Konatham Teja Kumar Reddy, Kamsali Rakesh, Segu Prathyusha, Jeetendra Kumar Gupta, Kasturi Nagasree, R. Lokeshvar, Selvaraja Elumalai, P. Dharani Prasad, Deepti Kolli
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引用次数: 0
摘要
糖尿病是一种以高血糖为特征的新陈代谢疾病。人们已经对微藻、细菌、海草、大型藻类、珊瑚和海绵等水产品的潜在抗糖尿病特性进行了研究。我们研究了在海洋资源中发现的多酚、肽、色素和固醇以及其他生物活性物质,看看它们是否有助于治疗或控制糖尿病,此外还介绍了改变糖尿病及其影响的几种治疗策略,如抑制蛋白酪氨酸磷酸酶 1B (PTP1B)、α-葡萄糖苷酶、α-淀粉酶、二肽基肽酶 IV (DPP-IV)、醛糖还原酶、脂肪酶、糖原合成酶激酶 3β (GSK-3β),以及预防胰岛素抵抗、促进肝脏抗氧化能力、刺激自然杀伤细胞、抗炎作用、增加 AMPK 磷酸化和糖及脂质代谢、减少氧化应激和预防 β-胰腺细胞。这项研究凸显了海洋生物活性化合物和微生物在改变糖尿病护理方面的革命性潜力。我们相信,在未来,创新、可持续和高效的治疗方法将通过开辟一条新的治疗道路,利用世界海洋的力量以及人类与海洋生态系统之间的共生关系,改善糖尿病患者的生活质量和治疗效果。这一研究领域为改变糖尿病护理提供了乐观和充满希望的机会。
Revolutionizing Diabetes Care: The Role of Marine Bioactive Compounds and Microorganisms
Diabetes is a metabolic condition characterized by high blood glucose levels. Aquatic products like microalgae, bacteria, seagrasses, macroalgae, corals, and sponges have been investigated for potential anti-diabetic properties. We looked at polyphenols, peptides, pigments, and sterols, as well as other bioactive substances found in marine resources, to see if they could help treat or manage diabetes, in addition to describing the several treatment strategies that alter diabetes and its implications, such as inhibition of protein tyrosine phosphatases 1B (PTP1B), α-glucosidase, α-amylase, dipeptidyl peptidase IV (DPP-IV), aldose reductase, lipase, glycogen synthase kinase 3β (GSK-3β), and insulin resistance prevention, promotion of liver antioxidant capacity, natural killer cell stimulant, anti-inflammatory actions, increased AMP-activated protein kinase (AMPK) phosphorylation and sugar and metabolism of the lipid, reducing oxidative stress, and β-pancreatic cell prevention. This study highlights the revolutionary potential of marine bioactive compounds and microorganisms in transforming diabetes care. We believe in a future in which innovative, sustainable, and efficient therapeutic approaches will result in improved quality of life and better outcomes for people with diabetes mellitus by forging a new path for treatment, utilizing the power of the world’s oceans, and capitalizing on the symbiotic relationship between humans and the marine ecosystem. This study area offers optimism and promising opportunities for transforming diabetes care.
期刊介绍:
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.