聚合诱导发射的近红外 (NIR)-II 共轭聚合物与非共轭段耦合,用于 NIR-II 荧光成像引导的 NIR-II 光热疗法

IF 2.5 4区 化学 Q3 POLYMER SCIENCE Macromolecular Chemistry and Physics Pub Date : 2024-08-29 DOI:10.1002/macp.202400268
Zixin Hu, Jiarong He, Chenhang Xi, Sicheng Xu, Qingming Shen, Pengfei Chen, Pengfei Sun, Quli Fan
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引用次数: 0

摘要

开发基于共轭聚合物的水溶性纳米粒子,用于近红外-II(NIR-II)荧光(FL;1000-1700 纳米)引导的光热疗法,有望推动癌症治疗。然而,过度的非辐射衰变会导致共轭聚合物的荧光几乎完全熄灭。因此,如何在抑制非辐射衰变的同时保持高质量的荧光成像和出色的光热转换效率是一项严峻的挑战。本研究利用 Stille 偶联反应设计并合成了一系列具有聚集诱导发射(AIE)效应的 NIR-II 共轭聚合物。通过调节 AIE 单元和在聚合物骨架中引入非共轭骨架的双重增强策略,得到了αAIE 值高达 3.27 的 BCT1。BCT1 纳米粒子具有优异的近红外-II 荧光性能,光热转换效率高达 70.51%,与 BT1 相比,荧光增强了 10 倍。体外和体内实验均验证了其良好的生物相容性和在近红外-II荧光成像中的出色表现,可用于准确确定肿瘤位置。这项研究为设计和开发用于近红外-II 荧光成像引导的光热疗法的多功能共轭聚合物提供了一种新的策略和方法。
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Aggregation-Induced Emission Near-Infrared (NIR)-II-Conjugated Polymers Coupled With Nonconjugated Segments for NIR-II Fluorescence Imaging–Guided NIR-II Photothermal Therapy

The development of conjugated polymer–based water-soluble nanoparticles for near-infrared-II (NIR-II) fluorescence (FL; 1000–1700 nm)-guided photothermal therapy holds promise in advancing cancer treatment. However, excessive nonradiative decay leads to almost complete quenching of conjugated polymers’ fluorescence. Therefore, a critical challenge is to suppress nonradiative decay while maintaining high-quality fluorescence imaging and excellent photothermal conversion efficiency. In this study, a series of NIR-II-conjugated polymers with aggregation-induced emission (AIE) effects are designed and synthesized using the Stille coupling reaction. The dual enhancement strategy of modulating the AIE units and introducing non-conjugated backbone into the polymer backbone resulted in BCT1 with a high αAIE value of 3.27. BCT1 nanoparticles exhibit excellent NIR-II fluorescence, a high photothermal conversion efficiency of 70.51%, and a tenfold enhancement in fluorescence compared with BT1. Both in vitro and in vivo experiments validated their good biocompatibility and outstanding performance in NIR-II fluorescence imaging for accurately determining the location of tumors. This study provides a novel strategy and method for designing and developing multifunctional conjugated polymers for NIR-II fluorescence imaging–guided photothermal therapy.

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来源期刊
Macromolecular Chemistry and Physics
Macromolecular Chemistry and Physics 化学-高分子科学
CiteScore
4.30
自引率
4.00%
发文量
278
审稿时长
1.4 months
期刊介绍: Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.
期刊最新文献
Issue Information: Macromol. Chem. Phys. 3/2025 Front Cover: Macromol. Chem. Phys. 3/2025 Front Cover: Macromol. Chem. Phys. 2/2025 Issue Information: Macromol. Chem. Phys. 2/2025 Issue Information: Macromol. Chem. Phys. 1/2025
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