梅毒疫苗开发:使疫苗设计符合生产要求。

Sean Waugh,Caroline E Cameron
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引用次数: 0

摘要

由苍白螺旋体亚种引起的梅毒是一个全球性的健康问题,在全世界的发病率不断上升。目前的预防策略,包括筛查和治疗方法,都不足以解决感染率上升的问题,这就强调了疫苗的必要性。开发梅毒疫苗需要考虑一系列跨学科因素,包括基本的疾病特异性保护、技术要求、经济可行性、生产限制、公众接受度、疫苗的公平获取、与全球公共疫苗接种计划的一致性,以及确定需要接种疫苗以实现群体免疫的基本人群。梅毒疫苗开发的核心是优先考虑全球疫苗的可获得性,包括在中低收入环境中的可获得性。各种疫苗平台,包括亚单位、病毒样颗粒 (VLP)、mRNA 和外膜囊泡 (OMV) 疫苗,既有优势也有挑战。在整个临床前研究和开发阶段积极考虑生产的可行性和有效性,对于生产出有效、廉价和可推广的梅毒疫苗以应对该疾病造成的日益增长的全球健康负担至关重要。
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Syphilis vaccine development: Aligning vaccine design with manufacturing requirements.
Syphilis, caused by Treponema pallidum subsp. pallidum, is a global health concern with increasing rates worldwide. Current prevention strategies, including screen-and-treat approaches, are not sufficient to resolve rising infection rates, emphasizing the need for a vaccine. Developing a syphilis vaccine necessitates a range of cross-disciplinary considerations, including essential disease-specific protection, technical requirements, economic feasibility, manufacturing constraints, public acceptance, equitable vaccine access, alignment with global public vaccination programs, and identification of essential populations to be vaccinated to achieve herd immunity. Central to syphilis vaccine development is prioritization of global vaccine availability, including access in low- to middle-income settings. Various vaccine platforms, including subunit, virus-like particle (VLP), mRNA, and outer membrane vesicle (OMV) vaccines, present both advantages and challenges. The proactive consideration of both manufacturing feasibility and efficacy throughout the pre-clinical research and development stages is essential for producing an efficacious, inexpensive, and scalable syphilis vaccine to address the growing global health burden caused by this disease.
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
自引率
8.30%
发文量
0
审稿时长
1 months
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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