa\",\"doi\":\"10.1016/j.ijheh.2024.114447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM<sub>2.5</sub>) and leukocyte telomere length (LTL) in children and explore sex differences.</p></div><div><h3>Methods</h3><p>Analyses included 384 mother–child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City. Exposure to PM<sub>2.5</sub> was estimated at the residential level using a satellite based spatio-temporally resolved prediction model. Average relative LTL was measured in DNA isolated from blood collected at age 4–6 years using quantitative real-time polymerase chain reaction. Linear regression models were used to examine the association between average PM<sub>2.5</sub> across pregnancy, individual trimesters, first postnatal year, and LTL. Models were adjusted for maternal age and education at enrollment, prenatal environmental tobacco smoke exposure, child sex, age, and body mass index z-score at LTL measurement. Effect modification by sex was investigated with interaction terms and stratification.</p></div><div><h3>Results</h3><p>In trimester specific models, we found an association between 2nd trimester PM<sub>2.5</sub> and elongated LTL (β: 4.34, 95%CI [0.42, 8.42], per 5 μg/m<sup>3</sup> increase). There was suggestive effect modification by sex on average 2nd trimester PM<sub>2.5</sub> with stronger associations seen in females compared to males (β: 7.12, [95%CI: 0.98, 13.6] and β: 1.43 [95%CI: −3.46, 6.57]) per 5 μg/m<sup>3</sup> increase respectively.</p></div><div><h3>Conclusion</h3><p>Second trimester PM<sub>2.5</sub> levels were associated with changes in LTL in early childhood. Understanding temporal and sex differences in PM<sub>2.5</sub> exposure may provide insights into telomere dynamics over early life.</p></div>\",\"PeriodicalId\":13994,\"journal\":{\"name\":\"International journal of hygiene and environmental health\",\"volume\":\"263 \",\"pages\":\"Article 114447\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of hygiene and environmental health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1438463924001287\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hygiene and environmental health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1438463924001287","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Prenatal and early life exposure to fine particulate matter and telomere length in early childhood
Background
Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM2.5) and leukocyte telomere length (LTL) in children and explore sex differences.
Methods
Analyses included 384 mother–child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City. Exposure to PM2.5 was estimated at the residential level using a satellite based spatio-temporally resolved prediction model. Average relative LTL was measured in DNA isolated from blood collected at age 4–6 years using quantitative real-time polymerase chain reaction. Linear regression models were used to examine the association between average PM2.5 across pregnancy, individual trimesters, first postnatal year, and LTL. Models were adjusted for maternal age and education at enrollment, prenatal environmental tobacco smoke exposure, child sex, age, and body mass index z-score at LTL measurement. Effect modification by sex was investigated with interaction terms and stratification.
Results
In trimester specific models, we found an association between 2nd trimester PM2.5 and elongated LTL (β: 4.34, 95%CI [0.42, 8.42], per 5 μg/m3 increase). There was suggestive effect modification by sex on average 2nd trimester PM2.5 with stronger associations seen in females compared to males (β: 7.12, [95%CI: 0.98, 13.6] and β: 1.43 [95%CI: −3.46, 6.57]) per 5 μg/m3 increase respectively.
Conclusion
Second trimester PM2.5 levels were associated with changes in LTL in early childhood. Understanding temporal and sex differences in PM2.5 exposure may provide insights into telomere dynamics over early life.
期刊介绍:
The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.