产前接触全氟烷基和多氟烷基物质与儿童骨矿物质密度:一项前瞻性出生队列研究

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-09-12 DOI:10.1016/j.ijheh.2024.114459
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引用次数: 0

摘要

背景和目的全氟烷基和多氟烷基物质(PFAS)已被证明对骨骼发育具有潜在毒性。然而,在流行病学研究中,产前接触 PFAS 与后代骨骼健康之间的关系仍不清楚。因此,我们旨在研究产前暴露于 PFAS 是否与后代的骨矿物质密度(BMD)有关。采用液相色谱-质谱法(LC-MS)测定了脐带血浆中的 10 种 PFAS。采用多变量线性回归模型来估计单个 PFAS 浓度(作为连续变量或分为四分位)与儿童 BMD 之间的关系。结果在 10 种 PFAS 中,8 种的检出率为 90%,被纳入后续分析。在多变量线性回归模型中,我们观察到单个 PFAS(作为连续变量)与 8 岁儿童脊柱 BMD 之间没有明显关联。与最低四分位数相比,全氟丁烷磺酸盐(PFBS)的第二和第四四分位数与第一腰椎较高的 BMD 相关。BKMR分析表明,PFAS混合物与儿童BMD之间没有关联。鉴于流行病学证据的不一致性,我们需要进一步的研究来证实其他研究的这些发现,或阐明 PFAS 对骨骼的潜在毒性影响。
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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood bone mineral density: A prospective birth cohort study

Background and aim

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have demonstrated potential toxicity in skeletal development. However, the relationship between prenatal PFAS exposure and offspring bone health remains unclear in epidemiological studies. Therefore, we aim to investigate whether prenatal exposure to PFAS is associated with bone mineral density (BMD) in offspring.

Method

This study population included 182 mother-child pairs in the Shanghai Obesity and Allergy Cohort, enrolled during 2012–2013. 10 PFAS were measured by liquid chromatography-mass spectrometry (LC-MS) in cord plasma. The child's spinal BMD was measured using a dual-energy X-ray absorptiometry (DXA) scanner at the age of 8. Multivariable linear regression models were used to estimate the associations between individual PFAS concentrations (as a continuous variable or categorized into quartiles) and child BMD. Bayesian kernel machine regression (BKMR) was employed to explore the joint effects of PFAS mixtures on BMD.

Results

Among the 10 PFAS, 8 of them had a detection rate >90% and were included in the subsequent analysis. We observed no significant associations between individual PFAS (as a continuous variable) and spinal BMD in 8-year-old children using the multivariable linear regression model. When treated as quartile categories, the second and fourth quartiles of perfluorobutane sulfonate (PFBS) was associated with higher BMD in the first lumbar vertebra, compared with the lowest quartile. BKMR analysis revealed no association between the PFAS mixture and child BMD.

Conclusion

We observed no associations of prenatal PFAS exposure with child BMD at 8 years of age. Given the inconsistent epidemiological evidence, further research is needed to confirm these findings from other studies or elucidate the potentially toxic effects of PFAS on bone.

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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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