低剂量白细胞介素-2治疗桦树花粉过敏：第2阶段随机双盲安慰剂对照试验

medRxiv - Allergy and Immunology Pub Date : 2024-09-04 DOI:10.1101/2024.09.04.24312986

M Rosenzwajg, A Gherasim, F Dietsch, M. Beck, N Domis, R Lorenzon, Yannick Chantran, B Bellier, E Vicaut, A Soria, F De Blay, D Klatzmann

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摘要

背景调节性 T 细胞（Tregs）在对过敏原的免疫耐受中起着关键作用。低剂量 IL-2（IL-2LD）可扩增和激活 Tregs。我们评估了 IL-2LD 对控制过敏原暴露临床反应的功效。

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Low-dose interleukin-2 in birch pollen allergy: a phase-2 randomized double-blind placebo-controlled trial

Background Regulatory T cells (Tregs) are pivotal in immune tolerance to allergens. Low-dose IL-2 (IL-2_LD) expands and activates Tregs. We assessed IL-2_LD efficacy for controlling clinical responses to allergen exposures.

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medRxiv - Allergy and Immunology

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