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Emerging insights into thyroid cancer from immunotherapy perspective: A bibliometric analysis. 从免疫疗法角度看甲状腺癌的新进展:文献计量分析。
IF 4.8 4区 医学 Pub Date : 2024-09-18 DOI: 10.1080/21645515.2024.2403170
Qianyu Wang,Gang Pan,Yu Zhang,Yiqin Ni,Yuzhu Mu,Dingcun Luo
Thyroid cancer is a common endocrine malignancy that poses considerable therapeutic challenges in treating anaplastic carcinoma and advanced aggressive disease. Immunotherapy has become a prominent strategy for cancer treatment, and has shown remarkable advancements in recent years. In this study, we utilized visualization and bibliometric tools to analyze publications on thyroid cancer immunotherapy from the Web of Science Core Collection (WoSCC). A total of 409 articles were included, with an annual increase in both publications and citations since 2016. China leads research efforts in this area, while the University of Texas System and UTMD Anderson Cancer Center rank first in publication output. The journal Thyroid has garnered the highest citations. Notable authors contributing to this field include Antonelli Alessandro, Fallahi Poupak, and Wang Yu. Current research hotspots include immune checkpoint inhibitors, combination therapies involving immunotherapy with targeted therapy, CAR-T cell therapy, and modulation of the tumor microenvironment, all of which underscore the evolving landscape and potential for innovative treatments in thyroid cancer.
甲状腺癌是一种常见的内分泌恶性肿瘤,在治疗无细胞癌和晚期侵袭性疾病方面面临着巨大的治疗挑战。免疫疗法已成为癌症治疗的重要策略,近年来取得了显著进展。在本研究中,我们利用可视化和文献计量学工具分析了科学网核心数据库(WoSCC)中有关甲状腺癌免疫疗法的文献。共收录了409篇文章,自2016年以来,发表量和引用量均呈逐年上升趋势。中国在这一领域的研究工作处于领先地位,而德克萨斯大学系统和UTMD安德森癌症中心在论文产出方面排名第一。甲状腺》杂志的引用率最高。在这一领域做出贡献的著名作者包括安东内利-亚历山德罗、法拉希-普帕克和王宇。目前的研究热点包括免疫检查点抑制剂、免疫疗法与靶向疗法的联合疗法、CAR-T细胞疗法以及肿瘤微环境调控,所有这些都凸显了甲状腺癌创新疗法不断发展的前景和潜力。
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引用次数: 0
COBRA N2 NA vaccines induce protective immune responses against influenza viral infection. COBRA N2 NA 疫苗可诱导针对流感病毒感染的保护性免疫反应。
IF 4.8 4区 医学 Pub Date : 2024-09-18 DOI: 10.1080/21645515.2024.2403175
Xiaojian Zhang,Amanda L Skarlupka,Hua Shi,Ted M Ross
Influenza neuraminidase (NA) is a promising target for a broadly protective vaccine. In this study, the Computationally Optimized Broadly Reactive Antigen (COBRA) methodology was used to develop N2 NA vaccine candidates. The unique wild type (WT) N2 sequences of human and swine influenza strains isolated between 1957 and 2019 were used to design the COBRA N2-A NA vaccine, while the unique WT N2 sequences of human influenza strains isolated between 2000 and 2019 were used to design the COBRA N2-B NA vaccine. Sera collected from COBRA N2 NA vaccinated mice showed more broadly reactive antibody responses against a broad panel of H×N2 influenza virus strains than sera collected from mice vaccinated with WT N2 NA vaccines. Antibodies elicited by COBRA or WT N2 NA antigens cross react with recent human H3N2 influenza viruses from different clades, while the antibodies elicited by A/Switzerland/9715293/2013 hemagglutinin (HA) reacted with viruses from the same clade. Furthermore, mice vaccinated with COBRA N2-B NA vaccine had lower viral lung titers compared to mock vaccinated mice when challenged with human H3N2 influenza viruses. Thus, the COBRA N2 NA vaccines elicit broadly protective murine anti-NA antibodies against multiple strains across subtypes and the viral loads were significantly decreased in the lungs of the mice in the COBRA N2 NA vaccine groups, compared to the mice in the mock vaccinated group, indicating that the COBRA-based N2 subtype NA vaccines have a potential to be a component in a universal influenza vaccine.
