Katherine N. Thompson, Olakunle Oginni, Jasmin Wertz, Andrea Danese, Malaika Okundi, Louise Arseneault, Timothy Matthews
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引用次数: 0
摘要
我们评估了遗传和环境对儿童期社会隔离的影响,以及社会隔离与心理健康症状(包括抑郁症状、品行问题和青春期至青年期的精神病样经历)之间的重叠。研究对象包括环境风险纵向双胞胎研究中的 2,232 名儿童。社会隔离度在 5、7、10、12 和 18 岁时进行测量。采用 Cholesky 分解法估算了 5、7、10 和 12 岁时遗传和环境对社会隔离的影响。独立路径模型用于评估遗传(A)、共享环境(C)和非共享环境(E)对 12 至 18 岁期间社会隔离与心理健康问题重叠的影响。遗传和非共享环境影响占童年社会隔离差异的一半。遗传因素使儿童时期的社会隔离具有连续性,而非共同环境因素则具有年龄特异性。社会隔离与心理健康症状之间的纵向重叠在很大程度上是由抑郁症状(r = 0.15-0.24: 82-84% A, 11-12% C, and 5-6% E)和精神病样经历(r = 0.13-0.15: 81-91% A, 0-8% C, and 9-11% E)的遗传影响所解释的,但行为问题(r = 0.13-0.16; 0-42% A, 42-81% C, 16-24% E)则不是。我们的研究结果强调,社会隔离与其说是一种风险因素或结果,不如说是与心理健康状况不佳交织在一起的病因。对社会隔离的综合评估可以作为青少年潜在心理健康症状的一个有用指标。
Social isolation and poor mental health in young people: testing genetic and environmental influences in a longitudinal cohort study
We assessed genetic and environmental influences on social isolation across childhood and the overlap between social isolation and mental health symptoms including depression symptoms, conduct problems, and psychotic-like experiences from adolescence to young adulthood. Participants included 2,232 children from the Environmental Risk Longitudinal Twin Study. Social isolation was measured at ages 5, 7, 10, 12, and 18. A Cholesky decomposition was specified to estimate the genetic and environmental influences on social isolation across ages 5, 7, 10, and 12. An independent pathway model was used to assess additive genetic (A), shared environmental (C), and non-shared environmental (E) influences on the overlap between social isolation and mental health problems from age 12 to 18. Genetic and non-shared environmental influences accounted for half of the variance in childhood social isolation. Genetic influences contributed to the continuity of social isolation across childhood, while non-shared environmental influences were age-specific. The longitudinal overlap between social isolation and mental health symptoms was largely explained by genetic influences for depression symptoms (r = 0.15–0.24: 82–84% A, 11–12% C, and 5–6% E) and psychotic-like experiences (r = 0.13–0.15: 81–91% A, 0–8% C, and 9–11% E) but not conduct problems (r = 0.13–0.16; 0–42% A, 42–81% C, 16–24% E). Our findings emphasise that rather than a risk factor or an outcome, social isolation is aetiologically intertwined with the experience of poor mental health. An integrative assessment of social isolation could be a helpful indicator of underlying mental health symptoms in young people.
期刊介绍:
European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark.
European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.