快速便携测定羟氯喹的高灵敏度吸附电化学方法

IF 2.6 4区 化学 Q3 ELECTROCHEMISTRY Journal of Solid State Electrochemistry Pub Date : 2024-08-12 DOI:10.1007/s10008-024-06032-z
João Pedro C. Silva, Domingos R. Santos-Neto, Carlos E. C. Lopes, Luiz R. G. Silva, Luiza M. F. Dantas, Iranaldo S. da Silva
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引用次数: 0

摘要

2020 年 3 月 11 日,世界卫生组织宣布由 SARS-CoV-2 病毒引起的冠状病毒疾病大流行。这一宣布将羟氯喹药物推向了全球的聚光灯下,因为它被认为是一种潜在的疾病早期治疗药物。因此,羟氯喹在全球的消费量激增,尤其是在巴西。使用量的增加引起了人们对天然水源可能受到污染的担忧。针对这种担忧,本研究提出了一种电分析方法,用于检测药品和饮用水样本中的羟氯喹。该方法旨在研究用超级 P 炭黑改性传感器对检测 HCQ 的影响,以及提高 SPCB/GCE 的重现性和重复性。针对羟氯喹的检测,对检测方法和传感器改性进行了全面优化。最佳分析条件为 SPCB 浓度为 5.0 mg mL-1、pH 值为 7.00、预浓缩时间为 2 分钟。检测限和定量限分别为 0.0093 µmol L-1 和 0.0312 µmol L-1,线性范围在 0.10 至 10.0 µmol L-1 之间。对强化样品进行的分析表明,自来水的回收率为 110%,药物样品的回收率为 100.5%,这表明该方法的准确度很高,尤其适用于药物样品。
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A high sensitivity adsorptive-electrochemical method for rapid and portable determination of hydroxychloroquine

On March 11, 2020, the World Health Organization declared the coronavirus disease pandemic, caused by the SARS-CoV-2 virus. This declaration propelled the drug hydroxychloroquine into the global spotlight, as it was identified as a potential early treatment for the disease. Consequently, there was a surge in its consumption worldwide, particularly in Brazil. This increased usage has raised concerns about the potential contamination of natural water sources. In response to this concern, the present study proposes an electroanalytical method for detecting hydroxychloroquine in pharmaceutical and drinking water samples. The method aims to study the effects of modifying the sensor with carbon black Super P for HCQ detection, as well as improving the reproducibility and repeatability of the SPCB/GCE. The detection method and sensor modification have been thoroughly optimized for hydroxychloroquine detection. The optimal analysis conditions were established with a concentration of 5.0 mg mL−1 of SPCB, a pH of 7.00, and a preconcentration time of 2 min. The detection and quantification limits were determined to be 0.0093 µmol L−1 and 0.0312 µmol L−1, respectively, with a linear range between 0.10 and 10.0 µmol L−1. Analyses conducted on fortified samples indicated recovery responses of 110% for tap water and 100.5% for drug samples, demonstrating the method’s high accuracy, particularly for pharmaceutical samples.

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来源期刊
CiteScore
4.80
自引率
4.00%
发文量
227
审稿时长
4.1 months
期刊介绍: The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.
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