{"title":"基于钼掺杂氧化石墨烯纳米棒锚定碳球/五氧化二钒纳米复合材料的电化学传感器,用于同时测定双氯芬酸钠和泊沙康唑","authors":"Marwa R. El-Zahry","doi":"10.1016/j.microc.2024.111593","DOIUrl":null,"url":null,"abstract":"Herein, the current study describes a simple and low-cost electrochemical platform for simultaneous estimation of diclofenac sodium (DCF) and posaconazole (POS) that is proved to be effective treatment of fungal mycetoma. Molybdenum-doped graphene oxide nanorods anchored carbon sphere-doped vanadium oxide nanocomposites were developed using co-precipitation method. The electrochemical measurements were conducted using square wave voltammetric (SWV) technique in optimal conditions. The designed modified electrode showed excellent voltammetric responses towards DCF and POS with 0.18 V difference in the oxidation peak potentials, making the developed modified nano-sensor suitable for simultaneous determination of the interested compounds. The physico-chemical properties of the fabricated nanocomposites were characterized by cyclic voltammetry, scanning electron microscope, powder X-ray diffraction, infrared spectroscopy, and electrochemical impedance spectroscopy. In terms of low limits of detection (LOD) 10.2 nM DCF and 3.81 nM POS, the established voltammetric sensor provided worthy analytical behavior for sensing DCF and POS. The applicability of the designed senor was effectively presented in the spiked human urine and plasma samples.","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical sensor based on molybdenum-doped graphene oxide nanorods anchored carbon spheres/vanadium pentoxide nanocomposites for simultaneous determination of diclofenac sodium and posaconazole\",\"authors\":\"Marwa R. El-Zahry\",\"doi\":\"10.1016/j.microc.2024.111593\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Herein, the current study describes a simple and low-cost electrochemical platform for simultaneous estimation of diclofenac sodium (DCF) and posaconazole (POS) that is proved to be effective treatment of fungal mycetoma. Molybdenum-doped graphene oxide nanorods anchored carbon sphere-doped vanadium oxide nanocomposites were developed using co-precipitation method. The electrochemical measurements were conducted using square wave voltammetric (SWV) technique in optimal conditions. The designed modified electrode showed excellent voltammetric responses towards DCF and POS with 0.18 V difference in the oxidation peak potentials, making the developed modified nano-sensor suitable for simultaneous determination of the interested compounds. The physico-chemical properties of the fabricated nanocomposites were characterized by cyclic voltammetry, scanning electron microscope, powder X-ray diffraction, infrared spectroscopy, and electrochemical impedance spectroscopy. In terms of low limits of detection (LOD) 10.2 nM DCF and 3.81 nM POS, the established voltammetric sensor provided worthy analytical behavior for sensing DCF and POS. The applicability of the designed senor was effectively presented in the spiked human urine and plasma samples.\",\"PeriodicalId\":391,\"journal\":{\"name\":\"Microchemical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchemical Journal\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.microc.2024.111593\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.microc.2024.111593","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Electrochemical sensor based on molybdenum-doped graphene oxide nanorods anchored carbon spheres/vanadium pentoxide nanocomposites for simultaneous determination of diclofenac sodium and posaconazole
Herein, the current study describes a simple and low-cost electrochemical platform for simultaneous estimation of diclofenac sodium (DCF) and posaconazole (POS) that is proved to be effective treatment of fungal mycetoma. Molybdenum-doped graphene oxide nanorods anchored carbon sphere-doped vanadium oxide nanocomposites were developed using co-precipitation method. The electrochemical measurements were conducted using square wave voltammetric (SWV) technique in optimal conditions. The designed modified electrode showed excellent voltammetric responses towards DCF and POS with 0.18 V difference in the oxidation peak potentials, making the developed modified nano-sensor suitable for simultaneous determination of the interested compounds. The physico-chemical properties of the fabricated nanocomposites were characterized by cyclic voltammetry, scanning electron microscope, powder X-ray diffraction, infrared spectroscopy, and electrochemical impedance spectroscopy. In terms of low limits of detection (LOD) 10.2 nM DCF and 3.81 nM POS, the established voltammetric sensor provided worthy analytical behavior for sensing DCF and POS. The applicability of the designed senor was effectively presented in the spiked human urine and plasma samples.
期刊介绍:
The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field.
Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.