Dispersive solid phase extraction of fluoroquinolone antibiotic residues in raw cow milk samples using bimetallic organic frameworks and investigating the effect of UV irradiation on antibiotics decontamination

The determination of antibiotic residues in animal–derived foods is an important issue in the field of food safety considering their residues side effects on consumers health. Therefore, recommendation an efficient analytical procedure for determination of these pollutants is of great importance. In the current work, a dispersive solid phase extraction in which bimetallic metal–organic framework is used as sorbent has been developed for extraction of some fluoroquinolone antibiotics from raw cow milk samples. The extracted analytes are determined using high performance liquid chromatography–fluorescence detector. The influence of exposing the milk samples to ultraviolet irradiations on the decontamination of antibiotics has also been investigated. Low limits of detection (5–11 ng L) and quantification (17–37 ng L), acceptable extraction recovery (63–76 %), and high repeatability (≤5.3 %) were accessed for analytes using the proposed analytical procedure under the optimum conditions. Various cow milk samples were analyzed with the proposed procedure under the optimum conditions and based on the outcomes, none of the tested samples were polluted with fluoroquinolone antibiotics. Also, the effect of samples matrix was evaluated by standard addition method and the mean relative recoveries were in the range of 86–102 %.