流感神经氨酸酶(NA)是一种具有广泛保护作用的疫苗的理想靶标。本研究采用计算优化广泛反应抗原(COBRA)方法开发N2 NA候选疫苗。利用1957年至2019年间分离的人流感和猪流感毒株的独特野生型(WT)N2序列设计了COBRA N2-A NA疫苗,而利用2000年至2019年间分离的人流感毒株的独特WT N2序列设计了COBRA N2-B NA疫苗。与接种WT N2 NA疫苗的小鼠血清相比,从接种COBRA N2 NA疫苗的小鼠血清中收集的针对H×N2流感病毒株的抗体反应更广泛。COBRA 或 WT N2 NA 抗原诱导的抗体与不同支系的近期人类 H3N2 流感病毒发生交叉反应,而 A/Switzerland/9715293/2013 血凝素(HA)诱导的抗体与同一支系的病毒发生反应。此外,与模拟接种小鼠相比,接种COBRA N2-B NA疫苗的小鼠在接受人类H3N2流感病毒挑战时,肺部病毒滴度较低。因此,COBRA N2 NA疫苗能针对多种亚型毒株激发广泛的保护性小鼠抗NA抗体,与模拟接种组相比,COBRA N2 NA疫苗组小鼠肺部的病毒载量显著降低,这表明基于COBRA的N2亚型NA疫苗有可能成为通用流感疫苗的组成部分。
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引用次数: 0
Factors influencing HPV vaccine hesitancy among university students in China: A cross-sectional survey utilizing the 3Cs model. 影响中国大学生HPV疫苗接种犹豫不决的因素:利用 3Cs 模型进行的横断面调查。
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2400750
Yuancheng He,Xiuqing Zhang,Jie Li,Yuehua Chen,Lin Zhang,Yuehong Wei
The HPV vaccine, which has been demonstrated to be an effective method of reducing the risk of developing cervical cancer, is still being underutilized among college students in China. To assess the current status of HPV vaccine hesitancy among college students in Guangdong Province after the COVID-19 outbreak, and to systematically analyze the influencing factors of HPV vaccine hesitancy and construct a prediction model based on the WHO 3Cs model. A cross-sectional web-based survey was conducted in June 2023 among female college students in four cities in Guangdong Province. The data were analyzed using binary logistic regression with a focus on the 3Cs model: Complacency, Convenience, and Confidence. LASSO regression was employed to analyze the variables deemed to be of significance and to construct predictive models. Out of 1399 participants, 86.5% expressed no hesitancy toward HPV vaccination. However, 11.9% exhibited hesitancy, and 1.6% refused vaccination altogether. Factors such as trust in vaccine efficacy, perception of HPV infection risk, price considerations, and constraints like distance or time were significant contributors to hesitancy. Knowledge of the HPV vaccine, socio-demographic characteristics, and the educational level of participants' mothers also played a role in vaccine hesitancy. It is recommended that targeted interventions be implemented within educational institutions with the aim of raising awareness of cervical cancer and HPV vaccines, simplifying the scheduling of vaccination appointments, and increasing affordability through the implementation of strategic purchasing measures or subsidy schemes.
HPV疫苗已被证明是降低宫颈癌发病风险的有效方法,但在中国的大学生中仍未得到充分利用。为了评估COVID-19疫情爆发后广东省大学生HPV疫苗接种犹豫的现状,系统分析HPV疫苗接种犹豫的影响因素,并基于WHO 3Cs模型构建预测模型。研究于2023年6月对广东省四个城市的女大学生进行了横断面网络调查。数据采用二元逻辑回归分析,重点关注 3Cs 模型:自满(Complacency)、便利(Convenience)和信心(Confidence)。采用 LASSO 回归分析被认为具有重要意义的变量,并构建预测模型。在 1399 名参与者中,86.5% 表示对接种 HPV 疫苗没有犹豫。然而,有 11.9% 的人表示犹豫不决,1.6% 的人完全拒绝接受疫苗接种。对疫苗疗效的信任、对 HPV 感染风险的认知、价格因素以及距离或时间等限制因素是导致犹豫不决的重要原因。对 HPV 疫苗的了解、社会人口特征以及参与者母亲的教育水平也是造成犹豫不决的原因之一。建议在教育机构内实施有针对性的干预措施,以提高人们对宫颈癌和 HPV 疫苗的认识,简化疫苗接种预约的时间安排,并通过实施战略性采购措施或补贴计划来提高人们的经济承受能力。
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引用次数: 0
Human vaccines and immunotherapeutics: News August 2024 人类疫苗和免疫疗法:2024 年 8 月新闻
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2402171
Ronald Ellis, Adam Weiss
Published in Human Vaccines & Immunotherapeutics (Vol. 20, No. 1, 2024)
发表于《人类疫苗与免疫治疗》(第 20 卷第 1 期,2024 年)
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引用次数: 0
Uptake, adverse effect, and associated factors of COVID-19 vaccine among those living with human immunodeficiency virus, at Bole sub-city health facility Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴 Bole 次城市卫生机构中人类免疫缺陷病毒感染者对 COVID-19 疫苗的接种率、不良反应及相关因素
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2389576
Sendu Seid, Teferi Gebru Gebremeskel
COVID-19 vaccination in African people living with human immunodeficiency virus remains understudied, with limited research in Ethiopia that fails to consider contextual differences. To assess upta...
