{"title":"聚合诱导发射的近红外 (NIR)-II 共轭聚合物与非共轭段耦合,用于 NIR-II 荧光成像引导的 NIR-II 光热疗法","authors":"Zixin Hu, Jiarong He, Chenhang Xi, Sicheng Xu, Qingming Shen, Pengfei Chen, Pengfei Sun, Quli Fan","doi":"10.1002/macp.202400268","DOIUrl":null,"url":null,"abstract":"<p>The development of conjugated polymer–based water-soluble nanoparticles for near-infrared-II (NIR-II) fluorescence (FL; 1000–1700 nm)-guided photothermal therapy holds promise in advancing cancer treatment. However, excessive nonradiative decay leads to almost complete quenching of conjugated polymers’ fluorescence. Therefore, a critical challenge is to suppress nonradiative decay while maintaining high-quality fluorescence imaging and excellent photothermal conversion efficiency. In this study, a series of NIR-II-conjugated polymers with aggregation-induced emission (AIE) effects are designed and synthesized using the Stille coupling reaction. The dual enhancement strategy of modulating the AIE units and introducing non-conjugated backbone into the polymer backbone resulted in BCT1 with a high αAIE value of 3.27. BCT1 nanoparticles exhibit excellent NIR-II fluorescence, a high photothermal conversion efficiency of 70.51%, and a tenfold enhancement in fluorescence compared with BT1. Both in vitro and in vivo experiments validated their good biocompatibility and outstanding performance in NIR-II fluorescence imaging for accurately determining the location of tumors. This study provides a novel strategy and method for designing and developing multifunctional conjugated polymers for NIR-II fluorescence imaging–guided photothermal therapy.</p>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"225 24","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aggregation-Induced Emission Near-Infrared (NIR)-II-Conjugated Polymers Coupled With Nonconjugated Segments for NIR-II Fluorescence Imaging–Guided NIR-II Photothermal Therapy\",\"authors\":\"Zixin Hu, Jiarong He, Chenhang Xi, Sicheng Xu, Qingming Shen, Pengfei Chen, Pengfei Sun, Quli Fan\",\"doi\":\"10.1002/macp.202400268\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The development of conjugated polymer–based water-soluble nanoparticles for near-infrared-II (NIR-II) fluorescence (FL; 1000–1700 nm)-guided photothermal therapy holds promise in advancing cancer treatment. However, excessive nonradiative decay leads to almost complete quenching of conjugated polymers’ fluorescence. Therefore, a critical challenge is to suppress nonradiative decay while maintaining high-quality fluorescence imaging and excellent photothermal conversion efficiency. In this study, a series of NIR-II-conjugated polymers with aggregation-induced emission (AIE) effects are designed and synthesized using the Stille coupling reaction. The dual enhancement strategy of modulating the AIE units and introducing non-conjugated backbone into the polymer backbone resulted in BCT1 with a high αAIE value of 3.27. BCT1 nanoparticles exhibit excellent NIR-II fluorescence, a high photothermal conversion efficiency of 70.51%, and a tenfold enhancement in fluorescence compared with BT1. Both in vitro and in vivo experiments validated their good biocompatibility and outstanding performance in NIR-II fluorescence imaging for accurately determining the location of tumors. This study provides a novel strategy and method for designing and developing multifunctional conjugated polymers for NIR-II fluorescence imaging–guided photothermal therapy.</p>\",\"PeriodicalId\":18054,\"journal\":{\"name\":\"Macromolecular Chemistry and Physics\",\"volume\":\"225 24\",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular Chemistry and Physics\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/macp.202400268\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Chemistry and Physics","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/macp.202400268","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Aggregation-Induced Emission Near-Infrared (NIR)-II-Conjugated Polymers Coupled With Nonconjugated Segments for NIR-II Fluorescence Imaging–Guided NIR-II Photothermal Therapy
The development of conjugated polymer–based water-soluble nanoparticles for near-infrared-II (NIR-II) fluorescence (FL; 1000–1700 nm)-guided photothermal therapy holds promise in advancing cancer treatment. However, excessive nonradiative decay leads to almost complete quenching of conjugated polymers’ fluorescence. Therefore, a critical challenge is to suppress nonradiative decay while maintaining high-quality fluorescence imaging and excellent photothermal conversion efficiency. In this study, a series of NIR-II-conjugated polymers with aggregation-induced emission (AIE) effects are designed and synthesized using the Stille coupling reaction. The dual enhancement strategy of modulating the AIE units and introducing non-conjugated backbone into the polymer backbone resulted in BCT1 with a high αAIE value of 3.27. BCT1 nanoparticles exhibit excellent NIR-II fluorescence, a high photothermal conversion efficiency of 70.51%, and a tenfold enhancement in fluorescence compared with BT1. Both in vitro and in vivo experiments validated their good biocompatibility and outstanding performance in NIR-II fluorescence imaging for accurately determining the location of tumors. This study provides a novel strategy and method for designing and developing multifunctional conjugated polymers for NIR-II fluorescence imaging–guided photothermal therapy.
期刊介绍:
Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.