Zhi Jie Goh, Ruiqi Li, Min Xian Wang, Po Ying Chia, Jue Tao Lim
{"title":"输注血液制品与登革热患者的临床疗效:系统回顾与荟萃分析","authors":"Zhi Jie Goh, Ruiqi Li, Min Xian Wang, Po Ying Chia, Jue Tao Lim","doi":"10.1093/ofid/ofae507","DOIUrl":null,"url":null,"abstract":"Introduction This systematic review and meta-analysis aimed to analyse the impacts of transfusing ‘non packed red blood cell’ blood products on patients with dengue and evaluate the effectiveness in reducing hospital stay, bleeding, mortality, and intensive care unit requirements. Methods Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomised or non-randomised studies which investigated the impacts of transfusion of blood products in patients with dengue. Results Nine studies were included in the final meta-analysis. Transfusion of blood products was associated with significantly higher mortality (9 studies, OR: 3.59, 95% CI: 1.07–15.98, I2 = 0%, p=0.04) and significantly longer length of hospital stay (6 studies, 0.56 days, 95% CI: 0.03–1.08, I2 = 95%, p=0.04). There was no significant difference in the incidence of clinical bleeding (7 studies, OR: 1.13, 95% CI: 0.77–1.65, I2 = 39%, p=0.54) or intensive care unit requirement (3 studies, OR: 1.59, 95% CI: 0.40–6.39, I2 = 0%, p=0.51). Conclusions Transfusing blood products for patients with dengue showed no benefit and may even be harmful.","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transfusion of blood products and clinical outcomes for dengue fever patients: a systematic review and meta-analysis\",\"authors\":\"Zhi Jie Goh, Ruiqi Li, Min Xian Wang, Po Ying Chia, Jue Tao Lim\",\"doi\":\"10.1093/ofid/ofae507\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction This systematic review and meta-analysis aimed to analyse the impacts of transfusing ‘non packed red blood cell’ blood products on patients with dengue and evaluate the effectiveness in reducing hospital stay, bleeding, mortality, and intensive care unit requirements. Methods Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomised or non-randomised studies which investigated the impacts of transfusion of blood products in patients with dengue. Results Nine studies were included in the final meta-analysis. Transfusion of blood products was associated with significantly higher mortality (9 studies, OR: 3.59, 95% CI: 1.07–15.98, I2 = 0%, p=0.04) and significantly longer length of hospital stay (6 studies, 0.56 days, 95% CI: 0.03–1.08, I2 = 95%, p=0.04). There was no significant difference in the incidence of clinical bleeding (7 studies, OR: 1.13, 95% CI: 0.77–1.65, I2 = 39%, p=0.54) or intensive care unit requirement (3 studies, OR: 1.59, 95% CI: 0.40–6.39, I2 = 0%, p=0.51). Conclusions Transfusing blood products for patients with dengue showed no benefit and may even be harmful.\",\"PeriodicalId\":19517,\"journal\":{\"name\":\"Open Forum Infectious Diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Forum Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ofid/ofae507\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofae507","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Transfusion of blood products and clinical outcomes for dengue fever patients: a systematic review and meta-analysis
Introduction This systematic review and meta-analysis aimed to analyse the impacts of transfusing ‘non packed red blood cell’ blood products on patients with dengue and evaluate the effectiveness in reducing hospital stay, bleeding, mortality, and intensive care unit requirements. Methods Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomised or non-randomised studies which investigated the impacts of transfusion of blood products in patients with dengue. Results Nine studies were included in the final meta-analysis. Transfusion of blood products was associated with significantly higher mortality (9 studies, OR: 3.59, 95% CI: 1.07–15.98, I2 = 0%, p=0.04) and significantly longer length of hospital stay (6 studies, 0.56 days, 95% CI: 0.03–1.08, I2 = 95%, p=0.04). There was no significant difference in the incidence of clinical bleeding (7 studies, OR: 1.13, 95% CI: 0.77–1.65, I2 = 39%, p=0.54) or intensive care unit requirement (3 studies, OR: 1.59, 95% CI: 0.40–6.39, I2 = 0%, p=0.51). Conclusions Transfusing blood products for patients with dengue showed no benefit and may even be harmful.
期刊介绍:
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.