聚对苯二甲酸(PDLLA)在皮肤科中的应用:文献综述

IF 4.7 3区 工程技术 Q1 POLYMER SCIENCE Polymers Pub Date : 2024-09-13 DOI:10.3390/polym16182583
Kar Wai Alvin Lee, Lisa Kwin Wah Chan, Angela Wai Kay Lee, Cheuk Hung Lee, Sky Tin Hau Wong, Kyu-Ho Yi
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引用次数: 0

摘要

聚对苯二甲酸(PDLLA)是一种可生物降解且具有生物相容性的聚合物,因其独特的性能和广泛的应用而在皮肤科领域备受关注。本文献综述全面分析了 PDLLA 在各种皮肤病和伤口愈合应用中的作用。PDLLA 在增强皮肤弹性和紧致度、减少皱纹、促进组织再生和疤痕重塑方面具有显著优势。其可生物降解的特性使其非常适合用于软组织隆胸,包括面部和乳房重建。我们讨论了了解 PDLLA 的物理和化学特性对优化其性能和安全性的至关重要性,重点是纳米和微粒系统如何改善输送和稳定性。文章强调了肉芽肿形成和非炎症性结节等潜在并发症,并指出有效的监测和早期干预策略至关重要。由于 PDLLA 具有卓越的机械稳定性和生物相容性,其应用已从皮肤科扩展到整形外科和给药领域。本综述强调了持续研究的必要性,以充分阐明 PDLLA 的作用机制,最大限度地发挥其在不同医疗领域的治疗潜力。
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Poly-d,l-lactic Acid (PDLLA) Application in Dermatology: A Literature Review
Poly-d,l-lactic acid (PDLLA) is a biodegradable and biocompatible polymer that has garnered significant attention in dermatology due to its unique properties and versatile applications. This literature review offers a comprehensive analysis of PDLLA’s roles in various dermatological conditions and wound-healing applications. PDLLA demonstrates significant benefits in enhancing skin elasticity and firmness, reducing wrinkles, and promoting tissue regeneration and scar remodeling. Its biodegradable properties render it highly suitable for soft tissue augmentation, including facial and breast reconstruction. We discuss the critical importance of understanding PDLLA’s physical and chemical characteristics to optimize its performance and safety, with a focus on how nano- and micro-particulate systems can improve delivery and stability. While potential complications, such as granuloma formation and non-inflammatory nodules, are highlighted, effective monitoring and early intervention strategies are essential. PDLLA’s applications extend beyond dermatology into orthopedics and drug delivery, owing to its superior mechanical stability and biocompatibility. This review underscores the need for ongoing research to fully elucidate the mechanisms of PDLLA and to maximize its therapeutic potential across diverse medical fields.
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来源期刊
Polymers
Polymers POLYMER SCIENCE-
CiteScore
8.00
自引率
16.00%
发文量
4697
审稿时长
1.3 months
期刊介绍: Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.
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