Jian Yang, Yong Wu, Yanyin Zhang, Xiang Peng, Chengzhi Jiang, Wanjing Zhou, Jiashun Dai, Aimin Xie, Hui Ye, Kai Zheng
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We recorded the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 and [<jats:sup>18</jats:sup>F]FDG PET/CT for detecting local recurrence, lymph node metastasis and distant metastasis. The SUVmax and background ratio (TBR) of local recurrence and metastases between [<jats:sup>18</jats:sup>F]FDG and [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 PET/CT were compared using paired-sample t tests.ResultsForty-seven patients (27 males, aged 25–68 years) with gastric cancer after curative resection (27 with adenocarcinoma, 17 with signet ring cell carcinoma and 4 with mucinous adenocarcinoma) were included in the study. [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 accumulation was significantly greater than that of [<jats:sup>18</jats:sup>F]FDG in terms of local recurrence (SUVmax, 11.65 vs 3.48, p&lt; 0.0001; TBR, 12.93 vs 2.94, p&lt; 0.0001), lymph node metastasis (SUVmax, 13.45 vs 3.05, p=0.003875; TBR, 12.43 vs 2.21, p=0.001661), and distant metastasis (SUVmax, 11.89 vs 2.96, p &lt; 0.0001; TBR, 13.32 vs 2.32, p&lt; 0.0001). Despite no statistical comparison was made with [<jats:sup>18</jats:sup>F]FDG, [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 imaging exhibited high levels of sensitivity, specificity, PPV, NPV, and accuracy for detecting postoperative local recurrence, lymph node metastasis, and distant metastasis in patients with gastric cancer.Conclusion[<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 has demonstrated potential for more accurate tumor re-evaluation in GC, thus enhancing treatment decision-making.","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative assessment of the diagnostic efficacy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT imaging for detecting postoperative recurrence in gastric cancer patients: a pilot study\",\"authors\":\"Jian Yang, Yong Wu, Yanyin Zhang, Xiang Peng, Chengzhi Jiang, Wanjing Zhou, Jiashun Dai, Aimin Xie, Hui Ye, Kai Zheng\",\"doi\":\"10.3389/fonc.2024.1427649\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PurposeThis study aimed to compare the efficacy of [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 PET/CT with that of [<jats:sup>18</jats:sup>F]FDG PET/CT for detecting postoperative recurrence in patients with gastric cancer.MethodsThis single-center retrospective clinical study was performed at Hunan Cancer Hospital between December 2020 and June 2022. The participants underwent both [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 and [<jats:sup>18</jats:sup>F]FDG within 14 days. Histopathologic examination, morphological imaging, and/or follow-up imaging were used as a reference for the final diagnosis. We recorded the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 and [<jats:sup>18</jats:sup>F]FDG PET/CT for detecting local recurrence, lymph node metastasis and distant metastasis. The SUVmax and background ratio (TBR) of local recurrence and metastases between [<jats:sup>18</jats:sup>F]FDG and [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 PET/CT were compared using paired-sample t tests.ResultsForty-seven patients (27 males, aged 25–68 years) with gastric cancer after curative resection (27 with adenocarcinoma, 17 with signet ring cell carcinoma and 4 with mucinous adenocarcinoma) were included in the study. [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 accumulation was significantly greater than that of [<jats:sup>18</jats:sup>F]FDG in terms of local recurrence (SUVmax, 11.65 vs 3.48, p&lt; 0.0001; TBR, 12.93 vs 2.94, p&lt; 0.0001), lymph node metastasis (SUVmax, 13.45 