将铕金属有机框架从三维通过二维转化为用于酶固定的剥离三维

IF 7.5 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Communications Materials Pub Date : 2024-09-12 DOI:10.1038/s43246-024-00624-y
Ani Vardanyan, Guojun Zhou, Nayoung Kim, Tetyana M. Budnyak, Vadim G. Kessler, Insung S. Choi, Zhehao Huang, Gulaim A. Seisenbaeva
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引用次数: 0

摘要

金属有机框架(MOFs)已成为极具潜力的承载功能性生物分子的材料。在这里,一种具有扁平不对称形状的 1,2,4-苯三羧酸配体被用于为三维铕 MOF(SLU-1)注入不寻常的行为。溶剂的添加会导致三维 MOF 分裂成二维 MOF(SLU-2),而在过量水的情况下,又会交联成另一种容易自发剥离的三维 MOF(SLU-3)。SLU-3 兼具高亲水性和疏水性的特点,是加入大型活性物质的理想宿主。作为一个代表性的示范,辣根过氧化物酶(HRP)通过简单的混合被加入到剥离的三维层状结构中,并以核壳结构的形式被外层二氧化硅层固定。由此产生的基于 HRP 的生物催化剂具有更高的稳定性和可重复使用性,能有效降解苯酚。这项工作展示了可重构 MOFs 的潜力,通过控制生物催化剂的吸收和保留,提供了可持续的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Transformation of europium metal-organic framework from 3D via 2D into exfoliating 3D for enzyme immobilization
Metal-organic frameworks (MOFs) have emerged as highly promising materials for hosting functional biomolecules. Here, a 1,2,4-benzenetricarboxylate ligand with a flat asymmetric shape is applied to infuse an unusual behavior to a 3D europium MOF (SLU-1). Solvent addition results in the 3D MOF splitting into a 2D one (SLU-2), and in the presence of excess water, gets cross-linked into a different 3D MOF (SLU-3) prone to spontaneous exfoliation. SLU-3 features a combination of highly hydrophilic and hydrophobic spots and serves as an attractive host for incorporating large active species. As a representative demonstration, horseradish peroxidase (HRP) is incorporated into the exfoliated 3D-layered structure by simple mixing, and secured by an outer silica layer in the form of core-shell structures. The resulting HRP-based biocatalyst exhibited enhanced stability and reusability, effectively degrading phenol. This work showcases the potential of reconfigurable MOFs, offering upheld applications through the controlled uptake and retention of biocatalytic agents. Metal-organic frameworks are promising materials for hosting functional biomolecules. Here, a 3D europium metal-organic framework could split into a 2D one upon solvent addition and re-cross-link to 3D with excess solvent which can host enzymes as a biocatalyst.
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来源期刊
Communications Materials
Communications Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
12.10
自引率
1.30%
发文量
85
审稿时长
17 weeks
期刊介绍: Communications Materials, a selective open access journal within Nature Portfolio, is dedicated to publishing top-tier research, reviews, and commentary across all facets of materials science. The journal showcases significant advancements in specialized research areas, encompassing both fundamental and applied studies. Serving as an open access option for materials sciences, Communications Materials applies less stringent criteria for impact and significance compared to Nature-branded journals, including Nature Communications.
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