{"title":"柑橘皮中的西奈素通过调节小鼠肠道微生物群和血清代谢来缓解 DSS 诱导的炎症","authors":"Zuomin Hu, Zhongxing Chu, Xuke Ling, Yuchi Wu, Dandan Qin, Feiyan Yang, Xudong Yu, Yaping Zhou, Yiping Tang, Feijun Luo","doi":"10.1016/j.fbio.2024.105066","DOIUrl":null,"url":null,"abstract":"<div><p>Sinensetin is a polymethoxylated flavone, which is considered to be an important functional composition in citrus peels. In this study, the anti-inflammatory effect and potential mechanism of sinensetin were evaluated by multi-omics analysis in the dextran sulfate sodium (DSS)-induced colitis model. The results showed that sinensetin significantly inhibited inflammation and alleviated gut microbiota imbalance in the DSS-induced mice. Sinensetin supplementation increased the abundance of <em>Faecalibaculum</em>, <em>Colidextribacter</em>, <em>Lachnospiraceae_NK4A136_group</em>, <em>norank_f_norank_Clostridia_UCG-014</em> and <em>Christensenella</em>, reduced abundance of <em>Bacteroides</em>, <em>Escherichia-Shigella</em>, <em>Parasutterella</em> and <em>Clostridium_sensu_stricto_1</em>. The metabolome of serum samples showed 117 differential metabolites were significantly altered by sinensetin supplementation in colitis mice, and 24 of these metabolites were involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway. KEGG predictions based on both gut microbiota and serum metabolites suggested that cysteine and methionine metabolism are mainly affected by sinensetin supplementation. These results indicate that sinensetin inhibit DSS-induced colitis by modulating gut microbiota and ameliorating serum metabolism.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice\",\"authors\":\"Zuomin Hu, Zhongxing Chu, Xuke Ling, Yuchi Wu, Dandan Qin, Feiyan Yang, Xudong Yu, Yaping Zhou, Yiping Tang, Feijun Luo\",\"doi\":\"10.1016/j.fbio.2024.105066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Sinensetin is a polymethoxylated flavone, which is considered to be an important functional composition in citrus peels. In this study, the anti-inflammatory effect and potential mechanism of sinensetin were evaluated by multi-omics analysis in the dextran sulfate sodium (DSS)-induced colitis model. The results showed that sinensetin significantly inhibited inflammation and alleviated gut microbiota imbalance in the DSS-induced mice. Sinensetin supplementation increased the abundance of <em>Faecalibaculum</em>, <em>Colidextribacter</em>, <em>Lachnospiraceae_NK4A136_group</em>, <em>norank_f_norank_Clostridia_UCG-014</em> and <em>Christensenella</em>, reduced abundance of <em>Bacteroides</em>, <em>Escherichia-Shigella</em>, <em>Parasutterella</em> and <em>Clostridium_sensu_stricto_1</em>. The metabolome of serum samples showed 117 differential metabolites were significantly altered by sinensetin supplementation in colitis mice, and 24 of these metabolites were involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway. KEGG predictions based on both gut microbiota and serum metabolites suggested that cysteine and methionine metabolism are mainly affected by sinensetin supplementation. These results indicate that sinensetin inhibit DSS-induced colitis by modulating gut microbiota and ameliorating serum metabolism.</p></div>\",\"PeriodicalId\":12409,\"journal\":{\"name\":\"Food Bioscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212429224014962\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Bioscience","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212429224014962","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice
Sinensetin is a polymethoxylated flavone, which is considered to be an important functional composition in citrus peels. In this study, the anti-inflammatory effect and potential mechanism of sinensetin were evaluated by multi-omics analysis in the dextran sulfate sodium (DSS)-induced colitis model. The results showed that sinensetin significantly inhibited inflammation and alleviated gut microbiota imbalance in the DSS-induced mice. Sinensetin supplementation increased the abundance of Faecalibaculum, Colidextribacter, Lachnospiraceae_NK4A136_group, norank_f_norank_Clostridia_UCG-014 and Christensenella, reduced abundance of Bacteroides, Escherichia-Shigella, Parasutterella and Clostridium_sensu_stricto_1. The metabolome of serum samples showed 117 differential metabolites were significantly altered by sinensetin supplementation in colitis mice, and 24 of these metabolites were involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway. KEGG predictions based on both gut microbiota and serum metabolites suggested that cysteine and methionine metabolism are mainly affected by sinensetin supplementation. These results indicate that sinensetin inhibit DSS-induced colitis by modulating gut microbiota and ameliorating serum metabolism.
Food BioscienceBiochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍:
Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.