对非洲人类免疫缺陷病毒感染者接种 COVID-19 疫苗的研究仍然不足,在埃塞俄比亚进行的研究有限,而且没有考虑到环境差异。为了评估非洲人感染人类免疫缺陷病毒后接种 COVID-19
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引用次数: 0
Immunotherapy and delivery systems for melanoma 黑色素瘤的免疫疗法和给药系统
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2394252
Hui Liu, Xi Gou, Yuanfang Tan, Qiuying Fan, Juanjuan Chen
Melanoma is a highly malignant tumor of melanocyte origin that is prone to early metastasis and has a very poor prognosis. Early melanoma treatment modalities are mainly surgical, and treatment str...
黑色素瘤是一种黑色素细胞来源的高度恶性肿瘤,易发生早期转移,预后极差。早期黑色素瘤的治疗方式主要是外科手术,而治疗步骤主要是化疗和放疗。
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引用次数: 0
A cross-sectional study on the understanding and attitudes toward influenza and influenza vaccines among different occupational groups in China. 关于中国不同职业人群对流感和流感疫苗的理解和态度的横断面研究。
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2397214
Xinkun Zhao,Xin Hu,Junyi Wang,Mingshuai Shen,Kaifeng Zhou,Xianjie Han,Milton Thomas,Kezhou Wang,Li Wang,Zhao Wang
This study aimed to assess the level of knowledge regarding influenza viruses and vaccines among different professional groups to investigate the reasons for vaccine hesitancy. We collected 2190 questionnaires regarding influenza vaccines in China in 2022. The respondents were categorized into the general population (GP), foreign affairs workforce population (FAWP), and veterinary workforce population (VWP) according to their job positions. Linear regression was used to assess the association between multiple factors and influenza vaccination rates. The association between work and influenza vaccination rates was also assessed by grouping different workforce populations. The vaccination rate of the GP was higher than that of the VWP (odds ratio: 1.342, 95% confidence interval: 1.025-1.853), surpassing the rates reported in previous studies. This may be attributed to heightened concerns about infectious diseases influenced by the ongoing coronavirus disease 2019 pandemic. Despite the VWP's more in-depth knowledge of the VWP on zoonotic diseases and their recognition of their importance, there was no significant difference in influenza knowledge among the three populations. This discrepancy contrasts with the observed differences in vaccination rates. Further investigation revealed that, compared with FAWP, the price of vaccines emerged as a primary influencing factor for vaccination rates (odds ratio:0.398, 95%CI; 0.280-0.564). General concerns regarding the protective effects and side effects of vaccines were also noted.
