João Pedro C. Silva, Domingos R. Santos-Neto, Carlos E. C. Lopes, Luiz R. G. Silva, Luiza M. F. Dantas, Iranaldo S. da Silva
{"title":"快速便携测定羟氯喹的高灵敏度吸附电化学方法","authors":"João Pedro C. Silva, Domingos R. Santos-Neto, Carlos E. C. Lopes, Luiz R. G. Silva, Luiza M. F. Dantas, Iranaldo S. da Silva","doi":"10.1007/s10008-024-06032-z","DOIUrl":null,"url":null,"abstract":"<p>On March 11, 2020, the World Health Organization declared the coronavirus disease pandemic, caused by the SARS-CoV-2 virus. This declaration propelled the drug hydroxychloroquine into the global spotlight, as it was identified as a potential early treatment for the disease. Consequently, there was a surge in its consumption worldwide, particularly in Brazil. This increased usage has raised concerns about the potential contamination of natural water sources. In response to this concern, the present study proposes an electroanalytical method for detecting hydroxychloroquine in pharmaceutical and drinking water samples. The method aims to study the effects of modifying the sensor with carbon black Super P for HCQ detection, as well as improving the reproducibility and repeatability of the SPCB/GCE. The detection method and sensor modification have been thoroughly optimized for hydroxychloroquine detection. The optimal analysis conditions were established with a concentration of 5.0 mg mL<sup>−1</sup> of SPCB, a pH of 7.00, and a preconcentration time of 2 min. The detection and quantification limits were determined to be 0.0093 µmol L<sup>−1</sup> and 0.0312 µmol L<sup>−1</sup>, respectively, with a linear range between 0.10 and 10.0 µmol L<sup>−1</sup>. Analyses conducted on fortified samples indicated recovery responses of 110% for tap water and 100.5% for drug samples, demonstrating the method’s high accuracy, particularly for pharmaceutical samples.</p>","PeriodicalId":665,"journal":{"name":"Journal of Solid State Electrochemistry","volume":"8 1","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A high sensitivity adsorptive-electrochemical method for rapid and portable determination of hydroxychloroquine\",\"authors\":\"João Pedro C. Silva, Domingos R. Santos-Neto, Carlos E. C. Lopes, Luiz R. G. Silva, Luiza M. F. Dantas, Iranaldo S. da Silva\",\"doi\":\"10.1007/s10008-024-06032-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>On March 11, 2020, the World Health Organization declared the coronavirus disease pandemic, caused by the SARS-CoV-2 virus. This declaration propelled the drug hydroxychloroquine into the global spotlight, as it was identified as a potential early treatment for the disease. Consequently, there was a surge in its consumption worldwide, particularly in Brazil. This increased usage has raised concerns about the potential contamination of natural water sources. In response to this concern, the present study proposes an electroanalytical method for detecting hydroxychloroquine in pharmaceutical and drinking water samples. The method aims to study the effects of modifying the sensor with carbon black Super P for HCQ detection, as well as improving the reproducibility and repeatability of the SPCB/GCE. The detection method and sensor modification have been thoroughly optimized for hydroxychloroquine detection. The optimal analysis conditions were established with a concentration of 5.0 mg mL<sup>−1</sup> of SPCB, a pH of 7.00, and a preconcentration time of 2 min. The detection and quantification limits were determined to be 0.0093 µmol L<sup>−1</sup> and 0.0312 µmol L<sup>−1</sup>, respectively, with a linear range between 0.10 and 10.0 µmol L<sup>−1</sup>. Analyses conducted on fortified samples indicated recovery responses of 110% for tap water and 100.5% for drug samples, demonstrating the method’s high accuracy, particularly for pharmaceutical samples.</p>\",\"PeriodicalId\":665,\"journal\":{\"name\":\"Journal of Solid State Electrochemistry\",\"volume\":\"8 1\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Solid State Electrochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s10008-024-06032-z\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ELECTROCHEMISTRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solid State Electrochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10008-024-06032-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}
A high sensitivity adsorptive-electrochemical method for rapid and portable determination of hydroxychloroquine
On March 11, 2020, the World Health Organization declared the coronavirus disease pandemic, caused by the SARS-CoV-2 virus. This declaration propelled the drug hydroxychloroquine into the global spotlight, as it was identified as a potential early treatment for the disease. Consequently, there was a surge in its consumption worldwide, particularly in Brazil. This increased usage has raised concerns about the potential contamination of natural water sources. In response to this concern, the present study proposes an electroanalytical method for detecting hydroxychloroquine in pharmaceutical and drinking water samples. The method aims to study the effects of modifying the sensor with carbon black Super P for HCQ detection, as well as improving the reproducibility and repeatability of the SPCB/GCE. The detection method and sensor modification have been thoroughly optimized for hydroxychloroquine detection. The optimal analysis conditions were established with a concentration of 5.0 mg mL−1 of SPCB, a pH of 7.00, and a preconcentration time of 2 min. The detection and quantification limits were determined to be 0.0093 µmol L−1 and 0.0312 µmol L−1, respectively, with a linear range between 0.10 and 10.0 µmol L−1. Analyses conducted on fortified samples indicated recovery responses of 110% for tap water and 100.5% for drug samples, demonstrating the method’s high accuracy, particularly for pharmaceutical samples.
期刊介绍:
The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry.
The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces.
The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis.
The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.