Yumiko Tsushima, Noura Nachawi, Kevin M. Pantalone, Marcio L. Griebeler, Ula Abed Alwahab
{"title":"生酮饮食可提高多囊卵巢综合征患者的生育能力:简要报告","authors":"Yumiko Tsushima, Noura Nachawi, Kevin M. Pantalone, Marcio L. Griebeler, Ula Abed Alwahab","doi":"10.3389/fnut.2024.1395977","DOIUrl":null,"url":null,"abstract":"IntroductionPolycystic ovary syndrome (PCOS) affects up to 20 % of reproductive-age individuals and is strongly linked to obesity. The impacts of ketogenic diet on fertility in people with PCOS are unknown. This study aims to determine the effect of a ketogenic diet on restoration of regular menstrual cycles and fertility.MethodsAfter approval from the Institutional Review Boards of Cleveland Clinic, a retrospective analysis was conducted using the electronic health record system. We analyzed data from thirty patients (n = 30) with polycystic ovary syndrome who followed a ketogenic diet for at least 3 months at the Cleveland Clinic, Cleveland, Ohio, USA. Main outcomes were percentage of women with restoration of regular menstrual cycles and pregnancy rate.ResultsAll women (<jats:italic>n</jats:italic> = 30) had restoration of regular menstrual cycles. The overall pregnancy rate of women desiring pregnancy (<jats:italic>n</jats:italic> = 18) was 55.6% (<jats:italic>n</jats:italic> = 10). Pregnancy rate was 38.5% for women on metformin and 100% for those who were not (<jats:italic>P</jats:italic> = 0.036). Pregnancy rate was 62.5% for women using ovulation induction agents and 50.0% for those who did not (<jats:italic>P</jats:italic> = 0.66). Percent weight change between the pregnant and non-pregnant groups did not significantly differ [−8.1 ± 6.2, vs −6.4 ± 8.4, <jats:italic>P</jats:italic> = 0.64, respectively].ConclusionThis study reports a higher rate of pregnancy with the ketogenic diet in women with PCOS compared to existing literature.","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report\",\"authors\":\"Yumiko Tsushima, Noura Nachawi, Kevin M. Pantalone, Marcio L. Griebeler, Ula Abed Alwahab\",\"doi\":\"10.3389/fnut.2024.1395977\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"IntroductionPolycystic ovary syndrome (PCOS) affects up to 20 % of reproductive-age individuals and is strongly linked to obesity. The impacts of ketogenic diet on fertility in people with PCOS are unknown. This study aims to determine the effect of a ketogenic diet on restoration of regular menstrual cycles and fertility.MethodsAfter approval from the Institutional Review Boards of Cleveland Clinic, a retrospective analysis was conducted using the electronic health record system. We analyzed data from thirty patients (n = 30) with polycystic ovary syndrome who followed a ketogenic diet for at least 3 months at the Cleveland Clinic, Cleveland, Ohio, USA. Main outcomes were percentage of women with restoration of regular menstrual cycles and pregnancy rate.ResultsAll women (<jats:italic>n</jats:italic> = 30) had restoration of regular menstrual cycles. The overall pregnancy rate of women desiring pregnancy (<jats:italic>n</jats:italic> = 18) was 55.6% (<jats:italic>n</jats:italic> = 10). Pregnancy rate was 38.5% for women on metformin and 100% for those who were not (<jats:italic>P</jats:italic> = 0.036). Pregnancy rate was 62.5% for women using ovulation induction agents and 50.0% for those who did not (<jats:italic>P</jats:italic> = 0.66). Percent weight change between the pregnant and non-pregnant groups did not significantly differ [−8.1 ± 6.2, vs −6.4 ± 8.4, <jats:italic>P</jats:italic> = 0.64, respectively].ConclusionThis study reports a higher rate of pregnancy with the ketogenic diet in women with PCOS compared to existing literature.\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2024.1395977\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2024.1395977","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report
IntroductionPolycystic ovary syndrome (PCOS) affects up to 20 % of reproductive-age individuals and is strongly linked to obesity. The impacts of ketogenic diet on fertility in people with PCOS are unknown. This study aims to determine the effect of a ketogenic diet on restoration of regular menstrual cycles and fertility.MethodsAfter approval from the Institutional Review Boards of Cleveland Clinic, a retrospective analysis was conducted using the electronic health record system. We analyzed data from thirty patients (n = 30) with polycystic ovary syndrome who followed a ketogenic diet for at least 3 months at the Cleveland Clinic, Cleveland, Ohio, USA. Main outcomes were percentage of women with restoration of regular menstrual cycles and pregnancy rate.ResultsAll women (n = 30) had restoration of regular menstrual cycles. The overall pregnancy rate of women desiring pregnancy (n = 18) was 55.6% (n = 10). Pregnancy rate was 38.5% for women on metformin and 100% for those who were not (P = 0.036). Pregnancy rate was 62.5% for women using ovulation induction agents and 50.0% for those who did not (P = 0.66). Percent weight change between the pregnant and non-pregnant groups did not significantly differ [−8.1 ± 6.2, vs −6.4 ± 8.4, P = 0.64, respectively].ConclusionThis study reports a higher rate of pregnancy with the ketogenic diet in women with PCOS compared to existing literature.
期刊介绍:
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.