{"title":"在柔性 PMMA 芯片上原位自还原制备 Ti3C2Tx/Ag,用于定量检测 SARS-CoV-2","authors":"","doi":"10.1016/j.snb.2024.136610","DOIUrl":null,"url":null,"abstract":"<div><p>Surface enhanced Raman scattering (SERS) has proven to be of great superiority in the assay and prevention of infectious disease attributed to its rapid and specific fingerprint recognition ability toward trace molecules. However, it is still crucial to develop portable and precise chip for the reliable realization of on–site and large–scale screening. Here, a robust in–situ reduction strategy was employed to prepare Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub>@Ag nanocomposites, which was installed on a polymethyl methacrylate (PMMA) matrix to construct a novel flexible SERS chip with self–rectification capability. The resulting Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub>@Ag nanocomposites exhibited both electromagnetic and chemical enhancement effects, enabling high SERS activity. In particular, the as–developed SERS chip demonstrated fascinating signal reproducibility and quantitative detection capability by conducting the intrinsic Raman signal of PMMA as an internal standard. Furthermore, the PMMA–Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>@Ag chip facilitated the visualization of severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) nucleocapsid (N) with ultra–low limit of detection, stressing the potential application of this smart self–rectification SERS chip with high activity in real time and rapid monitoring of sudden infectious diseases.</p></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In–situ self–reduction preparation of Ti3C2Tx/Ag on flexible PMMA chip for quantitative detection of SARS–CoV–2\",\"authors\":\"\",\"doi\":\"10.1016/j.snb.2024.136610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Surface enhanced Raman scattering (SERS) has proven to be of great superiority in the assay and prevention of infectious disease attributed to its rapid and specific fingerprint recognition ability toward trace molecules. However, it is still crucial to develop portable and precise chip for the reliable realization of on–site and large–scale screening. Here, a robust in–situ reduction strategy was employed to prepare Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub>@Ag nanocomposites, which was installed on a polymethyl methacrylate (PMMA) matrix to construct a novel flexible SERS chip with self–rectification capability. The resulting Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub>@Ag nanocomposites exhibited both electromagnetic and chemical enhancement effects, enabling high SERS activity. In particular, the as–developed SERS chip demonstrated fascinating signal reproducibility and quantitative detection capability by conducting the intrinsic Raman signal of PMMA as an internal standard. Furthermore, the PMMA–Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>@Ag chip facilitated the visualization of severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) nucleocapsid (N) with ultra–low limit of detection, stressing the potential application of this smart self–rectification SERS chip with high activity in real time and rapid monitoring of sudden infectious diseases.</p></div>\",\"PeriodicalId\":425,\"journal\":{\"name\":\"Sensors and Actuators B: Chemical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.0000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensors and Actuators B: Chemical\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0925400524013406\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensors and Actuators B: Chemical","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925400524013406","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
In–situ self–reduction preparation of Ti3C2Tx/Ag on flexible PMMA chip for quantitative detection of SARS–CoV–2
Surface enhanced Raman scattering (SERS) has proven to be of great superiority in the assay and prevention of infectious disease attributed to its rapid and specific fingerprint recognition ability toward trace molecules. However, it is still crucial to develop portable and precise chip for the reliable realization of on–site and large–scale screening. Here, a robust in–situ reduction strategy was employed to prepare Ti3C2Tx@Ag nanocomposites, which was installed on a polymethyl methacrylate (PMMA) matrix to construct a novel flexible SERS chip with self–rectification capability. The resulting Ti3C2Tx@Ag nanocomposites exhibited both electromagnetic and chemical enhancement effects, enabling high SERS activity. In particular, the as–developed SERS chip demonstrated fascinating signal reproducibility and quantitative detection capability by conducting the intrinsic Raman signal of PMMA as an internal standard. Furthermore, the PMMA–Ti3C2Tx@Ag chip facilitated the visualization of severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) nucleocapsid (N) with ultra–low limit of detection, stressing the potential application of this smart self–rectification SERS chip with high activity in real time and rapid monitoring of sudden infectious diseases.
期刊介绍:
Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.