本研究旨在评估不同职业人群对流感病毒和疫苗的认知水平,从而调查疫苗接种犹豫不决的原因。2022 年,我们在中国收集了 2190 份有关流感疫苗的问卷。受访者根据工作岗位被分为普通人群(GP)、外事工作人群(FAWP)和兽医工作人群(VWP)。采用线性回归法评估多种因素与流感疫苗接种率之间的关系。此外,还通过对不同劳动力人群进行分组,评估了工作与流感疫苗接种率之间的关联。全科医生的接种率高于大众医生(几率比:1.342,95% 置信区间:1.025-1.853),超过了以往研究中报告的接种率。这可能是由于受到 2019 年冠状病毒疾病大流行的影响,人们对传染病的担忧加剧。尽管万博滚球电竞对人畜共患疾病有更深入的了解,并认识到其重要性,但三个人群在流感知识方面没有显著差异。这一差异与观察到的疫苗接种率差异形成了鲜明对比。进一步调查显示,与非洲裔妇女和儿童相比,疫苗价格是影响疫苗接种率的主要因素(几率比:0.398,95%CI;0.280-0.564)。此外,人们还普遍关注疫苗的保护作用和副作用。
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引用次数: 0
Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021-23. 孕期接种疫苗对降低 12 个月以下婴儿感染 SARS-CoV-2 的风险的效果。普利亚(意大利),2021-23。
IF 4.8 4区 医学 Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2403831
Cesare De Virgilio Suglia,Pasquale Stefanizzi,Giusy Graziano,Lorenza Moscara,Arianna Delle Fontane,Martina Minelli,Silvio Tafuri
This retrospective cohort study evaluated the effectiveness of maternal vaccination against COVID-19 in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. The study, conducted at the "Policlinico" University Hospital of Bari, included 3346 newborns and their mothers. The study explored the degree of protection offered by maternal vaccination depending on the timing, type, and trimester of vaccination, also taking into account the mother's history of infection. We compared the incidence rate of infection between children of vaccinated and unvaccinated mothers; the values were 10.2% and 18.1%, respectively, and the difference was statistically significant. The overall effectiveness of the vaccine against the infection was 45%. Further analysis revealed increasing efficacy as the doses of vaccine administered to the mother increased and in case of a previous history of maternal infection. Dual immune stimulation (vaccination and natural infection) was 83% effective in preventing infection among newborns. The multivariable models confirmed the protective effect of vaccination with all types of vaccines used. The analysis of infection's incidence in newborns revealed an interesting temporal trend, with increasing incidence with time, suggesting a possible correlation with the persistence of maternal antibodies or with the gradual weaning. The results on the protective capacity of vaccines are in line with the global literature. Strengths of study include sample size, robust methodology, and multivariate analyses. Institutions could intensify awareness campaigns to encourage both pregnant women and all those who would like to become pregnant to receive SARS-CoV-2 vaccination.
这项回顾性队列研究评估了产妇接种 COVID-19 疫苗对降低 12 个月以下婴儿感染 SARS-CoV-2 风险的有效性。这项研究在巴里 "Policlinico "大学医院进行,共有 3346 名新生儿及其母亲参加。这项研究探讨了母亲接种疫苗的保护程度,这取决于接种疫苗的时间、类型和孕期,同时也考虑到了母亲的感染史。我们比较了接种疫苗和未接种疫苗母亲的子女的感染率,其数值分别为 10.2% 和 18.1%,差异具有统计学意义。疫苗对感染的总体有效率为 45%。进一步的分析表明,随着母亲接种疫苗剂量的增加,以及母亲曾有过感染史,疫苗的有效性也会增加。双重免疫刺激(疫苗接种和自然感染)对预防新生儿感染的有效率为 83%。多变量模型证实了接种所有类型疫苗的保护效果。对新生儿感染率的分析发现了一个有趣的时间趋势,即感染率随着时间的推移而增加,这表明可能与母体抗体的持续存在或逐渐断奶有关。关于疫苗保护能力的研究结果与全球文献一致。研究的优点包括样本量大、方法稳健和多变量分析。医疗机构可以加强宣传活动,鼓励孕妇和所有希望怀孕的妇女接种 SARS-CoV-2 疫苗。
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引用次数: 0
Coverage of influenza vaccination and influencing factors among healthcare workers in Shandong Province, China, 2021–2022 2021-2022 年中国山东省医护人员流感疫苗接种覆盖率及影响因素
IF 4.8 4区 医学 Pub Date : 2024-09-16 DOI: 10.1080/21645515.2024.2402116
Yuwei Liu, Ti Liu, Mingxiao Yao, Qiang Wang, Renpeng Li, Zengqiang Kou
Healthcare workers (HCWs) are at increased risk of exposure to the influenza virus in their daily clinical and disease prevention activities, making them a high-risk group for influenza infection. ...
医护人员在日常临床和疾病预防活动中接触流感病毒的风险增加,因此他们是流感感染的高危人群。...
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引用次数: 0
Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant 作为疫苗佐剂的硫酸化乳糖古菌素(SLA)古菌体
IF 4.8 4区 医学 Pub Date : 2024-09-15 DOI: 10.1080/21645515.2024.2395081
Bassel Akache, Michael J. McCluskie
Archaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have...
考古体是一种脂质体,传统上由全极性脂质或半合成甘油脂质组成,其核心是具有不同乙二醇和氨基头基的醚键异戊二烯植物烷基。我们已经...
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引用次数: 0
期刊
Human Vaccines & Immunotherapeutics
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