{"title":"动态对比增强磁共振成像定量参数在评估接受新辅助化疗的宫颈癌患者疗效和病理分型中的应用评估与分析","authors":"Jie Cao, Zhihong Yang, Chunjing Yang, Yun Wu","doi":"10.1016/j.jrras.2024.101047","DOIUrl":null,"url":null,"abstract":"It was to demonstrate the therapeutic effects of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters (QPs) in cervical cancer (CC) patients undergoing neoadjuvant chemotherapy (NACT) and their role in evaluating pathological characteristics. Fifty CC patients were selected as CC group, received NACT, and underwent DCE-MRI scans pre- and post-treatment. Fifty normal cervical subjects were collected as Ctrl group. DCE-MRI QPs (K, K, V) of both groups were analyzed, along with changes in CC group before and after NACT, pathological subtypes, tumor differentiation degree, clinical staging, lymph node metastasis, and vascular invasion. The relationship between QPs and the pathological features was analyzed. The K, K, and V of CC group notably exceeded those of Ctrl group. The tumor shrinkage rate was positively correlated with the values of K, K, and V. The K value of squamous cell carcinoma (SCC) patients markedly exceeded that of adenocarcinoma patients. The K and K values of poorly differentiated tumors notably exceeded those of moderately/highly differentiated tumors. The K, K, and V values of stage IIb/III tumors notably exceeded those of stage I/Ia tumors, with all differences being considerable ( < 0.05). QPs differed inconsiderably between the two groups regarding lymph node metastasis and vascular invasion ( > 0.05). DCE-MRI QPs effectively reflect the vascular characteristics and hemodynamic changes of CC, and have evaluation value for the pathological subtypes, differentiation degree, and clinical staging of CC.","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation and analysis of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in assessing therapeutic efficacy and pathological typing of patients with cervical cancer undergoing neoadjuvant chemotherapy\",\"authors\":\"Jie Cao, Zhihong Yang, Chunjing Yang, Yun Wu\",\"doi\":\"10.1016/j.jrras.2024.101047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It was to demonstrate the therapeutic effects of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters (QPs) in cervical cancer (CC) patients undergoing neoadjuvant chemotherapy (NACT) and their role in evaluating pathological characteristics. Fifty CC patients were selected as CC group, received NACT, and underwent DCE-MRI scans pre- and post-treatment. Fifty normal cervical subjects were collected as Ctrl group. DCE-MRI QPs (K, K, V) of both groups were analyzed, along with changes in CC group before and after NACT, pathological subtypes, tumor differentiation degree, clinical staging, lymph node metastasis, and vascular invasion. The relationship between QPs and the pathological features was analyzed. The K, K, and V of CC group notably exceeded those of Ctrl group. The tumor shrinkage rate was positively correlated with the values of K, K, and V. The K value of squamous cell carcinoma (SCC) patients markedly exceeded that of adenocarcinoma patients. The K and K values of poorly differentiated tumors notably exceeded those of moderately/highly differentiated tumors. The K, K, and V values of stage IIb/III tumors notably exceeded those of stage I/Ia tumors, with all differences being considerable ( < 0.05). QPs differed inconsiderably between the two groups regarding lymph node metastasis and vascular invasion ( > 0.05). DCE-MRI QPs effectively reflect the vascular characteristics and hemodynamic changes of CC, and have evaluation value for the pathological subtypes, differentiation degree, and clinical staging of CC.\",\"PeriodicalId\":16920,\"journal\":{\"name\":\"Journal of Radiation Research and Applied Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radiation Research and Applied Sciences\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jrras.2024.101047\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radiation Research and Applied Sciences","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.jrras.2024.101047","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
该研究旨在证明动态对比增强磁共振成像(DCE-MRI)定量参数(QPs)对接受新辅助化疗(NACT)的宫颈癌(CC)患者的治疗效果及其在评估病理特征方面的作用。选取 50 名接受新辅助化疗的宫颈癌患者作为 CC 组,在治疗前后进行 DCE-MRI 扫描。收集 50 名正常宫颈受试者作为对照组。分析两组患者的DCE-MRI QPs(K、K、V),以及NACT前后CC组的变化、病理亚型、肿瘤分化程度、临床分期、淋巴结转移和血管侵犯情况。分析了 QPs 与病理特征之间的关系。CC组的K、K和V明显高于Ctrl组。鳞状细胞癌(SCC)患者的 K 值明显高于腺癌患者。分化较差的肿瘤的 K 值和 K 值明显高于中度/高度分化的肿瘤。IIb/III 期肿瘤的 K 值、K 值和 V 值明显超过 I/Ia 期肿瘤,所有差异都相当大(0.05)。DCE-MRI QPs能有效反映CC的血管特征和血流动力学变化,对CC的病理亚型、分化程度和临床分期具有评估价值。
Evaluation and analysis of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in assessing therapeutic efficacy and pathological typing of patients with cervical cancer undergoing neoadjuvant chemotherapy
It was to demonstrate the therapeutic effects of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters (QPs) in cervical cancer (CC) patients undergoing neoadjuvant chemotherapy (NACT) and their role in evaluating pathological characteristics. Fifty CC patients were selected as CC group, received NACT, and underwent DCE-MRI scans pre- and post-treatment. Fifty normal cervical subjects were collected as Ctrl group. DCE-MRI QPs (K, K, V) of both groups were analyzed, along with changes in CC group before and after NACT, pathological subtypes, tumor differentiation degree, clinical staging, lymph node metastasis, and vascular invasion. The relationship between QPs and the pathological features was analyzed. The K, K, and V of CC group notably exceeded those of Ctrl group. The tumor shrinkage rate was positively correlated with the values of K, K, and V. The K value of squamous cell carcinoma (SCC) patients markedly exceeded that of adenocarcinoma patients. The K and K values of poorly differentiated tumors notably exceeded those of moderately/highly differentiated tumors. The K, K, and V values of stage IIb/III tumors notably exceeded those of stage I/Ia tumors, with all differences being considerable ( < 0.05). QPs differed inconsiderably between the two groups regarding lymph node metastasis and vascular invasion ( > 0.05). DCE-MRI QPs effectively reflect the vascular characteristics and hemodynamic changes of CC, and have evaluation value for the pathological subtypes, differentiation degree, and clinical staging of CC.
期刊介绍:
Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.