vs 3.05, p=0.003875; TBR, 12.43 vs 2.21, p=0.001661), and distant metastasis (SUVmax, 11.89 vs 2.96, p &lt; 0.0001; TBR, 13.32 vs 2.32, p&lt; 0.0001). Despite no statistical comparison was made with [<jats:sup>18</jats:sup>F]FDG, [<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 imaging exhibited high levels of sensitivity, specificity, PPV, NPV, and accuracy for detecting postoperative local recurrence, lymph node metastasis, and distant metastasis in patients with gastric cancer.Conclusion[<jats:sup>18</jats:sup>F]AlF-NOTA-FAPI-04 has demonstrated potential for more accurate tumor re-evaluation in GC, thus enhancing treatment decision-making.\",\"PeriodicalId\":12482,\"journal\":{\"name\":\"Frontiers in Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fonc.2024.1427649\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fonc.2024.1427649","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的 本研究旨在比较[18F]AlF-NOTA-FAPI-04 PET/CT与[18F]FDG PET/CT检测胃癌患者术后复发的疗效。方法 湖南省肿瘤医院于2020年12月至2022年6月期间开展了这项单中心回顾性临床研究。参与者在14天内同时接受[18F]AlF-NOTA-FAPI-04和[18F]FDG检查。组织病理学检查、形态学成像和/或随访成像作为最终诊断的参考。我们记录了[18F]AlF-NOTA-FAPI-04和[18F]FDG PET/CT检测局部复发、淋巴结转移和远处转移的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性。采用配对样本 t 检验比较了[18F]FDG 和[18F]AlF-NOTA-FAPI-04 PET/CT 检测局部复发和转移的 SUVmax 和背景比值（TBR）。[在局部复发（SUVmax，11.65 vs 3.48，p< 0.0001；TBR，12.93 vs 2.94，p< 0.0001）、淋巴结转移（SUVmax，13.45 vs 3.05，p=0.003875；TBR，12.43 vs 2.21，p=0.001661）和远处转移（SUVmax，11.89 vs 2.96，p< 0.0001；TBR，13.32 vs 2.32，p< 0.0001）。尽管没有与[18F]FDG进行统计学比较，但[18F]AlF-NOTA-FAPI-04成像在检测胃癌患者术后局部复发、淋巴结转移和远处转移方面表现出较高的敏感性、特异性、PPV、NPV和准确性。
Comparative assessment of the diagnostic efficacy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT imaging for detecting postoperative recurrence in gastric cancer patients: a pilot study
PurposeThis study aimed to compare the efficacy of [18F]AlF-NOTA-FAPI-04 PET/CT with that of [18F]FDG PET/CT for detecting postoperative recurrence in patients with gastric cancer.MethodsThis single-center retrospective clinical study was performed at Hunan Cancer Hospital between December 2020 and June 2022. The participants underwent both [18F]AlF-NOTA-FAPI-04 and [18F]FDG within 14 days. Histopathologic examination, morphological imaging, and/or follow-up imaging were used as a reference for the final diagnosis. We recorded the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT for detecting local recurrence, lymph node metastasis and distant metastasis. The SUVmax and background ratio (TBR) of local recurrence and metastases between [18F]FDG and [18F]AlF-NOTA-FAPI-04 PET/CT were compared using paired-sample t tests.ResultsForty-seven patients (27 males, aged 25–68 years) with gastric cancer after curative resection (27 with adenocarcinoma, 17 with signet ring cell carcinoma and 4 with mucinous adenocarcinoma) were included in the study. [18F]AlF-NOTA-FAPI-04 accumulation was significantly greater than that of [18F]FDG in terms of local recurrence (SUVmax, 11.65 vs 3.48, p< 0.0001; TBR, 12.93 vs 2.94, p< 0.0001), lymph node metastasis (SUVmax, 13.45 vs 3.05, p=0.003875; TBR, 12.43 vs 2.21, p=0.001661), and distant metastasis (SUVmax, 11.89 vs 2.96, p < 0.0001; TBR, 13.32 vs 2.32, p< 0.0001). Despite no statistical comparison was made with [18F]FDG, [18F]AlF-NOTA-FAPI-04 imaging exhibited high levels of sensitivity, specificity, PPV, NPV, and accuracy for detecting postoperative local recurrence, lymph node metastasis, and distant metastasis in patients with gastric cancer.Conclusion[18F]AlF-NOTA-FAPI-04 has demonstrated potential for more accurate tumor re-evaluation in GC, thus enhancing treatment decision-making.
期刊介绍：
Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.
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