Sirt1/Nrf2通路是化疗诱发心脏毒性药物治疗的关键因素：微型综述

IF 2.8 4区医学 Q2 ONCOLOGY Medical Oncology Pub Date : 2024-09-11 DOI:10.1007/s12032-024-02494-3

Suleiman Ibrahim Shelash Mohammad, Asokan Vasudevan, Felix Oghenemaro Enwa, Jaya Bansal, Mamata Chahar, Mamdouh Eldesoqui, Muhammad Ikram Ullah, Zhanna R. Gardanova, Hanen Mahmod Hulail, Ahmed Hussein Zwamel

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引用次数: 0

摘要

化疗药物大大提高了癌症患者的生存几率。然而，这些抗肿瘤药物也可能对心血管系统产生不利影响，从而导致突然或逐渐的心力衰竭。自由基的产生导致氧化应激似乎是化疗诱发心脏毒性（CIC）的关键机制。有报告显示，Sirtuin-1（Sirt1）/核因子 E2 相关因子 2（Nrf2）信号通路被认为是通过抑制氧化应激、炎症和细胞凋亡来对抗心脏毒性的另一条途径。本综述总结了有关 CIC 的最新知识，并特别关注 Sirt1/Nrf2 通路的抗氧化调节特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review

The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these antitumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradual cardiac failure. The production of free radicals that result in oxidative stress appears to be the key mechanism by which chemotherapy-induced cardiotoxicity (CIC) happens. Reports suggest that the Sirtuin-1 (Sirt1)/Nuclear factor E2-associated factor 2 (Nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. This review concludes recent knowledge about CIC with a special focus on the anti-oxidative regulation properties of the Sirt1/Nrf2 pathway.

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.

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