An-Yi Wang, He-Ying Hu, Yan Sun, Ya-Nan Ou, Ya-Hui Ma, Meng Li, Qiong-Yao Li, Lan Tan
{"title":"空气污染与城市老年人脑脊液α-突触核蛋白之间的关系:CABLE 研究","authors":"An-Yi Wang, He-Ying Hu, Yan Sun, Ya-Nan Ou, Ya-Hui Ma, Meng Li, Qiong-Yao Li, Lan Tan","doi":"10.3389/fnagi.2024.1422772","DOIUrl":null,"url":null,"abstract":"IntroductionIncreasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O<jats:sub>3</jats:sub>], nitrogen dioxide [NO<jats:sub>2</jats:sub>], and particulate matter [PM<jats:sub>2.5</jats:sub>]) with CSF α-syn levels in urban older adults.MethodsWe included 933 urban participants from the Chinese Alzheimer’s Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF α-syn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (CHD) were performed. Moreover, restricted cubic spline (RCS) models were applied to explore the potential nonlinear relationships.ResultsWe found a significant correlation of CSF α-syn level with PM<jats:sub>2.5</jats:sub> in urban participants. Specifically, multiple linear regression showed a significant negative association between PM<jats:sub>2.5</jats:sub> and CSF α-syn level (<jats:italic>p</jats:italic> = 0.029), which was more significant in female, midlife, non-CHD, and cold season subgroups. Besides, RCS models showed that O<jats:sub>3</jats:sub> had an inverse J-shaped association with CSF α-syn levels in urban participants (<jats:italic>p</jats:italic> for nonlinearity = 0.040), and the harmful effect possibly appeared when O<jats:sub>3</jats:sub> was above 37.9 ppb.DiscussionLong-term exposure to air pollution was associated with lower CSF α-syn levels, which may offer a new direction for exploring and preventing synucleinopathies.","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study\",\"authors\":\"An-Yi Wang, He-Ying Hu, Yan Sun, Ya-Nan Ou, Ya-Hui Ma, Meng Li, Qiong-Yao Li, Lan Tan\",\"doi\":\"10.3389/fnagi.2024.1422772\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"IntroductionIncreasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O<jats:sub>3</jats:sub>], nitrogen dioxide [NO<jats:sub>2</jats:sub>], and particulate matter [PM<jats:sub>2.5</jats:sub>]) with CSF α-syn levels in urban older adults.MethodsWe included 933 urban participants from the Chinese Alzheimer’s Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF α-syn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (CHD) were performed. Moreover, restricted cubic spline (RCS) models were applied to explore the potential nonlinear relationships.ResultsWe found a significant correlation of CSF α-syn level with PM<jats:sub>2.5</jats:sub> in urban participants. Specifically, multiple linear regression showed a significant negative association between PM<jats:sub>2.5</jats:sub> and CSF α-syn level (<jats:italic>p</jats:italic> = 0.029), which was more significant in female, midlife, non-CHD, and cold season subgroups. Besides, RCS models showed that O<jats:sub>3</jats:sub> had an inverse J-shaped association with CSF α-syn levels in urban participants (<jats:italic>p</jats:italic> for nonlinearity = 0.040), and the harmful effect possibly appeared when O<jats:sub>3</jats:sub> was above 37.9 ppb.DiscussionLong-term exposure to air pollution was associated with lower CSF α-syn levels, which may offer a new direction for exploring and preventing synucleinopathies.\",\"PeriodicalId\":12450,\"journal\":{\"name\":\"Frontiers in Aging Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Aging Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fnagi.2024.1422772\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2024.1422772","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study
IntroductionIncreasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O3], nitrogen dioxide [NO2], and particulate matter [PM2.5]) with CSF α-syn levels in urban older adults.MethodsWe included 933 urban participants from the Chinese Alzheimer’s Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF α-syn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (CHD) were performed. Moreover, restricted cubic spline (RCS) models were applied to explore the potential nonlinear relationships.ResultsWe found a significant correlation of CSF α-syn level with PM2.5 in urban participants. Specifically, multiple linear regression showed a significant negative association between PM2.5 and CSF α-syn level (p = 0.029), which was more significant in female, midlife, non-CHD, and cold season subgroups. Besides, RCS models showed that O3 had an inverse J-shaped association with CSF α-syn levels in urban participants (p for nonlinearity = 0.040), and the harmful effect possibly appeared when O3 was above 37.9 ppb.DiscussionLong-term exposure to air pollution was associated with lower CSF α-syn levels, which may offer a new direction for exploring and preventing synucleinopathies.
期刊介绍:
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.