N. V. Aleksandrova, E. B. Nikolaenkova, Yu. V. Gatilov, V. I. Mamatyuk, V. P. Krivopalov
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引用次数: 0
摘要
2-Azido-4-chloro-6-phenylpyrimidine-5-carbaldehyde 是通过 Vilsmeier-Haack 反应合成的。在二甲基亚砜中，它转化为 7-氧代-5-苯基-4,7-二氢四唑并[1,5-a]嘧啶-6-甲醛，然后经过异构化再生成 6-苯甲酰四唑并[1,5-a]嘧啶-7(4H)-酮。通过核磁共振光谱和 X 射线衍射确定了所获化合物的结构。
Synthesis of 2-azido-4-chloro-6-phenylpyrimidine-5-carbaldehyde and its transformations in DMSO
2-Azido-4-chloro-6-phenylpyrimidine-5-carbaldehyde was synthesized by the Vilsmeier–Haack reaction. In DMSO, it transforms into 7-oxo-5-phenyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carbaldehyde and then undergoes isomerization recyclization into 6-benzoyltetrazolo[1,5-a]pyrimidin-7(4H)-one. The structures of the obtained compounds were determined by NMR spectroscopy and X-ray diffraction.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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