利用基于 ARM 的微控制器开发基于阻抗光谱生物传感的便携式电化学传感平台

IF 3.5 Q2 CHEMISTRY, ANALYTICAL Sensors & diagnostics Pub Date : 2024-08-24 DOI:10.1039/D4SD00234B
Joseph Charles Khavul Spiro, Kundan Kumar Mishra, Vikram Narayanan Dhamu, Avi Bhatia, Sriram Muthukumar and Shalini Prasad
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引用次数: 0

摘要

由于阿特拉津等农药与多种食源性疾病有关,因此检测这类农药是一项重大的全球健康挑战。传统的检测方法往往缺乏灵敏度和时间效率,因此迫切需要改进早期检测技术,以减少农药污染和疫情爆发。本研究介绍了一种新型便携式电化学原型,它将基于 ARM 的微控制器与基于阻抗光谱(EIS)的生物传感系统集成在一起。通过算法处理的数据可生成易于解释的阻抗值。该平台对阿特拉津的检测范围很广(1 fg mL-1 至 10 ng mL-1),检测限(LoD)为 1 fg mL-1,检测处理时间约为 5 分钟,显示了其卓越的效率。该传感器的交叉反应变异始终保持在 20% 以下,确保了可靠的性能。这项研究旨在为生物传感应用提供一个低成本、可复制的移动平台,从而为实验室研究经验有限的人员提供更多机会,并扩大农药主动监测的范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Development of a portable electrochemical sensing platform for impedance spectroscopy-based biosensing using an ARM-based microcontroller†

Detecting pesticides like atrazine is a significant global health challenge due to their association with numerous foodborne illnesses. Traditional detection methods often lack sensitivity and time efficiency, highlighting the urgent need for improved early detection techniques to mitigate pesticide contamination and outbreaks. This study introduces a novel portable electrochemical prototype that integrates an ARM-based microcontroller with an impedance spectroscopy (EIS)-based biosensing system. The data processed through the algorithm generates easily interpretable impedance values. The platform demonstrates a broad detection range for atrazine (1 fg mL−1 to 10 ng mL−1) with a limit of detection (LoD) of 1 fg mL−1 and an assay processing time of approximately 5 minutes, showcasing its remarkable efficiency. The sensor consistently maintains cross-reactivity variation below 20%, ensuring reliable performance. This research aims to offer a low-cost, replicable mobile platform for biosensing applications, thereby enhancing access for individuals with limited lab-based research experience and broadening the scope of proactive pesticide monitoring.

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Back cover Pursuing theranostics: a multimodal architecture approach. A review on Ti3C2Tx based nanocomposites for the electrochemical sensing of clinically relevant biomarkers Back cover Introduction to Supramolecular Sensors: From Molecules to Materials
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