结直肠癌淋巴结转移的生物标志物:最新进展

IF 3.5 3区 医学 Q2 ONCOLOGY Frontiers in Oncology Pub Date : 2024-09-12 DOI:10.3389/fonc.2024.1409627
Xiao Zhu, Shui-quan Lin, Jun Xie, Li-hui Wang, Li-juan Zhang, Ling-ling Xu, Jian-guang Xu, Yang-bo Lv
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引用次数: 0

摘要

结直肠癌(CRC)是全球癌症相关死亡的第二大原因,仅次于肺癌,也是继肺癌和乳腺癌之后第三大最常见的恶性肿瘤。结直肠癌(CRC)的主要致死原因是远处转移。在 CRC 的各种转移途径中,淋巴结转移占主导地位,是影响患者预后和治疗决策的关键因素。这一系列错综复杂的事件涉及多方面的分子机制,凸显了 CRC 淋巴结转移的复杂性。参与淋巴结转移的细胞因子或蛋白可能是最有希望用于临床的淋巴结转移标志物。在这篇综述中,我们将借鉴最新文献中的观点,巩固目前对结直肠癌(CRC)淋巴结转移的机制和病理生理学的理解。我们还概述了在理解 CRC 淋巴结转移的分子基础方面取得的最新进展,以及创新靶向疗法的潜力。这些进展有望通过应对淋巴结转移带来的挑战来改善 CRC 患者的预后。
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Biomarkers of lymph node metastasis in colorectal cancer: update
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, trailing only behind lung cancer, and stands as the third most prevalent malignant tumor, following lung and breast cancers. The primary cause of mortality in colorectal cancer (CRC) stems from distant metastasis. Among the various routes of metastasis in CRC, lymph node metastasis predominates, serving as a pivotal factor in both prognostication and treatment decisions for patients. This intricate cascade of events involves multifaceted molecular mechanisms, highlighting the complexity underlying lymph node metastasis in CRC. The cytokines or proteins involved in lymph node metastasis may represent the most promising lymph node metastasis markers for clinical use. In this review, we aim to consolidate the current understanding of the mechanisms and pathophysiology underlying lymph node metastasis in colorectal cancer (CRC), drawing upon insights from the most recent literatures. We also provide an overview of the latest advancements in comprehending the molecular underpinnings of lymph node metastasis in CRC, along with the potential of innovative targeted therapies. These advancements hold promise for enhancing the prognosis of CRC patients by addressing the challenges posed by lymph node metastasis.
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来源期刊
Frontiers in Oncology
Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
6.20
自引率
10.60%
发文量
6641
审稿时长
14 weeks
期刊介绍: Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.
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